Angioregulatory role of miRNAs and exosomal miRNAs in glioblastoma pathogenesis

Bouzari, Behnaz; Mohammadi, Shabahang; Bokov, Dmitry Olegovich; Krasnyuk, I. I.; Hosseini‐Fard, Seyed Reza; Hajibaba, Marzieh; Mirzaei, Rasoul; Karampoor, Sajad

doi:10.1016/j.biopha.2022.112760

Cited by 16 publications

(4 citation statements)

References 235 publications

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“…These findings suggest that SEVs carrying DII4 can augment the migratory behavior of endothelial cells while concurrently restraining their proliferative activity [134]. A growing body of evidence suggests the involvement of SEV miR in the regulation of angiogenesis and its subsequent effects on the advancement of tumors [135,136]. For instance, the CD105positive renal cancer stem cells released pro-angiogenic mRNAs and miRs, which enhanced the development of lung metastases [137].…”

Section: Pro-angiogenic Tumor Responsementioning

confidence: 99%

Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance

Zhang,

Qin,

Dewanjee

et al. 2024

Mol Cancer

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The production and release of tumor-derived small extracellular vesicles (TDSEVs) from cancerous cells play a pivotal role in the propagation of cancer, through genetic and biological communication with healthy cells. TDSEVs are known to orchestrate the invasion-metastasis cascade via diverse pathways. Regulation of early metastasis processes, pre-metastatic niche formation, immune system regulation, angiogenesis initiation, extracellular matrix (ECM) remodeling, immune modulation, and epithelial-mesenchymal transition (EMT) are among the pathways regulated by TDSEVs. MicroRNAs (miRs) carried within TDSEVs play a pivotal role as a double-edged sword and can either promote metastasis or inhibit cancer progression. TDSEVs can serve as excellent markers for early detection of tumors, and tumor metastases. From a therapeutic point of view, the risk of cancer metastasis may be reduced by limiting the production of TDSEVs from tumor cells. On the other hand, TDSEVs represent a promising approach for in vivo delivery of therapeutic cargo to tumor cells. The present review article discusses the recent developments and the current views of TDSEVs in the field of cancer research and clinical applications.

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Section: Pro-angiogenic Tumor Responsementioning

confidence: 99%

Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance

Zhang,

Qin,

Dewanjee

et al. 2024

Mol Cancer

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“…Furthermore, HIF2α knockdown diminishes VEGF expression, precludes GSC-induced angiogenesis, and therefore is considered a promising target for anti-GBM therapeutics. The upregulation of miR-218 as a newly discovered tumor suppressor miRNA has proven to be a viable approach to dealing with chemoresistance [62].…”

Section: Mir-218mentioning

confidence: 99%

The Role of microRNAs in Multidrug Resistance of Glioblastoma

Mahinfar

Mansoori

Rostamzadeh

et al. 2022

Cancers

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Glioblastoma (GBM) is an aggressive brain tumor that develops from neuroglial stem cells and represents a highly heterogeneous group of neoplasms. These tumors are predominantly correlated with a dismal prognosis and poor quality of life. In spite of major advances in developing novel and effective therapeutic strategies for patients with glioblastoma, multidrug resistance (MDR) is considered to be the major reason for treatment failure. Several mechanisms contribute to MDR in GBM, including upregulation of MDR transporters, alterations in the metabolism of drugs, dysregulation of apoptosis, defects in DNA repair, cancer stem cells, and epithelial–mesenchymal transition. MicroRNAs (miRNAs) are a large class of endogenous RNAs that participate in various cell events, including the mechanisms causing MDR in glioblastoma. In this review, we discuss the role of miRNAs in the regulation of the underlying mechanisms in MDR glioblastoma which will open up new avenues of inquiry for the treatment of glioblastoma.

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“…miRNA-mediated gene expression modulation can occur via mRNA breakdown or translational suppression. miRNAs attach to the target mRNA’s 3-untranslated region (3-UTR) via incorrect base-pairing and can control a wide range of genetic components simultaneously ( 82 – 84 ). As a result, miRNAs, such as transcriptional regulators, could function as master gene modulators and collaborate to establish gene expression profiles in cells ( 85 ).…”

Section: Mirnas and Metabolic Reprogramming Of Cancer Cellsmentioning

confidence: 99%

Metabolic reprogramming by miRNAs in the tumor microenvironment: Focused on immunometabolism

et al. 2022

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MicroRNAs (miRNAs) are emerging as a significant modulator of immunity, and their abnormal expression/activity has been linked to numerous human disorders, such as cancer. It is now known that miRNAs potentially modulate the production of several metabolic processes in tumor-associated immune cells and indirectly via different metabolic enzymes that affect tumor-associated signaling cascades. For instance, Let-7 has been identified as a crucial modulator for the long-lasting survival of CD8+ T cells (naive phenotypes) in cancer by altering their metabolism. Furthermore, in T cells, it has been found that enhancer of zeste homolog 2 (EZH2) expression is controlled via glycolytic metabolism through miRNAs in patients with ovarian cancer. On the other hand, immunometabolism has shown us that cellular metabolic reactions and processes not only generate ATP and biosynthetic intermediates but also modulate the immune system and inflammatory processes. Based on recent studies, new and encouraging approaches to cancer involving the modification of miRNAs in immune cell metabolism are currently being investigated, providing insight into promising targets for therapeutic strategies based on the pivotal role of immunometabolism in cancer. Throughout this overview, we explore and describe the significance of miRNAs in cancer and immune cell metabolism.

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Angioregulatory role of miRNAs and exosomal miRNAs in glioblastoma pathogenesis

Cited by 16 publications

References 235 publications

Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance

Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance

The Role of microRNAs in Multidrug Resistance of Glioblastoma

Metabolic reprogramming by miRNAs in the tumor microenvironment: Focused on immunometabolism

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