Angiomyolipoma of the Kidney with Lymph Node Involvement

Ansari, Shoaib; Stephenson, Robert A.; Mackay, Bruce

doi:10.3109/01913129109016260

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…This puzzling lesion, probably hamartomatous in nature, arises most commonly in one or both kidneys as a solitary or multicentric mass. Extrarenal sites of AML include the liver (2, 3), spleen (4), lymph node (5,6), spermatic cord (7), penis (8), vagina (9), uterus (10), fallopian tube (11), oral cavity (12), nasal cavity (13), lung (14), heart (15), colon (16), abdominal wall (17), retroperitoneum (18), mediastinum (19,20), epidurally in the spine (21,22), subgalea aponeurotica (23), and skin (1,(24)(25)(26). To the best of our knowledge only 11 cases of cutaneous AML have been described.…”

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confidence: 99%

Cutaneous angiomyolipoma

Val-Bernal

Mira

1996

J Cutan Pathol

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Extrarenal angiomyolipomas are rare lesions. An angiomyolipoma located on the right ear lobe in a 49-year-old man is reported. Pathologic examination showed a well-circumscribed subcutaneous nodule, 2 cm in diameter. The components of the tumor were confirmed by immunohistochemistry. Reactivity for HMB-45 was negative. A review of the twelve published cases, including the present, reveals that the patients age ranged from 33 to 77 years (mean 53.6), the male/female ratio was 11.1. The tumors were solitary, asymptomatic, noninvasive, located most commonly in acral skin or on the ear. The clinical impression is that of a cyst, a lipoma or a vascular tumor. Signs of tuberous sclerosis were absent in all cases. In contrast to the renal form, the cutaneous angiomyolipoma is a tumor differing in sex predominance, clinical associations, circumscription, solitariness, and HMB-45 immunoreactivity. Distinction from other mesenchymal lesions depends on recognition of traditional histologic criteria.

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confidence: 99%

Cutaneous angiomyolipoma

Val-Bernal

Mira

1996

J Cutan Pathol

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“…Furthermore, inadequate sampling of the tumour may cause the presence of adipose tissue being missed. Ansari et al [1] described areas reminiscent of LAM in regional lymph nodes of a 46-year-old woman with renal AML extending into the lymph nodes, and McIntosh et al [10] reported a case of multiple renal AML occurring with LAM of the regional lymph nodes in a 55-year-old woman. The presence of LAM-like foci in renal AML was also documented by Chan et al [3].…”

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confidence: 97%

An unusual renal angiomyolipoma with morphological lymphangioleiomyomatosis features and coexpression of oestrogen and progesterone receptors

2001

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Angiomyolipoma is the most common mesenchymal renal tumour, the clonal origin of which has recently been demonstrated. It is composed of varying amounts of blood vessels, smooth muscle and fat. In this report, we describe a renal angiomyolipoma, which is unusual owing to the presence of a lymphangioleiomyomatosis-like component, occurring in a 41-year-old woman suffering from sporadic lymphangioleiomyomatosis. The diagnosis was based on histopathological and immunohistochemical findings. The tumour consisted of an intimate admixture of two components: one was typical of a classical angiomyolipoma and the other was reminiscent of lymphangioleiomyomatosis. HMB45 positivity was found on 5% of the cells of the angiomyolipoma component. Ten percent of the nuclei of the lymphangioleiomyomatosis and angiomyolipoma components expressed oestrogen receptors and 5% progesterone receptors. This case illustrates a very unusual pattern of a renal angiomyolipoma containing a lymphangioleiomyomatosis-like component. The oestrogen and progesterone immunoreactivity suggests that angiomyolipoma could be hormonally dependent. Therefore, we have emphasised the morphological and immunohistochemical similarities between angiomyolipoma and lymphangioleiomyomatosis.

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“…We searched English-language articles in the Medline database using the key words “kidney” or “renal,” “angiomyolipoma” or “hamartoma” and “lymph node.” Twenty-two papers were found. Based on the full text of the articles rather than only the abstracts, 16 papers and 25 cases were found to be relevant 4–19 (Table 1). Busch et al.…”

Section: Discussionmentioning

confidence: 99%

“…Twentytwo papers were found. Based on the full text of the articles rather than only the abstracts, 16 papers and 25 cases were found to be relevant [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] (Table 1). Busch et al 4 reported the first two cases of benign renal AML with regional lymph node involvement in 1976.…”

Section: Discussionmentioning

confidence: 99%

Sporadic multiple renal angiomyolipoma with lymph node involvement: a case report and literature review

et al. 2021

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Angiomyolipoma (AML) is a benign tumor that mainly occurs in the kidneys. Simultaneous involvement of the kidney and local regional lymph nodes is very rare and might be misdiagnosed as a metastasizing malignant cancer. In the present study, a 50-year-old woman was referred to our hospital after a routine health screening ultrasound. Sporadic multiple renal AML with lymph node involvement was suspected based on the clinical manifestations and radiologic features. Partial nephrectomy was performed and a para-inferior vena cava lymph node was removed. The pathologic results confirmed multiple AML with lymph node invasion. We also reviewed the English-language literature regarding renal AML with lymph node involvement. We found that middle-aged women were likely to develop this disease and that loin pain was the main presenting feature. Most patients had no history of tuberous sclerosis complex. Radical nephrectomy was the predominant treatment. No local recurrence or distant metastasis occurred in any patients after radical nephrectomy or partial nephrectomy. In conclusion, renal AML with lymph node involvement is rare but can occur in both patients with tuberous sclerosis complex and those with multiple sporadic AML. Partial nephrectomy should be the first-line treatment, after which further treatment is not necessary.

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Angiomyolipoma of the Kidney with Lymph Node Involvement

Cited by 10 publications

References 16 publications

Cutaneous angiomyolipoma

Cutaneous angiomyolipoma

An unusual renal angiomyolipoma with morphological lymphangioleiomyomatosis features and coexpression of oestrogen and progesterone receptors

Sporadic multiple renal angiomyolipoma with lymph node involvement: a case report and literature review

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