Angioleiomioma de septo nasal

Júnior, Carlos Roberto Ribeiro Navarro; Fonseca, Adriano Santana; Mattos, José Rodrigo Lordello de; Andrade, Nilvano Alves de

doi:10.1590/s1808-86942010000500027

Cited by 8 publications

(10 citation statements)

References 5 publications

(4 reference statements)

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“…Angioleiomyoma usually occurs in the subcutis of extremities, often developing in lower extremities, and presents as a solitary, small, painful, cutaneous solid-type mass. Angioleiomyoma located in the nasal cavity is uncommon, and studies of nasal angioleiomyoma with >2 patients are extremely rare (1–29). To the best of our knowledge, the cases of ~50 patients with nasal angioleiomyoma have been reported in the literature since the first case was reported by Maesaka et al in 1966 (5).…”

Section: Introductionmentioning

confidence: 99%

“…Angioleiomyomas of the nasal cavity typically grow slowly and the majority of these tumors measure <2 cm in size (6–29). Patients may remain asymptomatic for a long time, and may present with nasal obstruction, recurrent epistaxis, nasal discharge, facial pain and headache (6–29).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Patients may remain asymptomatic for a long time, and may present with nasal obstruction, recurrent epistaxis, nasal discharge, facial pain and headache (6–29). The peak incidence of angioleiomyomas of the nasal cavity is between the third and sixth decades of life and the tumor is more common in women (6–29). Angioleiomyoma is rarely diagnosed prior to surgery, as the physical and radiological findings are not tumor-specific in the majority of cases (5–12).…”

Section: Introductionmentioning

confidence: 99%

“…The advent of nasal endoscopes has opened new avenues for surgeons to deal with these tumors. In general, the majority of tumors can be totally excised through the transnasal endoscopic approach, while a smaller number of cases may be removed with craniofacial resection (2,11,26,29). …”

Section: Introductionmentioning

confidence: 99%

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Expression of estrogen and progesterone receptors in angioleiomyoma of the nasal cavity of six patients

2016

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Angioleiomyoma of the nasal cavity is extremely rare. There are only a small number of studies in the literature that demonstrate that the estrogen receptor (ER) and progesterone receptor (PR) are expressed in angioleiomyoma, and the results from these studies are inconsistent. The present study identified 6 patients with nasal angioleiomyoma that were treated between 2004 and 2013. All patients underwent endoscopic surgery and were followed-up for 1–10 years. Resected tumors were investigated for the presence of ER and PR using immunoperoxidase staining. Of the 6 patients, 4 were men and 2 were woman. The mean age of the patients was 60.5 years. The tumors of the 6 patients were identified in the nasal septum, middle turbinate, inferior turbinate, lateral wall of the nasal cavity and nasal vestibule. The clinical manifestations reported by the patients consisted of a painless mass, recurrent epistaxis and nasal obstruction. There were no specific features observed in any of the patients using computed tomography or magnetic resonance imaging. All the patients underwent tumor dissection visualized with a nasal endoscope and recovered without recurrence or malignancy of the tumor post-surgery. Hematoxylin and eosin and immunoperoxidase staining confirmed the diagnosis of angioleiomyoma in all patients. In 5 patients the nuclei of the smooth muscle tumor cells markedly expressed ER and PR. To the best of our knowledge, the present study is the first to demonstrate that ER and PR are clearly expressed in nasal angioleiomyoma. The present study suggests that the sex hormones are possibly associated with the growth of angioleiomyoma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of estrogen and progesterone receptors in angioleiomyoma of the nasal cavity of six patients

2016

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Angioleiomyoma of the Sinonasal Tract: Analysis of 16 Cases and Review of the Literature

Agaimy

Thompson

2015

Head and Neck Pathol

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Angioleiomyoma (ALM; synonyms: angiomyoma, vascular leiomyoma) is an uncommon benign tumor of skin and subcutaneous tissue. Most arise in the extremities (90 %). Head and neck ALMs are uncommon (~10 % of all ALMs) and those arising beneath the sinonasal tract mucosa are very rare (<1 %) with 38 cases reported so far. We herein analyzed 16 cases identified from our routine and consultation files. Patients included seven females and nine males aged 25-82 years (mean 58; median 62). Symptoms were intermittent nasal obstruction, sinusitis, recurrent epistaxis, and a slow-growing mass. Fifteen lesions originated within different regions of the nasal cavity and one lesion was detected incidentally in an ethmoid sinus sample. Size range was 6-25 mm (mean 11). Histologically, all lesions were well circumscribed but non-encapsulated and most (12/16) were of the compact solid type superficially mimicking conventional leiomyoma but contained numerous compressed muscular veins. The remainder were of venous (2) and cavernous (2) type. Variable amounts of mature fat were observed in four cases (25 %). Atypia, necrosis, and mitotic activity were absent. Immunohistochemistry showed consistent expression of smooth muscle actin (12/12), h-caldesmon (9/9), muscle-specific actin (4/4), variable expression of desmin (11/14) and CD56 (4/6), and absence of HMB45 expression (0/11). The covering mucosa was ulcerated in 6 cases and showed squamous metaplasia in one case. There were no recurrences after local excision. Submucosal sinonasal ALMs are rare benign tumors similar to their reported cutaneous counterparts with frequent adipocytic differentiation. They should be distinguished from renal-type angiomyolipoma. Simple excision is curative.

Angioleiomioma de septo nasal

Cited by 8 publications

References 5 publications

Expression of estrogen and progesterone receptors in angioleiomyoma of the nasal cavity of six patients

Expression of estrogen and progesterone receptors in angioleiomyoma of the nasal cavity of six patients

Angioleiomyoma of the Sinonasal Tract: Analysis of 16 Cases and Review of the Literature

Angioleiomyoma of nasal septum: Case report and literature review

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