Angiographic factors leading to hemorrhage in AVMs: A systematic review and meta-analysis

Koester, Stefan W.; Batista, Sávio; Bertani, Raphael; Yengo‐Kahn, Aaron M.; Roth, Steven; Chitale, Rohan; Dewan, Michael

doi:10.1007/s10143-023-01971-z

Cited by 5 publications

(2 citation statements)

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“…MRI is usually more capable of characterizing these lesions than CT or angiography. Patients with vascular malformations with focal neurological symptoms and no bleeding are best evaluated through MRI [13]. It is easy to prove patent vascular malformations, manifested as flow void and other flow-related phenomena [14].…”

Section: Cerebral and Spinal Vascular Diseasesmentioning

confidence: 99%

Introductory Chapter: Advances in Neuroimaging

2024

Frontiers in Neuroimaging

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FMRI of the spinal cord utilizes various methods and stimulation schemes to gain a deeper understanding of the healthy human spinal cord, laying the foundation for its clinical research and practical application [19]. New fMRI techniques and new knowledge about healthy human spinal cord have been established. Spinal cord fMRI advancement and research will further enhance our understanding of various spinal cord diseases and provide the foundation for evaluating existing and developing new treatment plans [20]. Driven by these developments, studying pathology and injury status within the spinal cord, such as fibromyalgia, multiple sclerosis, spinal cord injury, and cervical spondylotic myelopathy, have provided in-depth insights into the temporal processes of spinal cord injury and changes caused by injury, has become the next important direction in spinal fMRI. TinnitusAlthough tinnitus may originate from damage to the peripheral auditory apparatus, its perceptual and painful symptoms are the result of changes in auditory, sensory, and limbic neural networks. Understanding these complex changes can promote the development of targeted therapy. When the diagnosis of Meniere's disease is unclear, a new MRI technique that can describe the maze in detail may be useful. The advancement of CT, MRI, and DSA has made diagnosis of cerebral aneurysmas, arteriovenous malformations, and dural arteriovenous fistulas possible [15,21]. ConclusionsIn the past few decades, neuroimaging has evolved from anatomical imaging to multimodal comprehensive anatomical and functional imaging. The minimally invasive treatment possibilities of interventional neuroradiology, image-guided laser ablation, and MRI-guided high-intensity-focused ultrasound will be used for the treatment of brain and spinal pathology.

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Section: Cerebral and Spinal Vascular Diseasesmentioning

confidence: 99%

Introductory Chapter: Advances in Neuroimaging

2024

Frontiers in Neuroimaging

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“…Intracranial aneurysm (IA) is a localized, aneurysmal dilatation of an intracranial artery, and it is a serious cerebrovascular disease with high morbidity and mortality (Sheinberg et al, 2019;Koester et al, 2023;Reddy and Masoud, 2023). Effective methods to stabilize and prevent IA rupture are currently lacking, and conservative treatment is most commonly employed for IA patients.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiome and metabolome in aneurysm rat with hypertension after ginsenoside Rb1 treatment

Zeng,

Wang,

et al. 2023

Front. Pharmacol.

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Introduction: Hypertension is a well-known risk factor for aneurysms, as high blood pressure can worsen the development and rupture of aneurysms. Ginsenoside, derived from ginseng and widely used in traditional herbal medicine, is believed to have antihypertensive properties. Recent research has also shown a connection between gut microbiota and various diseases, including hypertension. However, the relationship between ginsenosides, gut microbiota, blood pressure, and intracranial aneurysms needs further exploration.Methods: In this study, a rat model was used to investigate the effects of ginsenosides on both blood pressure and intracranial arteries. Comparative analysis was conducted, and 16S rRNA sequencing was employed to identify marker genera within the gut microbiota. Metabolites were also analyzed to uncover potential mediators of blood pressure regulation.Results and Discussion: The results of this study revealed that ginsenosides, particularly ginsenoside Rb1, demonstrated positive effects in reducing both blood pressure and the development of intracranial aneurysms in rats. Furthermore, the analysis of gut microbiota showed that certain genera, including Clostridium, Roseburia, Ruminococcus, and Treponema, were significantly influenced by ginsenoside treatment. Several metabolites, such as behenic acid, N-Acetylserotonin, Prostaglandin F2a, and Vitamin D2, were also detected, all of which play a role in regulating blood pressure. These findings provide valuable insights into the potential benefits of ginsenosides in hypertension and atheroma development. Furthermore, they suggest a possible link between ginsenosides, gut microbiota, and blood pressure regulation. Further research is needed to fully understand the mechanisms underlying these effects and to determine the clinical implications for treating hypertension and reducing the risk of aneurysm development.

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