Angioid streaks. I. Ophthalmoscopic variations and diagnostic problems.

Shields, Jerry A.; Federman, Jay L.; Tomer, Terrance L.; Annesley, William H.

doi:10.1136/bjo.59.5.257

Cited by 87 publications

(34 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CNV is reported to occur in up to 86% of patients with serious visual consequences, particularly as it affects people of working age. 1,2 Studies have shown that the majority of untreated patients with CNV secondary to AS develop a significant visual impairment resulting in legal blindness. [4][5][6][7][8] Although various treatment options are available for AS-related CNV, to date most published trials have involved either laser photocoagulation or PDT.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Intravitreal ranibizumab for the treatment of choroidal neovascularisation secondary to angioid streaks

Shah

Amoaku

2012

Eye

View full text Add to dashboard Cite

Aims To assess the medium to long-term efficacy and safety of intravitreal ranibizumab for the treatment of choroidal neovascularisation (CNV) secondary to angioid streaks (AS). Methods A total of 12 eyes of nine patients treated with intravitreal ranibizumab (0.5 mg in 0.05 ml) for CNV secondary to AS were retrospectively identified. Efficacy of treatment was determined by changes in best-corrected LogMAR visual acuity (BCVA) and optical coherence tomography. Changes with respect to baseline BCVA were defined as improved or reduced with a gain or loss of more than 10 letters, respectively, or stable if remaining within 10 letters. Results Over a mean follow-up of 21.75 months (range: 1-54), patients received mean 5.75 (range: 2-15) intravitreal ranibizumab injections per affected eye. BCVA improved in three eyes (25%), stabilised in eight eyes (66.67%), and deteriorated in one eye (8.33%). There was no significant change in central retinal thickness (CRT) over the follow-up period (P ¼ 0.1072). No drug-related systemic side effects were recorded. Conclusion The long-term treatment of CNV secondary to AS with intravitreal ranibizumab showed a stabilisation in CRT and an improvement or stabilisation of BCVA. The absence of systemic side effects was reassuring. Further long-term prospective studies are required to validate these findings.

show abstract

Section: Discussionmentioning

confidence: 99%

“…1,2 Choroidal neovascularisation (CNV) is one of the commonest complications of AS and has been reported to occur in 70-86% of patients, with up to 71% developing CNV in the fellow eye. 2 AS are rare with a reported annual incidence of AS-related CNV at 0.057 per 100 000 population in United Kingdom.…”

Section: Introductionmentioning

confidence: 99%

Intravitreal ranibizumab for the treatment of choroidal neovascularisation secondary to angioid streaks

Shah

Amoaku

2012

Eye

View full text Add to dashboard Cite

show abstract

“…The diagnosis of PXE was based on characteristic systemic manifestation including fundus findings in photographs as well as FA as described by Shields et al 11 The diagnosis was then further confirmed by characteristic histopathological abnormalities in skin biopsy. Eyes with opaque media (eg, cataracts) and vitreous haemorrhage were excluded from analysis.…”

Section: Methodsmentioning

confidence: 99%

“…They lead to poor visual prognosis, especially when the CNV involves the macular area. 6,8,[10][11][12] The efficacy of various treatment modalities, including laser photocoagulation, transpupillary thermotherapy, PDT with verteporfin, and rarely macular translocation, is limited and even worse in eyes with CNV secondary to AS compared with those secondary to AMD (age-related macular degeneration). 7,9,[13][14][15][16][17][18] It is useful to identify the differences in the fundus lesions that underline the different responses to treatment between these diseases.…”

Section: Introductionmentioning

confidence: 99%

Tomographic fundus features in pseudoxanthoma elasticum: comparison with neovascular age-related macular degeneration in Japanese patients

Ellabban

Hangai

Yamashiro

et al. 2012

Eye

View full text Add to dashboard Cite

Purpose To determine the retinal and subretinal features characteristic to pseudoxanthoma elasticum (PXE) compared with age-related macular degeneration by using spectral-domain optical coherence tomography (SD-OCT) in Japanese patients. Methods We reviewed colour fundus photographs, fluorescein angiograms, and SD-OCT images of 52 eyes (27 Japanese patients) with angioid streaks (AS) due to PXE. Then we compared the incidence of tomographic features between 24 eyes (24 patient) with choroidal neovascularization (CNV) secondary to AS and 44 eyes (44 patients) with CNV secondary to age-related macular degeneration (AMD). Results Secondary CNV was found in 44 eyes (84.6%) of 52 patients with PXE during follow-up. We found characteristic round or ovoid tubular structures with highly reflective annular lines (termed 'outer retinal tubulation' (ORT)) in 31 (70.5%) of 44 eyes with CNV, but none were found in eyes without CNV. We also found characteristic undulations of Bruch's membrane in 38 (73.1%) eyes with AS. The incidence of ORT was significantly greater in eyes with CNV secondary to AS (70.8%; P ¼ 0.005) compared with eyes with CNV secondary to AMD (34.1%). The incidence of Bruch's membrane undulation was significantly greater in eyes with CNV secondary to AS (70.8%; Po0.0001) than in eyes with CNV secondary to AMD (11.4%).Conclusion SD-OCT imaging clearly revealed a greater incidence of unique lesions, including ORT and Bruch's membrane undulation, in eyes in PXE patients with CNV secondary to AS than in eyes with CNV secondary to AMD.

show abstract

“…A justificativa é a grande incidência de NVC que ocorre em 72 a 86% dos pacientes implicando em baixa AV central (7) . Em nosso estudo observamos 67,6% de NVC ativas ou cicatrizadas.…”

Section: Discussionunclassified