Angiographic Risk Factors for Recurrence of Macular Edema Associated With Branch Retinal Vein Occlusion

Kogo, Takahiro; Muraoka, Yuki; Uji, Akihito; Ooto, Sotaro; Murakami, Tomoaki; Kadomoto, Shin; Iida-Miwa, Yuko; Miyake, Masahiro; Miyata, Manabu; Tsujikawa, Akitaka

doi:10.1097/iae.0000000000003026

Cited by 6 publications

(11 citation statements)

References 25 publications

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“…Supposing that deep capillaries drain interstitial fluid from the retina, ME more likely occurs in eyes without deep capillaries 21 . Moreover, capillary dilation and collateral vessel formation, which primarily occur in deep capillary plexus, are also observed in eyes with recurrent ME 14 , 15 . Our study did not assess these angiographic factors; nonetheless, we speculate that deep capillaries, which run between the INL and OPL 22 , possibly contribute to jagged border formation.…”

Section: Discussionmentioning

confidence: 97%

“…We speculated that the jagged border formation is associated with retinal deep capillaries. Recent studies have reported on the mechanisms of persistent ME and have investigated potential predictors of frequent anti-VEGF injection in eyes with BRVO 10 – 15 , 21 . Deep capillary loss detected by OCTA may be associated with persistent ME 12 , 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous fluorescein angiography (FA) studies demonstrated that the angiographic feature of incomplete capillary loss may be associated with recurrent ME in eyes with BRVO 10 , 11 . Although studies using optical coherence tomography angiography (OCTA) suggested potential predictors of anti-VEGF requirement over 1 year 12 – 15 , retinal hemorrhage and severe ME often cause difficulties in evaluating images at the initial visit. Sectional optical coherence tomography (OCT) images at the initial visit may allow for visual acuity (VA) prediction 16 – 19 ; however, prediction of ME recurrence is difficult at the initial visit 20 .…”

Section: Introductionmentioning

confidence: 99%

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Smooth borders between inner nuclear layer and outer plexiform layer predict fewer macular edema recurrences in branch retinal vein occlusion

Sasajima¹,

Tsuboi

Kiyosawa

et al. 2021

Sci Rep

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We hypothesized the smoothness of the border between the inner nuclear layer (INL) and outer plexiform layer (OPL) associates with the frequency of macular edema (ME) recurrences secondary to branch retinal vein occlusion (BRVO). Thirty-seven consecutive eyes with BRVO treated with anti-vascular endothelial growth factor (VEGF) injections at 1-year follow-up were included. We manually traced the border between the INL and OPL within the 1.5-mm vertical line from the fovea on optical coherence tomography (OCT) images at the initial visit. The jagged ratio (JR), the border length divided by the spline curve length, was calculated. We performed univariate and multivariate regression analyses, including JR, patient characteristics, number of cystoid spaces in the INL, INL area, and outer retina area. Multivariate regression analysis showed JR significantly correlates with the total number of anti-VEGF injections (P < 0.0001). Moreover, the mean JR was significantly lower in the nine eyes receiving two or fewer injections than in the 28 eyes receiving three or more injections (1.02 ± 0.01 vs. 1.13 ± 0.06, P < 0.0001). A smooth border between the INL and the OPL on OCT images at the initial visit may be a biomarker for fewer ME recurrences in eyes with BRVO.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Smooth borders between inner nuclear layer and outer plexiform layer predict fewer macular edema recurrences in branch retinal vein occlusion

Sasajima¹,

Tsuboi

Kiyosawa

et al. 2021

Sci Rep

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“…RVO is associated with many risk factors for RVO, including age, the crossing of retinal arteries and veins (AV), high intraocular pressure, short eye axis, retinal vascular wall sclerosis, dyslipidemia, hyperglycemia, hypertension, smoking, etc. Its etiology is complex and the pathogenesis is not fully understood (3)(4)(5)(6). Currently, other than symptomatic treatments for RVO there is no fundamentally effective therapy available.…”

Section: Introductionmentioning

confidence: 99%

Chorioretinal venous anastomosis for non-ischemic retinal vein occlusion

Wang¹,

Wang²,

Wang³

et al. 2022

Front. Ophthalmol.

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Retinal vein occlusion (RVO) refers to the occlusion of the central retinal vein or primary and secondary branches caused by multiple factors. Clinical treatments for it include intravitreal or systemic vasodilator application, local usage of steroids and NSAID (non-steroidal anti-inflammatory drugs), thrombolysis, hemodilution, retinal laser photocoagulation, vitrectomy with vascular sheath incision, chorioretinal venous anastomosis (CRVA), and so on. At present, most treatments are aimed at RVO complications, while chorioretinal vein anastomosis can fundamentally reflux retinal vein blood through the choroid by venous vascular remodeling. Reports on the treatment of retinal vein occlusion by chorioretinal anastomosis are numerous in various countries. As a treatment means, CRVA can drain the venous blood, skipping the thrombosis spot, thus partially relieving anatomical vascular occlusion to achieve a therapeutic purpose. In this study, CRVA is evaluated from the aspects of indications, implementation process, postoperative effect evaluation, complications, and combination with anti-VEGF treatment. Based on the development of laser technology and vitrectomy, we hope to further review this treatment and provide a new reference for the clinical treatment of RVO.

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“…Optical coherence tomography angiography visualizes retinal blood flow by extracting decorrelation signals that change among multiple OCT-B scans acquired at the same location; this facilitates detection of retinal nonperfusion, microaneurysms, and collateral vessels in eyes with RVO. [9][10][11][12][13] By contrast, it has also been reported that OCTA does not detect all of the lesions delineated by FA 14 ; this may be related to the association between the blood flow velocity and interscan time (IST) of OCTA. [15][16][17] If the blood flow velocity is below the detection threshold of the IST, it theoretically cannot be visualized by OCTA.…”

mentioning

confidence: 99%

Macular Blood Flow Changes in Branch Retinal Vein Occlusion Examined by Optical Coherence Tomography Angiography Variable Interscan Time Analysis

Nishigori

Muraoka

Ishikura

et al. 2022

Retina

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To examine the relationship between changes in retinal blood flow and the recurrence of macular edema in eyes with branch retinal vein occlusion.Methods: This observational study included 32 eyes in 32 patients (18 men and 14 women) with branch retinal vein occlusion who visited the Department of Ophthalmology at Kyoto University Hospital (February 2021-November 2021). At the time of inclusion in the study, each patient underwent optical coherence tomography angiography on a macular area measuring 4 • 4 mm 2 . For variable interscan time analysis, different interscan times were set at 7.6 (IST 7.6 ) and 20.6 ms (IST 20.6 ) for the optical coherence tomography angiography. The parafoveal vessel densities were measured sectorally at IST 7.6 and IST 20.6 , and their relationship with the longitudinal changes evident in the retinal thicknesses during the variable interscan time analysis examination and 2 months later was evaluated.Results: The parafoveal vessel densities in the affected sector was significantly greater at IST 20.6 than at IST 7.6 (P = 0.011). At 2 months after the variable interscan time analysis examination, 6 patients (19%) showed recurrence of macular edema involving the fovea. The difference in the parafoveal vessel densities (IST 20.6 2 IST 7.6 ) in the affected sector was significantly associated with longitudinal retinal thickening in the corresponding parafovea (P = 0.020) and fovea (P = 0.014). Conclusion:In eyes with branch retinal vein occlusion, optical coherence tomography angiography variable interscan time analysis facilitated the detection of retinal blood flow changes that might be predictive for the recurrence of macular edema.

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Angiographic Risk Factors for Recurrence of Macular Edema Associated With Branch Retinal Vein Occlusion

Cited by 6 publications

References 25 publications

Smooth borders between inner nuclear layer and outer plexiform layer predict fewer macular edema recurrences in branch retinal vein occlusion

Smooth borders between inner nuclear layer and outer plexiform layer predict fewer macular edema recurrences in branch retinal vein occlusion

Chorioretinal venous anastomosis for non-ischemic retinal vein occlusion

Macular Blood Flow Changes in Branch Retinal Vein Occlusion Examined by Optical Coherence Tomography Angiography Variable Interscan Time Analysis

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