Angiolipomas: An ultrastructural and clinicopathological study

Dixon, Anita; McGregon, Douglas H.; Lee, Saing H.

doi:10.1016/s0046-8177(81)80176-1

Cited by 61 publications

(34 citation statements)

References 15 publications

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“…The nuclei are uniform and there's absence of nuclear hyperchromasia. The microscopy exam exhibited a high vascularization of this fat tissue but wasn't sufficient to include it into the angiolypomas category, the fibrous septa were insufficient to described it as fibrolypoma (11). We excluded also the mixed variants of lipomas, the white fat cells …”

Section: Resultsmentioning

confidence: 99%

Case key about pseudolipomas pathogenesis

Gualdi¹

2014

CDERM

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SummaryIn soft tissues the most common benign tumor is lipoma and has an incidence of 1%. It affects the entire body and both males and female are equally affected, especially in obese patients (1). This neoplastic lesion develops on the fat mesenchimal cells. Predominantly located in the subcutaneous tissue layer, lipomas are rarely present in intermuscular, subfascial, retroperitoneal, mediastinal, gastrointestinal or intraneural areas (2). There are sometimes multiple lipomas, usually painless, asymptomatic, and grow slowly and expand without infiltrating neighboring structures. Pains can occur only when the lesion compresses the nerves causing irritation. When lipomas are located between the skin and the deep fascia, the classical aspect includes a soft, fluctuant feel, lobulation and non adherent of overlying skin. Lipomas are easily removed surgically because they are well demarcated, disc shaped, round or ovoid, lobulated, yellow masses with a doughty consistency (3). Among lipomas literature shows that some of that is different because are not constituted by a surrounding capsule on magnetic resonance imaging (MRI) and histologically less defined as lipomas (4). The first who suggested a relation between traumatic events and development of benign adipose tumors was Adair in 1932. In contrast to lipomas, pseudolipomas are usually encountered with a strong predominance in female patients (12:1). They are often localized at the lower extremity, and in trochanteric and gluteal regions, so pseudolipomas can be defined as a simple adipose tissue in an abnormal location subjected to a trauma (5, 6). Althought this topic are one of the most discussed, the etiology remained unknown, so in literature there are only hypothesis. However, the first description of PTL pathogenetic mechanism was proposed by Brooke and Mc Gregor: they assumed that soft tissue trauma lead to a prolapse of adipose tissue through Scarpa's fascia, and finally to pseudolipoma. Most of the information about the topic comes to us from the exposition of case reports asserting three different pathogenetic hypothesis: mechanical, endocrinological and inflammatory. Our case report confirms the inflammatory one.KEY WORDS: pseudolipoma; post traumatic lipoma; inflammatory theory; squamocellular carcinoma; scalp tumor. MethodsIn December 2010 a 68-year-old male treated for chronic lymphatic leukemia was submitted to a surgical removal of the ulcerated nodular lesion (4x2 cm) in the front-parietal area. The histological exam confirmed the presence of a squamous cell carcinoma poorly differentiated with both lateral and deep borders free of neoplastic remaining (Figure 1). This surgical operation didn't remove the aponeurotic galea. However, for the second time, one year later the patient went to our dermatological and surgical department with a bulky recurrence on the first removal scar (Figure 2). The patient was re-operated in order to remove this neoplastic lesion and in addition, this time, also the aponeurotic galea was removed. In the galea was ...

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Section: Resultsmentioning

confidence: 99%

Case key about pseudolipomas pathogenesis

Gualdi¹

2014

CDERM

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“…6 Of 92 cases of spinal angiolipomas described by Turgut 16 in 2004, six were observed in children. Four of these six cases occurred in boys, in contrast to the adult population, in which a male/ female ratio of 1:1.6 is documented.…”

Section: Discussionmentioning

confidence: 99%

Spinal epidural angiolipoma complicated by an intratumoral abscess

Petrella¹,

Tamburrini²,

Lauriola³

et al. 2005

Journal of Neurosurgery: Pediatrics

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Spinal angiolipomas are rare, benign lesions representing 0.14 to 1.2% of all spinal axis tumors. They most commonly involve the midthoracic spine and are located in the posterior epidural space. Up to now, six pediatric cases have been reported in the literature; two of them involved an acute clinical onset that was related to a venous infarction of a tumor. The authors report the case of a 16-year-old boy with a midthoracic epidural angiolipoma who was admitted with a clinical history of an acute paraparesis. In contrast to previous descriptions, the acute onset in this case was related to a spontaneous intratumoral abscess within the tumor.

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“…A review of the English language medical literature since 1966 has failed to reveal another such case. Two forms of angiolipoma are recognized: infiltrating and noninfiltrating 1–4 . The following discussion will be limited to the noninfiltrating variety.…”

Section: Discussionmentioning

confidence: 99%

Multiple subcutaneous angiolipomas associated with new‐onset diabetes mellitus

2002

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A 44‐year‐old Hispanic man, with a past medical history of diabetes mellitus type 2 and cerebrovascular accident, presented to the Mount Sinai Department of Dermatology with sudden, fast‐growing nodules over both of his shins. Approximately 2 months before the appearance of the nodules, the patient was diagnosed with diabetes mellitus type 2 with hemoglobin A1c (HbA1c) of 8.5%. The patient was taking metformin orally, 500 mg three times daily, at the time of presentation. Six nodules appeared over a period of days. They caused a burning, throbbing pain upon ambulation. Over a period of 6 months, the lumps decreased in size, and two totally disappeared. The resolution of the nodules coincided with the control of the patient's diabetes, as demonstrated by HbA1c of 5.5%. The patient denied trauma to the sites of the nodules. The patient denied any associated purpura or ecchymoses over the nodules. The past medical history was significant for a stroke with residual right hemiparesis at 42 years of age. The family history was negative for similar lesions, but an aunt did have diabetes mellitus type 2. The patient denied alcohol use, smoking, or intravenous drug use. Physical examination was positive for six soft, tender, freely mobile, symmetrical, well‐demarcated, round masses, 1–2 cm in diameter and skin colored, over the anterior aspects of both legs. The patient was obese (body mass index, 38.5). Laboratory tests (barring the initially elevated HbA1c) were normal. One lesion was excised. Histopathology revealed features typical of an angiolipoma (see Fig. 1a,b). A karyotype of the angiolipoma was not performed. 1 (a) Prominent vessels filled with fibrin thrombi at the periphery of mature fat lobules. (b) At higher magnification Because excision of one angiolipoma produced scarring with a poor cosmetic result, intralesional triamcinolone, 5 mg/mL, was tried without success.

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Angiolipomas: An ultrastructural and clinicopathological study

Cited by 61 publications

References 15 publications

Case key about pseudolipomas pathogenesis

Case key about pseudolipomas pathogenesis

Spinal epidural angiolipoma complicated by an intratumoral abscess

Multiple subcutaneous angiolipomas associated with new‐onset diabetes mellitus

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