Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans

Braaf, Boy; Vermeer, Koenraad A.; Vienola, Kari V.; Boer, Johannes F. de

doi:10.1364/oe.20.020516

Cited by 114 publications

(117 citation statements)

References 47 publications

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“…The color-coded angiogram can be superimposed on a gray-scale, cross-sectional, structural OCT image to demonstrate blood flow and structural information simultaneously. Flow projection artifacts are a common problem for existing OCT angiography techniques (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). To better distinguish and interpret the blood flow within different layers, a negative filter was used to mask projection artifacts from the larger caliber retinal vessels (24).…”

Section: Discussionmentioning

confidence: 99%

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Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

Jia

Bailey

Hwang

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

592

469

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Retinal vascular diseases are important causes of vision loss. A detailed evaluation of the vascular abnormalities facilitates diagnosis and treatment in these diseases. Optical coherence tomography (OCT) angiography using the highly efficient split-spectrum amplitude decorrelation angiography algorithm offers an alternative to conventional dye-based retinal angiography. OCT angiography has several advantages, including 3D visualization of retinal and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related complications. Results from six illustrative cases are reported. In diabetic retinopathy, OCT angiography can detect neovascularization and quantify ischemia. In age-related macular degeneration, choroidal neovascularization can be observed without the obscuration of details caused by dye leakage in conventional angiography. Choriocapillaris dysfunction can be detected in the nonneovascular form of the disease, furthering our understanding of pathogenesis. In choroideremia, OCT's ability to show choroidal and retinal vascular dysfunction separately may be valuable in predicting progression and assessing treatment response. OCT angiography shows promise as a noninvasive alternative to dye-based angiography for highly detailed, in vivo, 3D, quantitative evaluation of retinal vascular abnormalities.optical coherence tomography angiography | ophthalmic imaging | ocular circulation O ptical coherence tomography (OCT) has become the most commonly used imaging modality in ophthalmology. It provides cross-sectional and 3D imaging of the retina and optic nerve head with micrometer-scale depth resolution. Structural OCT enhances the clinician's ability to detect and monitor fluid exudation associated with retinal vascular diseases. Whereas anatomical alterations that impact vision are readily visible, structural OCT has a limited ability to image the retinal or choroidal vasculatures. Furthermore, it is unable to directly detect capillary dropout or pathologic new vessel growth (neovascularization) that are the major vascular changes associated with two of the leading causes of blindness, age-related macular degeneration (AMD) and diabetic retinopathy (1). To visualize these changes, traditional i.v. contrast dye-based angiography techniques are currently used.Fluorescein dye is primarily used to visualize the retinal vasculature. A separate dye, indocyanine green (ICG), is necessary to evaluate the choroidal vasculature. Both fluorescein angiography (FA) and ICG angiography require i.v. injection, which is time consuming, and which can cause nausea, vomiting, and, rarely, anaphylaxis (2). Dye leakage or staining provides information regarding vascular incompetence (e.g., from abnormal capillary growth), but it also obscures the image and blurs the boundaries of neovascularization. Additionally, conventional angiography is 2D, which makes it difficult to distinguish vascular abnormalities within different layers. Therefore, it is desirable to develop a no-injection, dye-free method...

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Section: Discussionmentioning

confidence: 99%

“…Initially, Doppler OCT angiography methods were investigated for the visualization and measurement of blood flow (3)(4)(5)(6)(7)(8). Because Doppler OCT is only sensitive to motion parallel to the OCT probe beam, it is limited in its ability to image retinal and choroidal circulations, which are predominantly perpendicular to the OCT beam.…”

mentioning

confidence: 99%

Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

Jia

Bailey

Hwang

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

592

469

View full text Add to dashboard Cite

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“…Furthermore, high speed enables specific Doppler analysis methods, 131 enhanced velocity bandwidth, 132,133 as well as the possibility of using flexible scanning patterns to further increase the velocity sensitivity. 134,135 In general, flow contrasting requires comparing two or more scans preferably taken at the same location. The velocity sensitivity of the contrasting technique scales with the time difference between the scans.…”

Section: Label-free Optical Angiographymentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

418

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Thus even small details like capillaries which have an extension below the transverse resolution of the system can be visualized although these appear larger than their true extension in the images [17]. Using multiphoton microscopy in comparison with OCTA these differences have been investigated in brain tissue [18].…”

Section: Introductionmentioning

confidence: 99%

Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics

Salas

Augustin

Ginner

et al. 2016

Biomed. Opt. Express

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Abstract:The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some limitations of this technology such as shadowing and projection artifacts caused by overlying vasculature or the inability to determine the true extension of a vessel. Thus, the evaluation of the vascular structure and density based on OCTA alone can be misleading. In this paper we compare the performance of AO-OCT, AO-OCTA and OCTA for imaging retinal vasculature. The improved transverse resolution and the reduced depth of focus of AO-OCT and AO-OCTA greatly reduce shadowing artifacts allowing for a better differentiation and segmentation of different vasculature layers of the inner retina. The comparison is done on images recorded in healthy volunteers and in diabetic patients with distinct pathologies of the retinal microvasculature.

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Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans

Cited by 114 publications

References 47 publications

Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

Optical coherence tomography today: speed, contrast, and multimodality

Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics

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