Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA

Iuliano, Luigi; Praticò, Domenico; Greco, Cesare; Madon, E; Scibilia, G; FitzGerald, Garret A.; Violi, Francesco

doi:10.1016/s0735-1097(00)01040-8

Cited by 104 publications

(81 citation statements)

References 33 publications

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“…The cellular mechanisms for this finding have not yet been identified, but the larger lumen dimensions after PCI raise the possibility that countering oxidative stress may rapidly improve endothelial function and reduce vasomotor tone, 14,15 thereby allowing for optimal response to balloon dilatation and stenting. Balloon injury indeed leads to the immediate release of reactive oxygen species, 16,17 which may be inhibited by powerful antioxidants. Alternatively, changes in plaque content caused by these agents may have favored axial redistribution of plaque away from the dilated site toward the noninjured regions during PCI.…”

Section: Discussionmentioning

confidence: 99%

Effects of AGI-1067 and Probucol After Percutaneous Coronary Interventions

et al. 2003

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Background— AGI-1067, a metabolically stable modification of probucol, is an equipotent antioxidant to probucol but is pharmacologically distinct. In a multicenter trial, we studied whether AGI-1067 reduces restenosis assessed by intravascular ultrasound (IVUS) after percutaneous coronary intervention (PCI) compared with placebo and probucol used as a positive control. Methods and Results— Two weeks before PCI, 305 patients were randomly assigned to 1 of 5 treatment groups: placebo, probucol 500 mg BID, or AGI-1067 70, 140, or 280 mg once daily. Patients were treated for 2 weeks before and 4 weeks after PCI. Baseline and 6-month follow-up IVUS were interpreted by a blinded core laboratory. Stents were used in 85% of patients. Luminal area at the PCI site at follow-up was 2.66±1.58 mm 2 for placebo, 3.69±2.69 mm 2 for probucol, 2.75±1.76 mm 2 for AGI-1067 70 mg, 3.17±2.26 mm 2 for AGI-1067 140 mg, and 3.36±2.12 mm 2 for AGI-1067 280 mg ( P =0.02 for the dose-response relationship; P ≤0.05 for AGI-1067 280 mg and probucol versus placebo). There was a mean narrowing of 5.3 mm 3 of reference segment lumen in the placebo group and an enlargement in the AGI-1067 140- and 280-mg groups at follow-up ( P =0.05 for 140 mg). An increase in QTc interval >60 ms occurred in 4.8% of placebo patients, 17.4% of probucol patients, and 4.8%, 2.4%, and 2.5% of patients in the AGI-1067 groups ( P =0.02). Conclusions— AGI-1067 and probucol reduce restenosis after PCI. In contrast to probucol, AGI-1067 did not cause prolongation of the QTc interval and improved lumen dimensions of reference segments, suggestive of a direct effect on atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Effects of AGI-1067 and Probucol After Percutaneous Coronary Interventions

et al. 2003

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“…Furthermore, enhanced oxidative stress plays a critical role in the deleterious effect of aging on the endothelium through acceleration of NO breakdown by reactive oxygen species (8)(9)(10)(11)(12)(13)(14). Increased oxidative stress also occurs during vascular response to PTCA (54,55). Thus, increased lipid peroxidation and oxidative stress with aging (56) together with vascular changes related to NO bioavailability may contribute to the higher severity of restenosis in elderly patients.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis

Napoli

Aldini

Wallace

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

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Restenosis after percutaneous transluminal coronary angioplasty is caused by neointimal hyperplasia, which involves impairment of nitric oxide (NO)-dependent pathways, and may be further exacerbated by a concomitant aging process. We compared the effects of NO-releasing-aspirin (NCX-4016) and aspirin (ASA) on experimental restenosis in both adult and elderly rats. Moreover, to ascertain the efficacy of NCX-4016 during vascular aging, we fully characterized the release of bioactive NO by the drug. SpragueDawley rats aged 6 and 24 months were treated with NO releasingaspirin (55 mg͞kg) or ASA (30 mg͞kg) for 7 days before and 21 days after standard carotid balloon injury. Histological examination and immunohistochemical double-staining were used to evaluate restenosis. Plasma nitrite and nitrate and S-nitrosothiols were determined by a chemiluminescence-based assay. Electron spin resonance was used for determining nitrosylhemoglobin. Treatment of aged rats with NCX-4016 was associated with increased bioactive NO, compared with ASA. NO aspirin, but not ASA, reduced experimental restenosis in old rats, an effect associated with reduced vascular smooth muscle cell proliferation. NCX-4016, but not ASA, was well tolerated and virtually devoid of gastric damage in either adult or old rats. Thus, impairment of NO-dependent mechanisms may be involved in the development of restenosis in old rats. We suggest that an NCX-4016 derivative could be an effective drug in reducing restenosis, especially in the presence of aging and͞or gastrointestinal damage.

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“…5 During PCI, atheromatous plaque may be dislodged, leading to embolization of debris, thrombus, microparticles, and active peptides. 5,21 Existing microcirculatory impairment may predispose toward plugging or attenuated clearing of embolized material and, therefore, increase susceptibility toward developing periprocedural MI. The present study of a cohort of patients without main or branch vessel closure supports this hypothesis.…”

Section: Association Between Microcirculatory Status and Periprocedurmentioning

confidence: 99%

The Index of Microcirculatory Resistance Predicts Myocardial Infarction Related to Percutaneous Coronary Intervention

Yong

et al. 2012

Circ: Cardiovascular Interventions

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Background-Periprocedural myocardial infarction (MI) occurs in a significant proportion of patients undergoing percutaneous coronary intervention (PCI) and portends poor outcomes. Currently, no clinically applicable method predicts periprocedural MI in the cardiac catheterization laboratory before it occurs. We hypothesized that impaired baseline coronary microcirculatory reserve, which reduces the ability to tolerate ischemic insults, is a risk for periprocedural MI and that the index of microcirculatory resistance (IMR) measured during PCI can predict occurrence of periprocedural MI. Methods and Results-Consecutive patients undergoing elective PCI of a single lesion in the left anterior descending coronary artery were recruited. A pressure-temperature sensor wire was used to measure IMR before PCI. Of the 50 patients studied, 10 had periprocedural MI. From binary logistic regression analyses of all clinical, procedural, and physiological parameters, univariable predictors of periprocedural MI were pre-PCI IMR (P=0.003) and the number of stents used (P=0.039). Pre-PCI IMR was the only independent predictor in bivariable regression analyses performed by adjusting for each available covariate one at a time (all P≤0.02). Pre-PCI IMR ≥27 U had 80.0% sensitivity and 85.0% specificity for predicting periprocedural MI (C statistic, 0.80; P=0.003). Pre-PCI IMR ≥27 U was independently associated with a 23-fold risk of developing periprocedural MI (odds ratio, 22.7; 95% CI, 3.8-133.9). Conclusions-These data suggest that the status of the coronary microcirculation plays a role in determining susceptibility toward periprocedural MI at the time of elective PCI. The IMR can predict subsequent risk of developing myocardial necrosis and may guide adjunctive prevention strategies. (Circ Cardiovasc Interv. 2012;5:515-522.)

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Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA

Cited by 104 publications

References 33 publications

Effects of AGI-1067 and Probucol After Percutaneous Coronary Interventions

Effects of AGI-1067 and Probucol After Percutaneous Coronary Interventions

Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis

The Index of Microcirculatory Resistance Predicts Myocardial Infarction Related to Percutaneous Coronary Intervention

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