2010
DOI: 10.1074/jbc.m109.097543
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Angiopoietin-2 Stimulation of Endothelial Cells Induces αvβ3 Integrin Internalization and Degradation

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Cited by 88 publications
(85 citation statements)
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References 44 publications
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“…Confirming previous studies on the non-cytotoxicity of the ANG-2 antibody (26), treatment did not impair cell survival (Supplemental Figure 6F), necrosis (Supplemental Figure 6H), or apoptosis (Supplemental Figure 6G). These findings suggest that the protective effect of ANG-2 on ECs is mediated in an intracellular autocrine manner, as has previously been inferred from cellular experiments (13,14).…”
Section: Ang-2 Induces Ec Migration In Tie2 Losupporting
confidence: 82%
See 1 more Smart Citation
“…Confirming previous studies on the non-cytotoxicity of the ANG-2 antibody (26), treatment did not impair cell survival (Supplemental Figure 6F), necrosis (Supplemental Figure 6H), or apoptosis (Supplemental Figure 6G). These findings suggest that the protective effect of ANG-2 on ECs is mediated in an intracellular autocrine manner, as has previously been inferred from cellular experiments (13,14).…”
Section: Ang-2 Induces Ec Migration In Tie2 Losupporting
confidence: 82%
“…In contrast to the destabilizing roles of ANG-2 on resting ECs (13,14), ANG-2 has been shown to act as an antiapoptotic protective factor for stressed ECs (15), which themselves are particularly strong producers of ANG-2 (16,17). Several groups have recently reported that the ANG-2-positive tumor endothelium harbors a subpopulation of ECs that do not express its receptor TIE2 (18)(19)(20)(21)(22).…”
Section: Introductionmentioning
confidence: 99%
“…Recent reports have shown that the integrin degradation pathway is also essential for the control of cell behavior [5,44]. Association between cells and the extracellular matrix is effectively regulated by the integrin degradation pathway [7]. The key finding in this study is that exosomes act as an inducer of the integrin degradation pathway.…”
Section: Discussionmentioning
confidence: 63%
“…Ubiquitination of integrin acts as a signal to trigger trafficking of internalized integrin to the lysosomal degradation compartment [5,6]. The degradation process is important for controlling the proper expression level of integrin on the cell surface, by which cell-matrix association and cell migration are tightly regulated [5,7].Integrin is a key regulator of cellular functions associated with vascular processes [8,9]. Endothelial cell migration and leukocyte recruitment during inflammation are tightly controlled by integrin functions.…”
mentioning
confidence: 99%
“…Furthermore, overexpression of Ang2 in MCF-7 promoted their metastasis to lymph nodes and lungs, an effect postulated to result from direct interaction between Ang2 and beta1 integrins on tumor cells (much the way Ang2 was reported to facilitate sprouting of Tie2-negative tip cells; refs. 11,27). The delineation of autocrine versus paracrine presentation of Ang2 still needs to be carefully investigated.…”
Section: Outstanding Questions and Future Directions For Rational Intmentioning
confidence: 99%