Angiographic Severity of Coronary Artery Disease in Diabetic and Non-Diabetic Patients in a Tertiary Care Centre

Parvin, Tanjima; Haque, Kmhs Sirajul; Siddique, Abu; Habib, SM Ahsan; Rahman, Mukhlesur; Rahman, Mohammad Hafizur; Sultan, Ashraf Uddin; Hoque, Harisul

doi:10.3329/uhj.v10i1.24590

Cited by 7 publications

(9 citation statements)

References 11 publications

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“…The reason may be due to the fact that prolonged and uncontrolled hyperglycemia causes more rapid and increased athererogenesis. Our results are comparable with studies conducted by Hegde et al and Malthesh et al 6,25 As far as the treatment outcome of our study group is concerned most of the diabetic CAD patients were advised to undergo CABG and this observation is well correlated with poor glycaemic control and prolonged duration of diabetes, whereas most of the non diabetic CAD patients were advised for adequate medical management followed by staged interventions.…”

Section: Risksupporting

confidence: 91%

“…20,21 vessel occlusions than mild and moderate stenosis (47.9% vs. 14%), whereas in non diabetic group there was almost equal distribution, with slightly high proportion of mild stenosis. 6,7,9,10,12,[23][24][25][26] Similar findings were observed in various studies conducted comparing severity of stenosis among diabetics and non diabetics. 24,[27][28][29] On subgroup analysis of only diabetic CAD patients (N=71) we found, 11.2% prevalence of CAD at the time of diagnosing diabetes.…”

Section: Risksupporting

confidence: 62%

“…But this ratio was drastically reduced to 2:1 in diabetic CAD patients, suggesting that females with diabetes are more prone to develop CAD, compared with their counterparts in non diabetic group and this observation is well comparable with other studies. 6,14 This wide gender difference in the present study may be due the fact that in females there were According to the Framingham heart study, the traditional and established modifiable risk factors of coronary artery disease were hypertension, obesity, diet, sedentary lifestyle, dyslipidemia, and smoking. In our study we found hypertension, dyslipidemia, obesity and smoking as major risk factors in patients with coronary artery disease.…”

Section: Resultsmentioning

confidence: 60%

“…Many other studies also showed higher prevalence of hypertension among diabetic CAD. 6,7,11,15,16 On searching the literature, we found a renowed entity called diabetic dyslipidemia, where in there is a combination of raised triglycerides and LDL cholesterol and decreased HDL cholesterol in diabetic patients. Study done by Pandya et al in the same geographical area on the prevalence and pattern of dyslipidemia among type 2 diabetes, found very high prevalence (82.9%) of diabetic dyslipidemia and having mixed pattern of dyslipidemia, with most of them having a raised triglycerides and LDL cholesterol levels.…”

Section: Resultsmentioning

confidence: 99%

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Diabetic CAD versus non diabetic CAD: a comparative study of clinical features, risk factors and angiographic profile

Sareddy¹,

Pandya

Sumple³

et al. 2021

Int J Adv Med

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Background: Current study was conducted to compare clinical, risk factor profile and angiographic features of diabetic and non diabetic patients with coronary artery disease.Methods: This case control study was carried out in 142 patients, who had angiographically proven CAD. 71 patients with diabetes or newly detected with diabetes constituted the cases and remaining controls. Necessary data was collected. Standard statistical analytics were used and risk factor and investigatory profile, including ECG, 2D ECHO and coronary angiography were compared between diabetic and non diabetic CAD patients.Results: Mean age of occurrence of CAD was 52.15+6.81, with no significant difference in mean age among groups. Higher prevalence of CAD was seen in female diabetics. Hypertension, dyslipidaemia, obesity and smoking were found as major risk factors of CAD. Atypical chest pain and silent ischemia were most common among diabetic CAD. Multiple vessel involvement (47.9% vs. 18.3%, p <0.01) is more common in diabetics. Prolonged duration of diabetes and poor glycemic control were associated with more severe and extensive form of CAD (p<0.05) and the treatment outcome in the form of CABG (p<0.01).Conclusions: Diabetic CAD patients were more likely to have severe, extensive coronary artery involvement. Significant number of diabetics had asymptomatic ischemia, with normal ECG and 2D echo, emphasizing the need of extensive cardiac evaluation at an early stage. Hypertension, dyslipidaemia, female gender along with uncontrolled and prolonged duration of diabetes, caused more critical form of CAD and poor treatment outcomes in the form of CABG.

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Section: Risksupporting

confidence: 91%

Section: Risksupporting

confidence: 62%

Section: Resultsmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 99%

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Diabetic CAD versus non diabetic CAD: a comparative study of clinical features, risk factors and angiographic profile

Sareddy¹,

Pandya

Sumple³

et al. 2021

Int J Adv Med

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“…In a study by Tanjima Parvin et al [21] 102 patients who had CAD and underwent coronary angiography were studied. In their study Left main stem disease (21% versus 5%, p 0.031) and three-vessel disease (50% versus 31%, p 0.094) were more prevalent in diabetic patients.…”

Section: Association Between Vessels Involved and Hba1cmentioning

confidence: 99%

A Study on Glycaemic Status Impact in Acute Coronary Syndrome

Rajuri¹,

Priyanka²

2019

jemds

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BACKGROUND Coronary Artery Disease is the leading cause of death worldwide currently, resulting in around 7 million deaths per year and can rise by 40% around 2020. The prevalence of CAD and the incidence of ACS also are very high and occurs 5-10 years earlier among Indians. The overall cardiovascular mortality is predicted to have risen by 103% in men and 90% in women between 1985 and 2015. Hyperglycaemia is an independent risk factor for cardiovascular diseases. Therefore, we evaluated the effect of HbA1c values on clinical outcomes in diabetic and non-diabetic patients following acute coronary syndromes (ACS). METHODS The study was conducted in patients admitted with acute coronary syndromes in Department of Medicine in Chalmeda Anand Rao Institute of Medical Sciences from January 2017 to September 2018. Chi-square test was used wherever comparisons were needed between the two groups, or between two categories in the same group. A p value < 0.05 was considered significant. RESULTS SVD was seen in 100% of patients with HbA1c <5%. SVD and DVD were seen in 84.2 and 15.7% of patients with HbA1c 5.1-5.6%, respectively. SVD, DVD and TVD were seen in 57.65%, 34.6% and 7.6% of patients with HbA1c 5.7-6.4% respectively. SVD, DVD and TVD were seen in 50%, 15.3% and 34.6% of patients with HbA1c >6.5% respectively. In our study, RCA (42) was most frequently affected vessel followed by LAD (37) and LCX (20). CONCLUSIONS Higher HbA1c values were associated with more severe disease and more extensive involvement of coronary vessels in diabetics as well as pre-diabetics. RCA followed by LAD are common culprit vessel in diabetics.

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Aspects of Coronary Angiography in Diabetic Patients at the CHU Mother and Child Luxembourg in Bamako

Mamadou,

Massama,

Mariam

et al. 2024

CCR

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Introduction: Type 2 diabetes is on the increase in Africa as a result of the epidemiological transition. Cardiovascular complications, particularly ischemic complications, are common in diabetic patients. They are life-threatening. It is important to identify the angiographic appearance of the coronary arteries in diabetic patients in order to guide treatment. Objective: to identify the results of coronary angiography in diabetic patients. Patients and method: Descriptive, cross-sectional study with retrospective recruitment over a three-year period from September 2019 to August 2022. All diabetic patients who underwent coronary angiography at the CHU mother child Luxembourg in Bamako were included. Results: We enrolled 371 patients out of 985 during the study period, i.e. a hospital frequency rate of 37.66%. The mean age of the patients was 60.76 +/- 10.26 years, with extremes of 32 and 84 years. They were predominantly male, with a sex ratio of 1.45. The predominant functional signs were typical chest pain (39.4%), atypical chest pain (27.8%) and dyspnea (13.2%). The predominant risk factors were hypertension (74.7%), sedentary lifestyle (48.8%) and smoking (17.5%). The indications for coronary angiography were chronic coronary syndrome (55%) and acute coronary syndrome (45%). Coronary angiography was pathological in 78.4% of patients, with tritruncular lesions in 38% and bi-truncal lesions in 21%. Lesions were located on the common trunk in 5.4%, on the anterior interventricular in 59.8%, on the right coronary in 51.8% and on the circumflex in 47.4%. Conclusion: Ischemic heart disease is common in diabetic patients with tri- and bi-truncular lesions.

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Angiographic Severity of Coronary Artery Disease in Diabetic and Non-Diabetic Patients in a Tertiary Care Centre

Cited by 7 publications

References 11 publications

Diabetic CAD versus non diabetic CAD: a comparative study of clinical features, risk factors and angiographic profile

Diabetic CAD versus non diabetic CAD: a comparative study of clinical features, risk factors and angiographic profile

A Study on Glycaemic Status Impact in Acute Coronary Syndrome

Aspects of Coronary Angiography in Diabetic Patients at the CHU Mother and Child Luxembourg in Bamako

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