Angiomyofibroblastoma of the Vulva: Report of a Case

Tochika, Naoshige; Takeshita, Atsunori; Shinmoto, Hiroshi; Matsumoto, Manabu; Kobayashi, Mariko; Araki, Keijiro

doi:10.1007/s005950170123

Cited by 20 publications

(10 citation statements)

References 7 publications

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“…Clinically this tumor is known to be confused with Bartholin cyst, leiomyoma or other benign tumours. 20 It was grossly well circumcised, pink to red in color, firm in consistency and microscopy showed hypo and hypercellular areas of vascular, edematous stroma. Clustering of spindle tumor cells around blood vessels is peculiar of this tumor which helps to differentiate this from aggressive angiomyxoma, its differential diagnosis on histology [ Figure 4(C)].…”

Section: Discussionmentioning

confidence: 98%

Spectrum of vulvar lesions: patient’s anxiety, clinician’s concern and pathologist’s diagnostic challenge

Bhat

Mahajan

Kumbhalkar

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: A wide variety of inflammatory, premalignant and malignant lesions can occur on the vulva. Some of the lesions are limited to the vulva, while some also involve other parts of the body. Although vulvar diseases can cause a significant issue in the patients, they are less commonly discussed than those of cervix, uterus and ovary. Most of the asymptomatic lesions remain un-noticed, and are seen during routine gynecological checkups. Common complaints in symptomatic lesions are lumps, discomfort, itching and pain. Since the symptoms are nonspecific; determining the location of the lesion can assist with the diagnosis. Being a genital part with skin covering on outer aspect and mucosal lining inside, it is associated with various dermatological, nutritional, and hormonal as well as sexually transmitted diseases. The present study thus was conducted to categorize vulvar lesions based on their histological diagnosis and also to study the morphological spectrum of precursor lesions for malignancy. Methods: Present study includes all types of vulvar lesions sent for pathological study in the Department of pathology, at GMC Nagpur over the period of one year. Results: Total 34 lesions were studied including a wide diagnostic range from inflammatory, dermatological to benign, premalignant and malignant. Inflammatory lesions including various infections and LSA (Lichen sclerosus atrophicus) were the most commonly seen lesions along with collection of neoplastic lesions. Conclusions: Proper diagnostic categorization of the lesions is essential for initiating therapy and reducing patient's anxiety. Morphology of these lesions along with their diagnostic significance is discussed.

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Section: Discussionmentioning

confidence: 98%

Spectrum of vulvar lesions: patient’s anxiety, clinician’s concern and pathologist’s diagnostic challenge

Bhat

Mahajan

Kumbhalkar

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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“…It is typically a well-demarcated tumor that ranges in size from 0.5 to 12 cm (mean 4.5 cm). The size of the AMF in our patient, 23 cm, exceeds that of any AMF reported to date, although fewer than 150 cases have been reported [5], including those in the Japanese literature [6]. Overall, AMF is a benign non-recurring tumor, but there has been only one report of AMF with sarcomatous transformation that recurred [7].…”

Section: Discussionmentioning

confidence: 49%

Huge pedunculated angiomyofibroblastoma of the vulva

Nagai¹,

Aadachi²,

Saito³

2010

Int J Clin Oncol

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We present the case of a huge pedunculated benign mesenchymal myxoid tumor that developed on the right labia majora of a 48-year-old-woman. The excised mass weighed 4534 g and was 23 cm in diameter; the cut surface was yellowish and elastic. Microscopic examination revealed spindle and plump oval tumor cells arranged with abundant capillary vessels in an edematous stroma. Immunohistochemical staining showed that the tumor cells were positive for vimentin, desmin, estrogen receptor, and progesterone receptor, but negative for alpha-smooth muscle actin, CD34, CD45, CD68, and S-100. Based on these features, the pathological diagnosis was angiomyofibroblastoma. A pedunculated angiomyofibroblastoma is extremely rare and, to the best of our knowledge, this is the biggest such tumor in terms of size and weight reported to date. It is especially important in such a huge mass greater than 10 cm that angiomyofibroblastoma is differentiated from aggressive angiomyxoma, which is a deeply invasive and recurrent neoplasm.

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“…They usually complain of a painless mass that has been present from a few weeks to up to 13 years [5]. Clinically, these tumors are frequently thought to be a Bartholin gland cyst, although a preoperative differential diagnosis includes labial cysts, inguinal hernia, leiomyoma, and mesenchymal tumors such as lipoma and liposarcoma [15]. …”

Section: Discussionmentioning

confidence: 99%

Pedunculated Angiomyofibroblastoma of the Vulva: Case Report and Review of the Literature

Giannella¹,

Costantini

Mfuta³

et al. 2011

Case Reports in Medicine

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Angiomyofibroblastoma (AMFB) is a rare benign mesenchymal tumour that occurs almost exclusively in the vulvovaginal region of women but can also occur occasionally in the inguinoscrotal region of men. It is a well-circumscribed lesion that clinically is often thought to represent a Bartholin's gland cyst and usually does not form a pedunculated mass. To our knowledge, only five cases of vulvar AMFB with pedunculated mass have been reported in the English literature and all cases involving the labia majora and middle-aged women. We report the first case of pedunculated AMFB of the vulva occurring in a young woman of 21 years old and involving the left labia minora. After excluding the most common diseases, pedunculated AMFB should be part of differential diagnosis in the workup of any pedunculated vulvar mass even in young women with a lesion involving the labia minora. We reviewed the literature and summarized all reported cases.

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Angiomyofibroblastoma of the Vulva: Report of a Case

Cited by 20 publications

References 7 publications

Spectrum of vulvar lesions: patient’s anxiety, clinician’s concern and pathologist’s diagnostic challenge

Spectrum of vulvar lesions: patient’s anxiety, clinician’s concern and pathologist’s diagnostic challenge

Huge pedunculated angiomyofibroblastoma of the vulva

Pedunculated Angiomyofibroblastoma of the Vulva: Case Report and Review of the Literature

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