Angioid Streaks

Federman, Jay L.; Shields, Jerry A.; Tomer, Terrance L.

doi:10.1001/archopht.1975.01010020749003

Cited by 17 publications

(2 citation statements)

References 19 publications

(1 reference statement)

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“…Several authors have presented and discussed the fluorescein angiographic findings of angioid streaks (Smith et al, 1964; Patnaik and Malik, 1971; Federman et al, 1975). In the absence of other signs of CNV, however, fluorescein angiography does not usually add clinically relevant information and therefore may be refrained from in asymptomatic patients.…”

Section: Added Value Of Retinal Imagingmentioning

confidence: 99%

An update on the ocular phenotype in patients with pseudoxanthoma elasticum

Gliem¹,

Zaeytijd²,

Finger³

et al. 2013

Front. Genet.

121

206

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Pseudoxanthoma elasticum (PXE) is an inherited multi-system disorder characterized by ectopic mineralization and fragmentation of elastic fibers in the skin, the elastic laminae of blood vessels and Bruch’s membrane in the eye. Biallelic mutations in the ATP-binding cassette (ABC) transporter gene ABCC6 on chromosome 16 are responsible for the disease. The pathophysiology is incompletely understood. However, there is consent that a metabolic alteration leads to dysfunction in extracellular calcium homeostasis and subsequent calcification of connective tissues rich in elastic fibers. This review summarizes and aims at explaining the variety of phenotypic ocular findings in patients with PXE. Specialized imaging techniques including white light fundus photography, blue light autofluorescence, near-infrared confocal reflectance imaging, high resolution optical coherence tomography, fluorescein and indocyanine green (ICG) angiography have revealed characteristic lesions at the ocular fundus of PXE patients. These include the classic signs of angioid streaks, peau d’orange, comet lesions, and choroidal neovascularizations (CNVs), but also the more recently recognized features such as chorioretinal atrophy, subretinal fluid independent from CNV, pattern dystrophy-like changes, debris accumulation under the retinal pigment epithelium, reticular drusen and a decreased fluorescence on late phase ICG angiography.

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Section: Added Value Of Retinal Imagingmentioning

confidence: 99%

An update on the ocular phenotype in patients with pseudoxanthoma elasticum

Gliem¹,

Zaeytijd²,

Finger³

et al. 2013

Front. Genet.

121

206

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“…The light emitted by the excited fluorescein molecules is captured by a film in the FFA apparatus, and the signal is then reconstructed to give an assessment of the retinal vasculature [ 1 ]. FFA plays a pivotal role in the confirmation of the existence of a secondary CNV [ 3 , 95 , 96 , 97 , 98 ]. Nevertheless, in asymptomatic AS patients, it does not add much more to the diagnosis or treatment [ 5 ].…”

Section: Narrative Review Findingsmentioning

confidence: 99%

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Tsokolas,

Tossounis,

Tyradellis

et al. 2024

Vision

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Aim: Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch’s membrane. This objective narrative review aims to provide an overview of pathophysiology, current treatment modalities, and future perspectives on this condition. Materials and Methods: A literature search was performed using “PubMed”, “Web of Science”, “Scopus”, “ScienceDirect”, “Google Scholar”, “medRxiv”, and “bioRxiv.” Results: ASs may be idiopathic, but they are also associated with systemic conditions, such as pseudoxanthoma elasticum, hereditary hemoglobinopathies, or Paget’s disease. Currently, the main treatment is the use of anti-vascular endothelial growth factors (anti-VEGF) to treat secondary CNV, which is the major complication observed in this condition. If CNV is detected and treated promptly, patients with ASs have a good chance of maintaining functional vision. Other treatment modalities have been tried but have shown limited benefit and, therefore, have not managed to be more widely accepted. Conclusion: In summary, although there is no definitive cure yet, the use of anti-VEGF treatment for secondary CNV has provided the opportunity to maintain functional vision in individuals with AS, provided that CNV is detected and treated early.

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Angioid Streaks

Starr

Chen

et al. 2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Angioid Streaks

Cited by 17 publications

References 19 publications

An update on the ocular phenotype in patients with pseudoxanthoma elasticum

An update on the ocular phenotype in patients with pseudoxanthoma elasticum

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Angioid Streaks

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