Angioimmunoblastic T-cell lymphoma in bone marrow: a morphologic and immunophenotypic study

Khokhar, Faisal A; Payne, William D.; Talwalkar, Sameer S.; Jorgensen, Jeffrey L.; Bueso‐Ramos, Carlos E.; Medeiros, L. Jeffrey; Vega, Francisco

doi:10.1016/j.humpath.2009.06.016

Cited by 28 publications

(12 citation statements)

References 28 publications

(50 reference statements)

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“…In LNs, the presence of B-cells and follicular dendritic cells supports the expression of follicular helper T-cell-associated antigens including CD10, CXCL13, BCL6 and ICOS and the absence or altered microenvironment in the blood and BM may, in part, contribute to the less frequent expression of CD10 when compared with LN. An earlier study of AITL by Khokhar and colleagues [9] used immunohistochemistry and flow cytometry to assess BM specimens and showed that most of the neoplastic cells were negative for CXCL13 and approximately 75% of their cases were negative for CD10. To this effect, Attygalle and colleagues also have reported an association between the presence of follicular dendritic cells and expression of CD10 in the BM [18].…”

Section: Discussionmentioning

confidence: 99%

Immunophenotypic and diagnostic characterization of angioimmunoblastic T-cell lymphoma by advanced flow cytometric technology

Loghavi

Wang

Medeiros

et al. 2016

Leukemia & Lymphoma

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AITL often shows systemic symptoms related to immune dysregulation and cytokine production. Biopsy harbors few malignant cells in abundant reactive background, diagnostically challenging in small biopsies. This study was to assess the value of flow cytometry (FC) and to determine the immunophenotypic alterations in 144 samples from 38 patients. FC detected an aberrant T-cell population in 97/144 samples that represented 0.5-90% of lymphocytes. Blood was involved in 11/16 patients. The most frequent immunophenotypic aberrancies included loss of CD3; altered T-cell receptor expression and aberrant CD10 expression. Altered CD3 expression was more frequently seen in PB and BM whereas aberrant CD10 expression was more common in LN. AITL cells often exhibit abnormal CD4+ immunophenotype with diminished or absent CD3 and variable CD10 expression. Multiparameter FC is an effective tool for supporting the diagnosis of AITL in any fluid and tissue specimens.

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Section: Discussionmentioning

confidence: 99%

Immunophenotypic and diagnostic characterization of angioimmunoblastic T-cell lymphoma by advanced flow cytometric technology

Loghavi

Wang

Medeiros

et al. 2016

Leukemia & Lymphoma

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“…In the central nervous system of EAE-induced mice, Tfh-like cells aberrantly co-express Th17-relevant genes (74), and Tfh-like cells have also been found in bone marrow samples from human patients of angioimmunoblastic T-cell lymphoma (108). Assessment of germinal center T-cell phenotypes is often performed in cells derived from lymph node or spleens.…”

Section: Perspectivesmentioning

confidence: 99%

“…Bcl6-expressing T cells also exist in Peyer's patches in the gut, where these cells can differentiate from CD4 + T cells that express FoxP3 (107), although they may not be stable Treg cells. In the central nervous system of EAE-induced mice, Tfh-like cells aberrantly co-express Th17-relevant genes (74), and Tfh-like cells have also been found in bone marrow samples from human patients of angioimmunoblastic T-cell lymphoma (108).…”

Section: Perspectivesmentioning

confidence: 99%

T‐cell subsets in the germinal center

Ramiscal

Vinuesa

2013

Immunological Reviews

160

155

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T cells are known to migrate to B-cell-enriched follicles and germinal centers within secondary lymphoid organs to provide help to B cells. Cognate T:B interactions that take place at the T:B border and subsequently within germinal centers are essential for B-cell priming, differentiation into germinal center B cells, and selection of mutated cells into memory B cells or memory plasma cells. In recent years, different stages of maturation within B-cell helper T cells, collectively known as B-follicular helper T (Tfh) cells, as well as heterogeneity amid germinal center T cells are becoming clear. Indeed, germinal centers support not only bona fide Tfh cells but also CD4(+) and CD8(+) follicular regulatory T (Tfr) cells that act to suppress germinal center responses and B-cell helper natural killer T cells. There is a growing need for more precise phenotypic and functional distinction of these specialized T-cell subsets. In this review, we summarize current knowledge on the ontogeny, molecular identity, and functional relevance of the various subsets of germinal center T cells.

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“…23 A similar BM histopathology also extends to other B-cell malignancies (for example, T-cell/histiocyte-rich diffuse large B-cell lymphoma) and T-cell lymphomas of follicular derivation (angioimmunoblastic T-cell lymphoma). 24–26 The extracellular meshwork of lymphoid follicles is associated with the stromal follicular dendritic cell and microvascular network, and shares several components with that of the BM osteoblastic niche, including integrin-β 1 , type I collagen, and matricellular protein expression. 27,28 These elements might provide a common adhesive background to neoplastic cells by favoring their location in the BM osteoblastic compartment, and signaling through the Notch stromal ligands Delta-like-1 and Jagged-1.…”

Section: The Bm Stroma In Lymphoid Neoplasmsmentioning

confidence: 99%

The bone marrow stroma in hematological neoplasms—a guilty bystander

Tripodo

Sangaletti

Piccaluga³

et al. 2011

Nat Rev Clin Oncol

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In the setting of hematological neoplasms, changes in the bone marrow (BM) stroma might arise from pressure exerted by the neoplastic clone in shaping a supportive microenvironment, or from chronic perturbation of the BM homeostasis. Under such conditions, alterations in the composition of the BM stroma can be profound, and could emerge as relevant prognostic factors. In this Review, we delineate the multifaceted contribution of the BM stroma to the pathobiology of several hematological neoplasms, and discuss the impact of stromal modifications on the natural course of these diseases. Specifically, we highlight the involvement of BM stromal components in lymphoid and myeloid malignancies, and present the most relevant processes responsible for remodeling the BM stroma. The role of bystander BM stromal elements in the setting of hematological neoplasms is discussed, strengthening the rationale for treatment strategies that target the BM stroma.

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Angioimmunoblastic T-cell lymphoma in bone marrow: a morphologic and immunophenotypic study

Cited by 28 publications

References 28 publications

Immunophenotypic and diagnostic characterization of angioimmunoblastic T-cell lymphoma by advanced flow cytometric technology

Immunophenotypic and diagnostic characterization of angioimmunoblastic T-cell lymphoma by advanced flow cytometric technology

T‐cell subsets in the germinal center

The bone marrow stroma in hematological neoplasms—a guilty bystander

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