Angiomyelolipoma of the liver

Peters, Wachen; Dixon, M. F.; Williams, Norman S.

doi:10.1111/j.1365-2559.1983.tb02219.x

Cited by 26 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1523. 25 Although the pathogenesis and exact origin of hepatic lipomas in human beings are uncertain,'j these lipomatous neoplasms may be explained by the differentiation of progenitor mesenchymal cells into lipocytes. 26 Other hypotheses have proposed that lipocytes may differentiate from fibroblasts,' pericytes located around ~a p i l l a r i e s ,~~ or a perisinusoidal stem cell, which possibly gives rise to the fat-storing Ito Many of the lesions in our study contained plates of hepatocytes among the signet-ring-shaped and spindleshaped cells.…”

Section: Discussionmentioning

confidence: 99%

“Lipomatous” Lesions of Unknown Cellular Origin in the Liver of B6C3F1 Mice

et al. 1994

View full text Add to dashboard Cite

Abstract. The gross, microscopic, and ultrastructural features of lipomatous lesions in the liver of B6C3F1 mice are described. The cases were selected from a database of 45,406 male and 45,674 female mice used as treated, control, or vehicle-control animals in the National Cancer Institute's Bioassays or the National Toxicology Program's 2-year carcinogenicity studies. Thirteen hepatic lesions identified from cases within the database were re-evaluated microscopically and selected for further study. These lesions were present in ten males and three females that were between 85 and 113 weeks of age at the time of death. Grossly, the liver lesions were described as white to yellow or red to brown nodules/masses or foci that ranged from 2.0 to 25 mm in diameter. The lesions commonly involved the median and left lateral hepatic lobes. Microscopically, many of the lesions closely resembled lipomas described in the liver of human beings, and they consisted of nonencapsulated mature adipose-like tissue with irregular margins. The majority of the cells that comprised the lipomatous lesions were signet-ring shaped. These cells were positive for lipid as evidenced with oil red-0. The lipid droplets were also present within the hepatocytes that comprised the hepatic plates trapped within or surrounding many of the lipomatous lesions. At the margins of many of the lesions there were spindle-shaped cells that contained small intracytoplasmic lipid vacuoles. These cells were often within a stromal matrix that had focal areas of collagen and mucopolysaccharides, as evidenced by weak staining with Masson's tnchrome and periodic acidSchiff s stains, respectively. There was also disruption of the reticulum fibers in many of the lesions, as noted with a Gomori's reticulum stain. Ultrastructurally, cytoplasmic organelles, such as rough endoplasmic reticulum, free ribosomes and small lipid vacuoles, were present in the spindle-shaped cells, whereas signet-ring-shaped cells had few discernible organelles due to peripheral compression of the cytoplasm by single large vacuoles occupying the cytoplasmic space. The spindle-shaped cells were free of lysosomes. Thin collagen fibers were seen in contact with some of the spindle-shaped cells and were located between these cells and adjacent hepatocytes, or endothelial cells lining sinusoidal capillaries. A distinct basal lamina was not associated with spindle-or signet-ring-shaped cells. Similar lipomatous lesions were not found in other visceral organs. The exact cellular origin of the hepatic lesions described here is not known.

show abstract

Section: Discussionmentioning

confidence: 99%

“Lipomatous” Lesions of Unknown Cellular Origin in the Liver of B6C3F1 Mice

et al. 1994

View full text Add to dashboard Cite

show abstract

“…No dimensions for the rat lesions are given (25), but one shown is nodular and bulging on the liver surface, with a diameter probably exceeding 1 cm. Lipomatous tumors/myolipomas in the liver of various species may also be Ito-cell tumors, as in a domestic cat (31), cheetahs and a Siberian tiger (46), a bowhead whale (37), and man (18,41,57,62). Thus, there is some evidence that Ito-cell tumors exist, that they are very rare, in mice and rats reach diameters above 1 cm, compress surrounding liver tissue, and bulge above the surface.…”

Section: Ito-cell Tumors In Mammalsmentioning

confidence: 99%

Review Article: Cystic Degeneration/Spongiosis Hepatis in Rats

Karbe¹,

Kerlin

2002

Toxicol Pathol

View full text Add to dashboard Cite

Cystic degeneration /spongiosis hepatis in rats has been proposed to be a preneoplastic and/or neoplastic lesion by some authors, because of its proliferative properties and persistent increased cell turnover rate in stop experiments using hepatocarcinogens , and the assumption that it can develop into a sarcoma. The neoplastic potential of cystic degeneration is questioned in this review article. Cystic degeneration , which appears to derive from altered Ito cells, does not have neoplastic histomorphologi c characteristics, although it may be composed of cells with an increased mitotic index. In this regard, persistent proliferation is also seen with other nonneoplasti c lesions. Argument s are presented to show that the induced, probably extremely rare sarcoma that was associated with cystic degeneration most likely derives from the very rare induced spherical Ito-cell aggregate with an unusually high cellular turnover rate in rats treated with hepatocarcinogens , and not from cystic degeneration . Also, in none of 12 referenced standard oncogenicity studies with chemically induced cystic degeneration was the lesion associated with mesenchymal (Ito-cell) tumors. Consequently, evidence is lacking that cystic degeneratio n in rats should be classi ed as a preneoplastic or neoplastic lesion.The 12 oncogenicity studies in rats with induced cystic degeneratio n showed a marked sex predilection, with males more likely to develop either spontaneous or chemically induced lesions. In these 12 studies, cystic degeneration was more often associated with hepatocellular hypertrophy or hepatotoxicit y, rather than hepatocarcinogenicit y. Thus, it is concluded that hepatocarcinogen s induce cystic degeneration , not because they are carcinogenic , but because they have other effects on the liver, and that cystic degeneration may be a secondary /reparative change. Cystic degeneration in sh parallels the situation in rats in many respects, yet the existence of the lesion in other species, including man, is not as well supported. Based on the data presented in this review, spontaneous and induced cystic degeneratio n in rats and sh is not a preneoplasti c or neoplastic lesion and risk assessment for man can be based on no-effect levels and safety margins, as for other nonneoplasti c adverse effects that have no counterpart in man.

show abstract

“…In 20 of these the cross-sectional imaging findings were reported [2, 4-8, 11, 13, 16-18, 25-28], whereas the other 29 were published in surgical or pathologic papers [9,10,12,14,15,[19][20][21][22][23][24][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous rupture of a hepatic angiomyolipoma: CT findings and literature review

1997

View full text Add to dashboard Cite

Angiomyolipoma is an uncommon lipomatous neoplasm of the liver, usually asymptomatic and identified incidentally. We describe the CT findings of a surgically confirmed case of spontaneously ruptured angiomyolipoma with evidence of internal hemorrhage and hemoperitoneum. The CT features were that of an exophitic, oval, well-defined mass with inhomogeneous attenuation values due to the presence of fat- and soft-tissue densities. A review of the literature identified 49 cases of hepatic angiomyolipoma. Few of these occurred in symptomatic patients and showed intratumoral hemorrhagic foci, but none had a clear rupture with external bleeding. To our knowledge, this is the first reported case with this complication.

show abstract

Angiomyelolipoma of the liver

Abstract: A case of angiomyelolipoma of the liver occurring in a 54-year-old woman is described. The literature concerning lipomatous liver tumours is reviewed, and the possible histogenetic origin of this neoplasm is discussed.

Cited by 26 publications

References 5 publications

“Lipomatous” Lesions of Unknown Cellular Origin in the Liver of B6C3F1 Mice

“Lipomatous” Lesions of Unknown Cellular Origin in the Liver of B6C3F1 Mice

Review Article: Cystic Degeneration/Spongiosis Hepatis in Rats

Spontaneous rupture of a hepatic angiomyolipoma: CT findings and literature review

Contact Info

Product

Resources

About