Angiogenin regulates mitochondrial stress and function via tRNA-derived fragments generation and impacting tRNA modifications
Shadi Al-Mesitef,
Keita Tominaga,
Abdulrahman Mousa
et al.
Abstract:Mitochondrial stress and dysfunction play an important role in many diseases, such as cancer, diabetes, and neurodegenerative diseases. We previously observed that mitochondrial electron transport chain (ETC) inhibition can induce tRNA cleavage and tsRNAs (tRNA-derived small non-coding RNAs) generation. However, whether this process is mediated via Angiogenin (ANG), the canonical enzyme responsible for tRNA cleavage, and whether it has a role in regulating the mitochondrial stress response remains to be unders… Show more
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