Angiogenic potential of mesenchymal stem cells derived from patients with diabetes seeded on decellularized micro fragments

Assis, Assaf; Gellman, Yechiel N.; Cahn, Avivit; Haze, Amir; Camargo, Sandra; Mitrani, Eduardo

doi:10.1016/j.jdiacomp.2021.108001

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…They then transplanted the acellular micro-fragment from the bone marrow of an elderly diabetic patient suffering from lower extremity arterial disease and DFU. They found that the MSCs expressed and secreted angiogenic factors similar to those extracted from healthy individuals ( 153 ). This provides a good idea for researching and developing stem cells and scaffolds.…”

Section: Mscs and Stem Cellsmentioning

confidence: 99%

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

Liu

et al. 2023

Front. Endocrinol.

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Diabetes has become a global public health problem. Diabetic foot is one of the most severe complications of diabetes, which often places a heavy economic burden on patients and seriously affects their quality of life. The current conventional treatment for the diabetic foot can only relieve the symptoms or delay the progression of the disease but cannot repair damaged blood vessels and nerves. An increasing number of studies have shown that mesenchymal stem cells (MSCs) can promote angiogenesis and re-epithelialization, participate in immune regulation, reduce inflammation, and finally repair diabetic foot ulcer (DFU), rendering it an effective means of treating diabetic foot disease. Currently, stem cells used in the treatment of diabetic foot are divided into two categories: autologous and allogeneic. They are mainly derived from the bone marrow, umbilical cord, adipose tissue, and placenta. MSCs from different sources have similar characteristics and subtle differences. Mastering their features to better select and use MSCs is the premise of improving the therapeutic effect of DFU. This article reviews the types and characteristics of MSCs and their molecular mechanisms and functions in treating DFU to provide innovative ideas for using MSCs to treat diabetic foot and promote wound healing.

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Section: Mscs and Stem Cellsmentioning

confidence: 99%

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

Liu

et al. 2023

Front. Endocrinol.

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“…Decreased viability of stem cells due to late glycosylation end products in a hyperglycemic environment diminishes the efficacy of stem cells in enhancing wound healing in DFUs [ 65 ]. However, a study by Assis et al [ 66 ] reported that the MSCs from diabetic patients have the same potential for angiogenesis if they are seeded on decellularized micro fragments. The MSCs were isolated from the bone marrow of distal tibial or femoral shafts from the amputated limb.…”

Section: Limitations and Future Perspectivesmentioning

confidence: 99%

Stem Cells and Angiogenesis: Implications and Limitations in Enhancing Chronic Diabetic Foot Ulcer Healing

Rai

Moellmer

Agrawal

2022

Cells

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Nonhealing diabetic foot ulcers (DFUs) are a continuing clinical issue despite the improved treatment with wound debridement, off-loading the ulcer, medication, wound dressings, and preventing infection by keeping the ulcer clean. Wound healing is associated with granulation tissue formation and angiogenesis favoring the wound to enter the resolution phase of healing followed by healing. However, chronic inflammation and reduced angiogenesis in a hyperglycemic environment impair the normal healing cascade and result in chronically non-healing diabetic foot ulcers. Promoting angiogenesis is associated with enhanced wound healing and using vascular endothelial growth factors has been proven beneficial to promote neo-angiogenesis. However, still, nonhealing DFUs persist with increased risks of amputation. Regenerative medicine is an evolving branch applicable in wound healing with the use of stem cells to promote angiogenesis. Various studies have reported promising results, but the associated limitations need in-depth research. This article focuses on summarizing and critically reviewing the published literature since 2021 on the use of stem cells to promote angiogenesis and enhance wound healing in chronic non-healing DFUs.

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Angiogenic potential of mesenchymal stem cells derived from patients with diabetes seeded on decellularized micro fragments

Cited by 2 publications

References 19 publications

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

Stem Cells and Angiogenesis: Implications and Limitations in Enhancing Chronic Diabetic Foot Ulcer Healing

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