2001
DOI: 10.1016/s0735-1097(00)01040-8
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Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA

Abstract: These results indicate that PTCA induces coronary sinus increase in F2-isoprostane formation, and they also provide direct evidence for enhanced oxidative stress in a local milieu in vivo. Thus, an increased F2-isoprostane formation could play a role in the pathogenesis of some PTCA-associated untoward events.

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Cited by 104 publications
(81 citation statements)
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“…The cellular mechanisms for this finding have not yet been identified, but the larger lumen dimensions after PCI raise the possibility that countering oxidative stress may rapidly improve endothelial function and reduce vasomotor tone, 14,15 thereby allowing for optimal response to balloon dilatation and stenting. Balloon injury indeed leads to the immediate release of reactive oxygen species, 16,17 which may be inhibited by powerful antioxidants. Alternatively, changes in plaque content caused by these agents may have favored axial redistribution of plaque away from the dilated site toward the noninjured regions during PCI.…”
Section: Discussionmentioning
confidence: 99%
“…The cellular mechanisms for this finding have not yet been identified, but the larger lumen dimensions after PCI raise the possibility that countering oxidative stress may rapidly improve endothelial function and reduce vasomotor tone, 14,15 thereby allowing for optimal response to balloon dilatation and stenting. Balloon injury indeed leads to the immediate release of reactive oxygen species, 16,17 which may be inhibited by powerful antioxidants. Alternatively, changes in plaque content caused by these agents may have favored axial redistribution of plaque away from the dilated site toward the noninjured regions during PCI.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, enhanced oxidative stress plays a critical role in the deleterious effect of aging on the endothelium through acceleration of NO breakdown by reactive oxygen species (8)(9)(10)(11)(12)(13)(14). Increased oxidative stress also occurs during vascular response to PTCA (54,55). Thus, increased lipid peroxidation and oxidative stress with aging (56) together with vascular changes related to NO bioavailability may contribute to the higher severity of restenosis in elderly patients.…”
Section: Discussionmentioning
confidence: 99%
“…5 During PCI, atheromatous plaque may be dislodged, leading to embolization of debris, thrombus, microparticles, and active peptides. 5,21 Existing microcirculatory impairment may predispose toward plugging or attenuated clearing of embolized material and, therefore, increase susceptibility toward developing periprocedural MI. The present study of a cohort of patients without main or branch vessel closure supports this hypothesis.…”
Section: Association Between Microcirculatory Status and Periprocedurmentioning
confidence: 99%