Angiographic Segment Size in Patients Referred for Coronary Intervention is Influenced by Constitutional, Anatomical, and Clinical Features

Lemos, Pedro A.; Ribeiro, Expedito E.; Perin, Marco Antônio; Kajita, Luiz J.; Magalhães, Marco A.; Falcão, João L. A. A.; Filho, Antônio Esteves; Gama, Mônica Elinor Alves; Horta, Pedro; Marchiori, Gilberto Guilherme Ajjar; Spadaro, André Gasparini; Martinez, Eulógio E.

doi:10.1007/s10554-006-9119-2

Cited by 15 publications

(8 citation statements)

References 28 publications

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“…Our estimate of OR of 0.86 per 1-SD (9.2 cm) increase in genetically determined height agrees with previous reports [ 21 , 22 ] which showed an estimated equivalent OR of 0.83–0.86. Shorter people have smaller caliber vessels which could cause symptomatic disease despite similar plaque burden [ 38 , 39 ]. Height also affects pulsatile arterial haemodynamics with increased augmentation of central systolic pressure in shorter people [ 40 ] that could influence disease risk in multiple vascular beds.…”

Section: Discussionmentioning

confidence: 99%

Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis

Lai

Nath

Hamby

et al. 2018

BMC Med

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BackgroundAdult height is associated with risk of several diseases, but the breadth of such associations and whether these associations are primary or due to confounding are unclear. We examined the association of adult height with 50 diseases spanning multiple body systems using both epidemiological and genetic approaches, the latter to identify un-confounded associations and possible underlying mechanisms.MethodsWe examined the associations for adult height (using logistic regression adjusted for potential confounders) and genetically determined height (using a two-sample Mendelian randomisation approach with height-associated genetic variants as instrumental variables) in 417,434 individuals of white ethnic background participating in the UK Biobank. We undertook pathway analysis of height-associated genes to identify biological processes that could link height and specific diseases.ResultsHeight was associated with 32 diseases and genetically determined height associated with 12 diseases. Of these, 11 diseases showed a concordant association in both analyses, with taller height associated with reduced risks of coronary artery disease (odds ratio per standard deviation (SD) increase in height ORepi = 0.80, 95% CI 0.78–0.81; OR per SD increase in genetically determined height ORgen = 0.86, 95% CI 0.82–0.90), hypertension (ORepi = 0.83, 95% CI 0.82–0.84; ORgen = 0.88, 95% CI 0.85–0.91), gastro-oesophageal reflux disease (ORepi = 0.85, 95% CI 0.84–0.86; ORgen = 0.94, 95% CI 0.92–0.97), diaphragmatic hernia (ORepi = 0.81, 95% CI 0.79–0.82; ORgen = 0.91, 95% CI 0.88–0.94), but increased risks of atrial fibrillation (ORepi = 1.42, 95% CI 1.38–1.45; ORgen = 1.33, 95% CI 1.26–1.40), venous thromboembolism (ORepi = 1.18, 95% CI 1.16–1.21; ORgen = 1.15, 95% CI 1.11–1.19), intervertebral disc disorder (ORepi = 1.15, 95% CI 1.13–1.18; ORgen = 1.14, 95% CI 1.09–1.20), hip fracture (ORepi = 1.19, 95% CI 1.12–1.26; ORgen = 1.27, 95% CI 1.17–1.39), vasculitis (ORepi = 1.15, 95% CI 1.11–1.19; ORgen = 1.20, 95% CI 1.14–1.28), cancer overall (ORepi = 1.09, 95% CI 1.08–1.11; ORgen = 1.06, 95% CI 1.04–1.08) and breast cancer (ORepi = 1.08, 95% CI 1.06–1.10; ORgen = 1.07, 95% CI 1.03–1.11). Pathway analysis showed multiple height-associated pathways associating with individual diseases.ConclusionsAdult height is associated with risk of a range of diseases. We confirmed previously reported height associations for coronary artery disease, atrial fibrillation, venous thromboembolism, intervertebral disc disorder, hip fracture and cancer and identified potential novel associations for gastro-oesophageal reflux disease, diaphragmatic hernia and vasculitis. Multiple biological mechanisms affecting height may affect the risks of these diseases.Electronic supplementary materialThe online version of this article (10.1186/s12916-018-1175-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis

Lai

Nath

Hamby

et al. 2018

BMC Med

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“…Additional biological mechanisms, which we were not able to explore, might also explain the observed effects on CHD. For example, shorter individuals have smaller vessel calibre, 23 which becomes more easily occluded leading to increased arterial occlusive events, 24 and have a higher risk of more advanced coronary atherosclerosis. 25 Shorter individuals also have faster heart rate and increased augmentation of the primary systolic pulse, indicating greater ventricular systolic work.…”

Section: Discussionmentioning

confidence: 99%

Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis

Nüesch

Dale

Palmer

et al. 2015

International Journal of Epidemiology

105

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Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis. Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D. Results: IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively],which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index (P < 0.001), triglycerides (P < 0.001), non high-density (non-HDL) cholesterol (P < 0.001), C-reactive protein (P = 0.042), and systolic blood pressure (P = 0.064) and higher levels of forced expiratory volume in 1 s and forced vital capacity (P < 0.001 for both). Conclusions: Taller individuals have a lower risk of CHD with potential explanations being that taller people have a better lung function and lower levels of body mass index, cholesterol and blood pressure.

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“…68 In recent studies using angiographic measurements, the coronary artery diameter was correlated with height and body weight. 69,70 It could be hypothesized that smaller coronary arteries may be occluded earlier in life under similar risk conditions.…”

Section: Discussionmentioning

confidence: 99%

Short stature is associated with coronary heart disease: a systematic review of the literature and a meta-analysis

Paajanen

Oksala

Kuukasjärvi

et al. 2010

European Heart Journal

273

150

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Angiographic Segment Size in Patients Referred for Coronary Intervention is Influenced by Constitutional, Anatomical, and Clinical Features

Cited by 15 publications

References 28 publications

Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis

Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis

Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis

Short stature is associated with coronary heart disease: a systematic review of the literature and a meta-analysis

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