Angiokeratoma circumscriptum of the tongue

Vijaikumar, M; Thappa, Devinder Mohan; Karthikeyan, Kaliaperumal; Jayanthi, S.

doi:10.1046/j.1525-1470.2003.20221_2.x

Cited by 16 publications

(24 citation statements)

References 8 publications

(11 reference statements)

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“…However, the oral mucosa is very seldom involved in other types of angiokeratoma3,4. In addition to the present case, a review of the literature revealed ten cases of isolated angiokeratoma that occurred in the oral cavity.…”

Section: Discussionmentioning

confidence: 53%

“…(Table 1) Of those, four cases were solitary angiokeratoma and six were angiokeratoma circumscriptum. Except for one case of solitary angiokeratoma that involved the buccal mucosa6, the remaining nine occurred on the tongue (pathologically, six were angiokeratoma circumscriptum and three were solitary angiokeratoma)3,4,5,7,8,9,10,11,12. To our knowledge, the present report is the second case published on isolated oral angiokeratoma confined to the buccal mucosa and the first case report on angiokeratoma circumscriptum involving the buccal mucosa.…”

Section: Discussionmentioning

confidence: 62%

“…The pathogenesis of angiokeratoma is still unknown. It has been thought that altered hemodynamics, such as local injury to papillary capillaries, cause telangiectatic lesions in the papillary dermis with overlying reactive hyperkeratosis and acanthosis of the epidermis3,4. Interestingly, matrix metalloproteinase-9 (MMP-9) has been identified in the epidermis, particularly in hyperkeratotic lesions of angiokeratoma circumscriptum, by immunohistochemistry15.…”

Section: Discussionmentioning

confidence: 99%

“…In the majority of cases, it is also associated with epidermal reactions such as acanthosis and/or hyperkeratosis1. This disorder can be classified into five types: (1) a generalized systemic form (angiokeratoma corporis diffusum of Fabry); (2) a bilateral form occurring on the dorsal surfaces of the fingers and toes (angiokeratoma of Mibelli); (3) a localized scrotal form (angiokeratoma of Fordyce); (4) a solitary papular angiokeratoma; and (5) a multiple papular and plaque-like form (angiokeratoma circumscriptum)2,3. Although the clinical characteristics are different, common histological features include hyperkeratosis of the epidermis and dilated vascular spaces with or without organizing thrombi in the papillary dermis of cutaneous lesions4,5.…”

Section: Introductionmentioning

confidence: 99%

“…Isolated oral angiokeratoma unrelated to any systemic disease or cutaneous lesion has been rarely reported. To the best of our knowledge, only ten cases of isolated angiokeratoma in the oral cavity have been reported in the literature3,4,5,6,7,8,9,10,11,12. (Table 1) The majority of reported oral angiokeratoma cases occurred on the tongue, but one case involved the buccal mucosa.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review

Kang

Byun

Park

2014

J Korean Assoc Oral Maxillofac Surg

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Angiokeratoma is a benign cutaneous lesion of the capillaries, presenting as dilated vessels in the upper part of the dermis. Although this disorder is classified into various types and has been occasionally reported in the skin of the scrotum or extremities, the involvement of the oral cavity mucosa has been rarely reported. The present study reports a case of angiokeratoma circumscriptum in the buccal mucosa. The expression of vascular endothelial growth factor (VEGF) and both of its receptors (VEGFR-1 and VEGFR-2) was demonstrated by immunohistochemistry in the endothelial cells lining the dilated vessels. The expression of VEGFR-2 was higher than that of VEGFR-1 in the endothelial cells in the lesion, indicating an increased rate of endothelial cell proliferation within the lesion. Interestingly, some of the endothelial cells co-expressed VEGF and its two receptors. These results suggest that endothelial cells in the pathologically dilated vessels possess VEGF autocrine growth activity involved in vasculogenesis and maintenance in angiokeratoma lesions. To our knowledge, this is the second report published on isolated oral angiokeratoma confined to the buccal mucosa and the first case report on angiokeratoma circumscriptum involving the buccal mucosa.

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Section: Discussionmentioning

confidence: 53%