Angiolipoma Detected by F-18 FDG Positron Emission Tomography

Hsu, Chih Yang; Yang, Che-Ming; CHENG, CHIEH-JUI

doi:10.1097/00003072-200307000-00019

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…In one case, the patient had a focal angiolipoma with increased 18 F-FDG PET uptake in the left lower abdominal wall. The authors thought this might have been due to hypervascularity, blood stasis, and congestion in the vascular structure, which accelerates inflammatory processes and leads to high 18 F-FDG uptake (9). Another case report found high uptake of 68 Ga-PSMA in subcutaneous angiolipoma, but did not provide further in-depth analysis of the potential causes (8).…”

Section: Discussionmentioning

confidence: 98%

“…Angiolipoma is a special type of lipoma that is formed by mixing mature adipose tissue with hyperactive vascular tissue. In the literature, there are only two reports of angiolipomas as determined by 68 Ga-PSMA and fluorodeoxyglucose ( 18 F-FDG) PET/ CT (8,9), although the possible reasons for enhanced uptake of PSMA in these angiolipomas are not explained. Herein, we report a rare case of an elderly male patient with multiple angiolipomas, which were detected by 18 F-PSMA1007 PET/CT.…”

Section: Introductionmentioning

confidence: 99%

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18F-PSMA-1007 PET/CT uptake in multiple angiolipomas caused by PSMA expression in capillaries: a case report

Wang¹,

Tang²,

Yin³

et al. 2021

Transl Androl Urol

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Prostate specific membrane antigen (PSMA) is a transmembrane glycoprotein that was originally cloned in the membrane of prostate gland epithelial cells. It has been confirmed to be highly expressed in prostate cancer cells, and in some non-prostatic tissues, including the brain and some benign lesions. PSMAbased imaging has been extensively used for the assessment of prostate carcinoma. The high uptake of PSMA imaging in these non-prostate cancer lesions may lead to some misdiagnosis. It is of important clinical significance to explore the possible causes of high PSMA uptake in these lesions. Here, we present a case of a 77-year-old man with prostate carcinoma who underwent a whole-body 18 F-PSMA-1007 positron emission tomography/computed tomography (PET/CT) scan for staging. The results of the scan showed intense tracer uptake in both the prostatic bed and in multiple subcutaneous lesions. The subcutaneous lesions were later found to be angiolipomas by histopathological examination. Immunohistochemistry demonstrated strong positive cytoplasmic PSMA staining in lesional prostate cancer cells in prostate carcinoma, and mildto-moderate positive cytoplasmic capillary PSMA staining in angiolipoma fatty density nodules. Our case report therefore demonstrated that 18 F-PSMA-1007 PET/CT uptake in multiple angiolipomas was caused by PSMA expression in capillaries, and further knowledge of PSMA expression in benign lesions may be critical to minimize false-positive findings with 18 F-PSMA-1007 PET/CT imaging.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

18F-PSMA-1007 PET/CT uptake in multiple angiolipomas caused by PSMA expression in capillaries: a case report

Wang¹,

Tang²,

Yin³

et al. 2021

Transl Androl Urol

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“…Some tumors are isodense, likely related to the extended vascularization (25). Angiolipoma can also be detected by using F-18 FDG positron emission tomography (28).…”

Section: Discussionmentioning

confidence: 99%

Spinal Angiolipoma: Case Report and Literature Review

Hungs

Pare

2008

The Journal of Spinal Cord Medicine

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Background/Objective: Spinal angiolipoma (SAL) is an uncommon clinico-pathological entity. Design: Single case report. Methods: Retrospective data analysis. Findings: An obese woman with a 1-year history of progressive spastic paraparesis and acute deterioration underwent magnetic resonance imaging of the thoracic spine, the results of which suggested a tumor compressing the thoracic spinal cord. The histopathological examination of the completely resected tumor revealed an epidural angiolipoma. Conclusions: This case report offers a reminder that SAL should be considered in the differential diagnosis of long-standing, slowly progressive paraparesis. It remains unclear whether an increased body mass index might be a contributing factor to the development of SAL.

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“…We previously reported the FDG-PET characteristics of three types of benign lesions. These consisted of an angiolipoma in the lower abdominal wall [8], a neurofibroma arising from para-spinal soft tissue [9], and a granuloma formed as a post-opera- …”

Section: Discussionmentioning

confidence: 99%

Features of Glucose Metabolism in Pleomorphic Hyalinizing Angiectatic Tumor (PHAT)

Chang¹,

Liang²,

Kung³

et al. 2014

AMI

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Pleomorphic Hyalinizing Angiectatic Tumor (PHAT) is a rare mesenchymal neoplasma. It is a pathological term describing a heterogeneous group of neoplasms of undetermined tumorigenesis and undefined malignancy. Based only on the morphological findings of histopathology, the biological potential of the tumor is indeterminate. Determination of glucose metabolism using FDG-PET revealed mildly increased FDG uptake in the tumor. We propose that FDG accumulation in the ectatic vessel, increased uptake of the pleomorphic cells and/or associated inflammatory cells, and increased permeability of the stroma lead to the imaging feature.

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Angiolipoma Detected by F-18 FDG Positron Emission Tomography

Cited by 8 publications

References 5 publications

18F-PSMA-1007 PET/CT uptake in multiple angiolipomas caused by PSMA expression in capillaries: a case report

18F-PSMA-1007 PET/CT uptake in multiple angiolipomas caused by PSMA expression in capillaries: a case report

Spinal Angiolipoma: Case Report and Literature Review

Features of Glucose Metabolism in Pleomorphic Hyalinizing Angiectatic Tumor (PHAT)

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