Angiomyofibroblastoma of the uterine cervix in a patient with triple negative breast cancer: a case report

Abstract

Angiomyofibroblastoma is an uncommon, benign mesenchymal tumor which generally occurs in the vulvovaginal region. Uterine cervix localisation is uncommon. A 40-year-old female patient, who had been operated becasue of breast carcinoma, presented vaginal bleeding. Examination revealed a polypoid mass located in both vagina and cervix. She underwent total abdominal hysterectomy and bilateral salpingectomy. With the help of typical histopathology and immunohistochemical findings, a diagnosis of "angiomyofibroblastoma" was made. Angiomyofibroblastoma is a benign mesenchymal tumor of unknown pathogenesis. A recognition of this entity is important to avoid misdagnosis of other angiomyxoid neoplasms such as aggressive angiomyxoma.

Recurrent vulval angiomyofibroblastoma; An unusual benign mesenchymal tumour, misdiagnosed

“…This was a case series of 10 patients with angiomyofibroblastoma [6]. The average age of females with angiomyofibroblastoma is between 30 to 50 years [1,3]. The age of our patient was 57 years.…”

“…The size of the tumour is variable ranging from less than 5 cm for vulvar angiomyofibroblastoma to more than 6 cm for cervical tumours and up to 37 cm in some studies [1,3,4]. Macroscopically the tumour has been described as a myxoid homogenous mass with well-circumscribed borders and margins in the majority of studies and histologically by areas of hypercellularity and hypocellularity with internal vascularity.…”

“…Both of them are difficult to diagnose and differentiate due to the rarity and overlapping gross morphological characteristics, histopathology, and immunohistochemistry features [1,2]. Angiomyofibroblastoma is the benign variant characterized by myofibroblastic cells and stromal cell differentiation and proliferation [3]. The tumor can occur in both males and females.…”

“…Although, the tumour is rare in males the predominance site is the inguinoscrotal region, while the perineal region and vulva are common sites in females. The least common site in females is the uterine cervix being reported in 5 case reports to date, fallopian tube, and rarely urethra [3,4].…”