Angiolymphoid hyperplasia with eosinophilia involving the cubital nerve

Abstract

A tumor involving cubital nerve was resected and studied; it was classified as an angiolymphoid hyperplasia with eosinophilia (ALHE). Immunohistochemical and molecular study was done both to confirm the reactive nature of the process and rule out the presence of clonal T or B cell rearrangement. This lesion has been designated as epitheloid hemangioma [Coindre (1994) Ann Pathol 14:426]. Typically, ALHE occurs in the skin and the subcutaneous tissue, and extracutaneous involvement is rare. No cases of ALHE affecting a nerve have been described, but a case of Kimura's disease, the lesions of which have repeatedly been confused with ALHE, has been reported involving median nerve.

Angiolymphoid hyperplasia with eosinophilia affecting the nail bed and underlying bone

“…Other tissues, such as muscles, nerves, the lacrimal glands, lungs and salivary glands have been rarely reported to be involved. Vascular changes are also seen in ALHE 2–5 …”

“…Vascular changes are also seen in ALHE. [2][3][4][5] There have been a few reports of bone involvement in patients with ALHE. [6][7][8] Two of them dealt with an osteolytic lesion in an extremity that resembled our case.…”

Yaygın Eozinofilik Anjiolenfoid Hiperplazi

“…Kimura hastalığında iyi şekillenmiş lenfoid folliküller ve belirgin eozinofilik infiltrasyon bulunur ancak epiteloid ya da histiositoid endotelial değişiklikler EALH da görüldüğü gibi belirgin değildir. EALH epiteloid endotelial hücre değişiklikleri ile karakterizedir ve lenfoid folliküllerin varlığı nadirdir (11).…”

A Rare Cause of Ptosis in the Upper Eyelid: Angiolymphoid Hyperplasia with Eosinophilia

“…Kimura hastalığında iyi şekillenmiş lenfoid folliküller ve belirgin eozinofilik infiltrasyon bulunur ancak epiteloid ya da histiositoid endotelyal değişiklikler EALH'da gorüldüğü gibi belirgin değildir. EALH epiteloid endotelyal hücre değişiklikleri ile karakterizedir ve lenfoid folliküllerin varlığı nadirdir (8). EAH'nin karakteristik histopatolojik görünümünde kapiller kan damarlarında proliferasyon, damara doğru büyümüş endotelyal hücreler ve perivasküler eozinofil, nötrofil, histiyosit ve mast hücrelerini içerebilen infiltrasyon gözlenmektedir (9).…”