Angiogenic potential of ductal carcinoma <i>in situ</i> (DCIS) of human breast

Vogl, Georgia; Dietze, Otto; Hauser‐Kronberger, Cornelia

doi:10.1111/j.1365-2559.2005.02299.x

Cited by 17 publications

(17 citation statements)

References 22 publications

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“…The degree of angiogenesis was variable and strongly related to the degree of vascular endothelial growth factor (VEGF) expression. High grade DCIS was more often associated with a strong VEGF expression than low grade lesions, which was also observed by Vogl et al [29]. However, these differences in VEGF expression between low grade and high grade lesions were not statistically significant.…”

Section: Discussionsupporting

confidence: 74%

“…The process of angiogenesis is stimulated by growth factors such as vascular endothelial growth factor (VEGF) and plateletderived endothelial growth factor/thymidine phosphorylase (PD-ECGF/TD) released into the stroma by tumor and immune cells [29,30]. Vogl et al [29] found PD-ECGF/TP to be present in all cases of DCIS, without a significant correlation with the DCIS subtype. In the study of Guidi et al [30], in 84% of the cases of DCIS microvessel density was more prominent than in benign tissue.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of false-negative cases of breast MR imaging in women with a familial or genetic predisposition

Obdeijn

Loo

Rijnsburger

et al. 2009

Breast Cancer Res Treat

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In order to assess the characteristics of malignant breast lesions those were not detected during screening by MR imaging. In the Dutch MRI screening study (MRISC), a non-randomized prospective multicenter study, women with high familial risk or a genetic predisposition for breast cancer were screened once a year by mammography and MRI and every 6 months with a clinical breast examination (CBE). The false-negative MR examinations were subject of this study and were retrospectively reviewed by two experienced radiologists. From November 1999 until March 2006, 2,157 women were eligible for study analyses. Ninety-seven malignant breast tumors were detected, including 19 DCIS (20%). In 22 patients with a malignant lesion, the MRI was assessed as BI-RADS 1 or 2. One patient was excluded because the examinations were not available for review. Forty-three percent (9/21) of the false-negative MR cases concerned pure ductal carcinoma in situ (DCIS) or DCIS with invasive foci, in eight of them no enhancement was seen at the review. In six patients the features of malignancy were missed or misinterpreted. Small lesion size (n = 3), extensive diffuse contrast enhancement of the breast parenchyma (n = 2), and a technically inadequate examination (n = 1) were other causes of the missed diagnosis. A major part of the false-negative MR diagnoses concerned non-enhancing DCIS, underlining the necessity of screening not only with MRI but also with mammography. Improvement of MRI scanning protocols may increase the detection rate of DCIS. The missed and misinterpreted cases are reflecting the learning curve of a multicenter study.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Assessment of false-negative cases of breast MR imaging in women with a familial or genetic predisposition

Obdeijn

Loo

Rijnsburger

et al. 2009

Breast Cancer Res Treat

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“…The central necrotic areas are interpreted as an indication that the neoplastic cells are growing faster and that there is therefore a higher risk of progression to invasive carcinoma. 41,42 The comedo appearance was mentioned in the WHO classification as a feature occasionally detectable in CMC in situ. 27 Those comedocarcinomas identified in the present study were not in situ lesions.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study of Those Histopathologic Parameters Predictive of Invasion of the Lymphatic System by Canine Mammary Carcinomas

et al. 2011

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The aim of the present study was to determine which histopathologic parameters of primary canine mammary carcinomas (CMCs) could predict metastatic spread via the lymphatic system. A modification of the World Health Organization classification was applied to 245 CMCs. In addition to tumor subtype, neoplastic infiltration of the surrounding mammary stroma, vasculogenic mimicry, and micropapillary pattern were evaluated, and 2 histologic grading systems were used for each sample. A statistical analysis was undertaken to determine the relationship between these histopathologic parameters and the detection of lymphatic vessels invasion (LVI) and regional lymph node metastases (RLM). To compare the predictive value for lymphatic spread of the 2 histologic grading systems, the Akaike information criterion was measured. The classification into tumor subtypes was significant (P < .01) in predicting the risk of LVI and RLM. Peripheral infiltration, vasculogenic mimicry, and micropapillary pattern were found in 170 of 245 (69.4%), 32 of 245 (13.1%), and 54 of 245 (22.0%) CMCs. The presence of peripheral infiltration was significantly associated (P < .001) with both LVI and RLM, and a similar relation (P < .05) was found for the micropapillary pattern. Vasculogenic mimicry was not predictive of invasion of the lymphatic system. Both histologic grading systems were significant predictors (P < .001) of the risk of LVI and RLM. The grading system that included a more rigorous evaluation of the neoplastic mitotic activity had the lower Akaike information criterion values, thus indicating a better predictive ability. The study confirms the significant prognostic role for the modified World Health Organization classification of CMCs and the prognostic value of additional histopathologic parameters.

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“…It involves the process of endothelial cell activation, degradation of the basement membrane and extracellular matrix, with migration and proliferation of endothelial cells. It has been associated with overexpression of estrogen and progesterone receptors (Vamesu, 2008), progression from ductal carcinoma in-situ (Vogl et al, 2005), metastasis (Weidner (Karelia et al, 1997;JanShow et al, 1998;Nazan et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Expression of Bax and Bcl-2 in Tumour Cells and Blood Vessels of Breast Cancer and their Association with Angiogenesis and Hormonal Receptors

Jaafar

Abdullah²,

Murtey³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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A total of 96 cases of invasive breast ductal carcinoma were examined for immunohistochemical expression of Bax and Bcl-2 in the epithelial tumor cells and endothelial cells of the blood vessels. We also investigated the association between both proteins in the epithelium in relation to tumor characteristics such as tumor size, grade, lymph node involvement, microvessel density (MVD), hormonal receptors expression and c-erbB-2 overexpression. Bax expression showed a significant association between tumor and endothelial cells (p<0.001) while Bcl-2 expression in tumor cells was inversely associated with that in the endothelial cells (p<0.001). Expression of Bcl-2 in tumor cells was strongly associated with expression of estrogen and progesterone receptors (p=0.003 and p=0.004, respectively). In addition, intratumoral MVD was significantly higher than peritumoral MVD (p<0.001) but not associated with Bax or Bcl-2 expression and other tumor characteristics. We concluded that the number of endothelial cells undergoing apoptosis was in direct linkage with the number of apoptotic tumor cells. Anti-apoptotic activity of the surviving tumor cells appears to propagate cancer progression and this was influenced by the hormonal status of the cells. Tumor angiogenesis was especially promoted in the intratumoral region and angiogenesis was independent of anti-apoptotic activity.

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Angiogenic potential of ductal carcinoma in situ (DCIS) of human breast

Cited by 17 publications

References 22 publications

Assessment of false-negative cases of breast MR imaging in women with a familial or genetic predisposition

Assessment of false-negative cases of breast MR imaging in women with a familial or genetic predisposition

A Retrospective Study of Those Histopathologic Parameters Predictive of Invasion of the Lymphatic System by Canine Mammary Carcinomas

Expression of Bax and Bcl-2 in Tumour Cells and Blood Vessels of Breast Cancer and their Association with Angiogenesis and Hormonal Receptors

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