Angiographic frequency of saccular intracranial aneurysms in patients with spontaneous cervical artery dissection

Schievink, Wouter I.; Mokri, Bahram; Piepgras, David G.

doi:10.3171/jns.1992.76.1.0062

Cited by 58 publications

(24 citation statements)

References 39 publications

(6 reference statements)

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“…40 Patients with CAD also often present concomitant arterial anomalies such as fibromuscular dysplasia, 15 aortic root dilation, 41 hyperdistensibility of the arterial wall, 42 or endothelial dysfunction, 43 and an association with intracranial aneurysms 44 and temporal artery histological changes 45 has been suggested by some authors.…”

Section: Genetics Of Sporadic Cad How Important Are Genetic Factors Imentioning

confidence: 99%

The Genetics of Cervical Artery Dissection

Debette

Markus

2009

Stroke

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Background and Purpose-The pathophysiology of cervical artery dissections (CAD), a major cause of ischemic stroke in young adults, is poorly understood. Several arguments suggest a genetic predisposition. Methods-We systematically reviewed all published data on genetic risk factors for CAD and performed a meta-analysis of association studies with the MTHFR C677T polymorphism. Results-Rarely, CAD is associated with a known monogenic connective tissue disease, mainly vascular Ehlers-Danlos syndrome. However, in the large majority of CAD cases, there is no evidence for a known monogenic disease. Several arguments, including the association of CAD with dermal connective tissue abnormalities that are inherited, suggest that genetic factors also play a role in "sporadic" CAD as part of a multifactorial predisposition. We identified 15 genetic association studies: 10 were negative and 5 reported associations of 3 genetic variants in 3 different candidate genes. Two studies reported associations with polymorphisms in ICAM-1 and COL3A1, but neither has been replicated. Three studies reported an association with the MTHFR 677TT genotype, but 3 other studies did not replicate this. A meta-analysis of these data identified an overall significant association of the MTHFR 677TT genotype with CAD (OR, 1.67; 95% CI, 1.21 to 2.31). We also identified 9 studies screening candidate genes for mutations and 4 linkage studies, yielding mostly negative results. Conclusions-Although several interesting hypotheses were generated, the majority of genetic studies in CAD have been negative until now, but they were markedly underpowered. Progress in unraveling the genetics of CAD will require the collection of DNA samples from large multicenter series. (Stroke. 2009;40:e459-e466.)

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Section: Genetics Of Sporadic Cad How Important Are Genetic Factors Imentioning

confidence: 99%

The Genetics of Cervical Artery Dissection

Debette

Markus

2009

Stroke

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“…Furthermore, pseudoaneurysms do not increase the risk for embolic complication [32]. However, a higher incidence of intracranial aneurysm associated with the occurrence of CAD is described and exclusion of an intracranial aneurysm could be an indication for DSA [33]. Platelet antiaggregation as secondary prophylaxis is usually prescribed as subsequent treatment.…”

Section: Treatment and Prognosismentioning

confidence: 99%

Cervical Artery Dissection: Update and New Results of Research of the Pathogenesis

Brandt¹

2000

Cerebrovasc Dis

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“…56 The pathogenesis of intracranial aneurysms and cervical artery dissection is complex and incompletely understood. The occurrence of both intracranial aneurysms and dissection of the cervical arteries in the same families provides support to the importance of a common underlying primary arteriopathy in the development of these vascular disorders.…”

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confidence: 99%

Familial association of intracranial aneurysms and cervical artery dissections.

Schievink

Mokri

Michels

et al. 1991

Stroke

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Background and Purpose:The familial occurrence of intracranial aneurysms and cervical artery dissections has been described in different families and supports the hypothesis that a primary arteriopathy may play a role in the pathogenesis of these disorders. Although the basis for this arteriopathy is generally not believed to be similar among cases of intracranial aneurysms and cervical artery dissections, several similarities exist in the epidemiology of these disorders and a common underlying arterial abnormality may be suspected. Summary of Reports:The medical records of all 175 patients with spontaneous dissections of the cervical arteries who were seen at the Mayo Clinic between 1970 and 1989 were reviewed to identify families in which intracranial aneurysms and cervical dissections coexisted. Three families were identified in which intracranial aneurysms and cervical artery dissections were observed among siblings. These families are described in detail.Conclusions: The familial occurrence of intracranial aneurysms and cervical artery dissections within the same families provides support to the importance of a common underlying arteriopathy in the pathogenesis of both these disorders. The underlying vascular defect may, at least in some cases, be inherited. (Stroke 1991;22:1426-1430)

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Angiographic frequency of saccular intracranial aneurysms in patients with spontaneous cervical artery dissection

Cited by 58 publications

References 39 publications

The Genetics of Cervical Artery Dissection

The Genetics of Cervical Artery Dissection

Cervical Artery Dissection: Update and New Results of Research of the Pathogenesis

Familial association of intracranial aneurysms and cervical artery dissections.

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