Angioleiomyoma Originating from the Ovary of an Eleven-Year-Old Premenarchal Girl

Hsu, Tsuen-Wei; Changchien, Chan-Chao; Huang, Chao‐Cheng; Lin, Hao

doi:10.1159/000113083

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…IVL is a rare benign neoplasm arising from the vascular smooth muscle [ 1 ]. It presents as a painful mass in ~60 % of cases [ 3 ]. IVL is the benign hyperplasia of smooth muscle cells, as is seen in uterine fibroids, but it has propensity to grow and metastasize like a malignant tumor.…”

Section: Discussionmentioning

confidence: 99%

Successful en bloc venous resection with reconstruction and subsequent radiotherapy for 2 consecutive recurrences of intravenous leiomyoma—a case report

et al. 2016

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BackgroundIntravenous leiomyomas are a rare variant of uterine leiomyoma. Although histologically benign, these tumors are associated with a poor prognosis due to propensity for metastasis, high recurrence rate, difficulty of obtaining complete resection, and frequent extension into and along major veins.Case presentationWe describe a 43-year-old patient initially presenting with lower abdominal pain. Clinical examination revealed a large right pelvic mass that was shown by computed tomography (CT) to surround the right external iliac vein, right common iliac vein and distal inferior vena cava. The patient had a history of total abdominal hysterectomy with bilateral ovarian cystectomies for uterine leiomyoma approximately 3 years prior to her presentation. Her past surgical history also included removal of an ovarian endometriosis cyst and right hydrosalpinx. The patient underwent an exploratory laparotomy. Operative findings included complete occlusion of the right iliac vessels and distal vena cava by a large tumor that filled the pelvis and extended to the level of the right kidney. The mass was resected en bloc with the involved veins and synthetic vascular grafts were placed. This highly technical procedure was complicated by hemorrhage requiring a total of 32 units of red blood cells and 2.0 L of plasma. Pathologic examination confirmed intravenous leiomyoma. On Immunohistochemical staining, the tumor cells were positive for CD32, CD34, Vimentin and smooth muscle actin. Eight months after this procedure, the patient again presented with an abdominal mass. She was diagnosed with a pelvic recurrence and noted to have intravascular extension into the left iliac vein and inferior vena cava. For this tumor she underwent radiation treatment with three-dimensional conformal radiation therapy (total dose 4500 cGy). The tumor gradually decreased in size during follow-up and became undetectable by CT.ConclusionsSurgical excision is the mainstay of treatment of intravenous leiomyoma. Radiation therapy may be an effective alternative in patients with unresectable disease or poor surgical candidates.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-015-2045-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Successful en bloc venous resection with reconstruction and subsequent radiotherapy for 2 consecutive recurrences of intravenous leiomyoma—a case report

et al. 2016

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Section: Discussionmentioning

confidence: 99%

“…Only few cases of angioleiomyoma of the female genital tract have been reported in the English literature [1,[3][4][5][6][7][8][9][10][11][14][15][16]. Almost all of them located in uterus and only two cases located in ovary [1,[3][4][5][6][7][8][9][10][11]14,15]. Perhaps they are underreported, because in many cases they are also recognized as benign leiomyomas with an unusual histological appearance [6].…”

Section: Discussionmentioning

confidence: 99%

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Uterine angioleiomyoma causing severe abnormal uterine bleeding

Grigoriadis¹,

Georgios²,

Zygouris³

et al. 2014

Clin. Exp. Obstet. Gynecol.

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Background: Angioleiomyoma or angiomyoma or vascular leiomyoma is an unusual benign mesenchymal neoplasm. The authors present a rare case of large uterine angioleiomyoma causing severe abnormal uterine bleeding. Case: The patient, a 53-year-old, gravida 2, para 2, premenopausal Greek woman presented with a complaint of severe abnormal uterine bleeding. On gynecologic examination there was a palpable pelvic mass. Preoperative computer tomography (CT) of the abdomen and pelvis revealed an intra-abdominal mass 25 x 15 cm with abnormally increased vascularization. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, total omentectomy and elective pelvic lymph node dissection. Histopathology revealed uterine angioleiomyoma. Follow up 84 months after initial surgery showed no evidence of recurrence. Conclusion: Despite the type of surgery, patients with uterine angioleiomyoma have very low risk of recurrence and excellent prognosis.

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“…We read with great interest the paper by Hsu et al [1] regarding the first case of angioleiomyoma (ALM) originating from the ovary of an 11-year-old girl. We are presenting the second case of ALM originating from the ovary of a 42-year-old woman.…”

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confidence: 99%