Angiomatoid Spitz Nevus

Kwon, Oh Eon; Ku, Bon Seok; Lee, Yeong Kyu; Kim, Young Hun; Kim, Ki Ho

doi:10.5021/ad.2008.20.1.14

Cited by 3 publications

(6 citation statements)

References 6 publications

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“…The melanocytes in ASN usually proliferate solitarily rather than by forming nests in the dermis, whereas nest formation was predominant in our case . This finding seen in our case is rare, with only a few cases with a similar finding having been reported …”

Section: Discussionsupporting

confidence: 63%

“…2 This finding seen in our case is rare, with only a few cases with a similar finding having been reported. 3 Most of the previously reported cases of ASN showed pure dermal lesions or had limited junctional components present only in the epidermis overlying the nodule. 2 In contrast, our case showed epidermal proliferation of single melanocytes surrounding the nodule, which clinically presented with a brown macule.…”

Section: Discussionmentioning

confidence: 96%

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Angiomatoid Spitz nevus with surrounding pagetoid melanocytic proliferation on the sole of the foot: An unusual case report with immunohistochemical studies for angiogenic factors

Anju

Nakamura

Okiyama

et al. 2020

The Journal of Dermatology

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Angiomatoid Spitz nevus (ASN) is a rare histological variant of Spitz nevus (SN) that is characterized by prominent blood vessel proliferation around the intradermal melanocytes of SN. In contrast, SN may have pagetoid components, which are characterized by epidermal proliferation of single melanocytes. However, cases of ASN with predominant pagetoid melanocytic proliferation in the epidermis have not been reported. Here, we report a case of ASN with surrounding pagetoid melanocytic proliferation without formation of tumor nests in the epidermis in the plantar region. A 12-year-old girl presented with a bright red nodule surrounded by a brown macule on the sole of her right foot. Histologically, the nodule showed tumor nests in the dermis, composed of spindle or epithelioid melanocytes containing abundant cytoplasm and large nuclei. Around the nests, numerous blood vessels were seen. In the overlying epidermis of the nodule, numerous eosinophilic Kamino bodies were found along the dermal-epidermal interface. In the macule, proliferation of oval melanocytes was present as single-cell units in the epidermis. Theses melanocytes had abundant cytoplasm with large nuclei, which were larger than those of the surrounding keratinocytes. From these findings, a diagnosis of ASN with surrounding pagetoid melanocytic proliferation was made. Vascular endothelial growth factor and fibroblast growth factor 2 were strongly expressed in the melanocytes as well as in the endothelial cells in our case. Therefore, angiogenic factors produced by the melanocytes of SN might have played important roles in the surrounding angiogenesis of this case.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 96%

Angiomatoid Spitz nevus with surrounding pagetoid melanocytic proliferation on the sole of the foot: An unusual case report with immunohistochemical studies for angiogenic factors

Anju

Nakamura

Okiyama

et al. 2020

The Journal of Dermatology

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Section: Variants Of Spitz Nevimentioning

confidence: 99%

“…Angiomatoid Spitz Nevus is a rare benign variant of SN with less than 10 cases reported ( 150 , 151 ). These lesions are intradermal with no epidermal involvement and are characterized by stromal fibrosis, sparse proliferation of spitzoid melanocytes, and have abundant small, thick-walled blood vessels ( 137 , 150 , 151 ). Because of the numerous blood vessels present in this lesion, it may be confused for an angioma; additionally, the hypervascular stroma may imply a diagnosis of regressed melanoma ( 137 ).…”

Section: Variants Of Spitz Nevimentioning

confidence: 99%

“…Because of shared clinical and histopathologic features, Angiomatoid Spitz Nevus may be considered a subtype of Desmoplastic SN ( 137 , 150 ). The presence of solitary melanocytes rather than nests, stromal fibrosis, low cellular density, and asymptomatic clinical presentation are common between both types of lesions ( 150 , 151 ). High vascularity and lack of spindle cells with hyperchromatic nuclei distinguish Angiomatoid SN from Desmoplastic SN ( 150 ).…”

Section: Variants Of Spitz Nevimentioning

confidence: 99%

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The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification

2022

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Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examination, and several subtypes have been described. We now classify these lesions into benign Spitz nevi, intermediate lesions identified as “atypical Spitz tumors” (or Spitz melanocytoma) and malignant Spitz melanoma. More recently a large body of work has uncovered the molecular underpinning of Spitz tumors, including mutations in the HRAS gene and several gene fusions involving several protein kinases. Here we present an overarching view of our current knowledge and understanding of Spitz tumors, detailing clinical, histopathological and molecular features characteristic of these lesions.

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ROS1 Fusion Angiomatoid Spitz Nevus With Eccrine Duct Fibroadenomatosis and Syringoid Features

Daruish,

Stefanato

2023

The American Journal of Dermatopathology

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Angiomatoid Spitz Nevus

Abstract: Fig. 1. A 0.8 × 0.8 × 0.6 cm pink, slightly pigmented dome-shaped papule on the auricle of the right ear. Angiomatoid Spitz Nevus

Cited by 3 publications

References 6 publications

Angiomatoid Spitz nevus with surrounding pagetoid melanocytic proliferation on the sole of the foot: An unusual case report with immunohistochemical studies for angiogenic factors

Angiomatoid Spitz nevus with surrounding pagetoid melanocytic proliferation on the sole of the foot: An unusual case report with immunohistochemical studies for angiogenic factors

The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification

ROS1 Fusion Angiomatoid Spitz Nevus With Eccrine Duct Fibroadenomatosis and Syringoid Features

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