Angiogenic factor screening in women with mild preeclampsia – New and significant proteins in plasma

Charkiewicz, Karol; Jasińska, Elwira; Gościk, Joanna; Koc-Żórawska, Ewa; Żórawski, Marcin; Kuć, Paweł; Raba, Grzegorz; Kluz, Tomasz; Kalinka, Jarosław; Sakowicz, Agata; Laudański, Piotr

doi:10.1016/j.cyto.2017.10.020

Cited by 31 publications

(21 citation statements)

References 49 publications

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“…Since FS is a pro-angiogenic molecule, the downregulation of FS in PE is plausible , in view of the decreased angiogenesis (Turcotte et al, 2017). Additionally, our findings are supported by Charkiewicz et al (2018) who reported that pro-angiogenic factors (VEGF and PIGF) are downregulated, with a concurrent significant decline in FS expression in women with PE.…”

Section: Synthesissupporting

confidence: 88%

The role of follistatin and granulocyte-colony stimulating factor in HIV-associated pre-eclampsia

Mdlalose

Moodley

Naicker

2020

Pregnancy Hypertension

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I, Siphesihle Mdlalose declare that: i.The research reported in this dissertation, except where otherwise indicated is my original work.ii. This dissertation has not been submitted for any degree or examination at any other university.iii. This dissertation does not contain other person's data, pictures, graphs or other information, unless specifically acknowledged as being sourced from other persons. iv. This dissertation does not contain other persons writing, unless specifically acknowledged as being sourced from other researchers. Where other sources have been quoted, then: a. Their words have been rewritten but the general information attributed by them has been referenced. b. Where their exact words have been used their writing has been placed inside quotation marks and referenced. v. Where I have reproduced a publication of which I am the author, co-author, I have indicated in detail which part of the publication was actually written by myself alone and have fully referenced such publications.vi. This dissertation does not contain text, graphics, or tables copied and pasted from the internet, unless specifically acknowledged and the source being detailed in the dissertation and the reference sections.

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Section: Synthesissupporting

confidence: 88%

The role of follistatin and granulocyte-colony stimulating factor in HIV-associated pre-eclampsia

Mdlalose

Moodley

Naicker

2020

Pregnancy Hypertension

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“…The mRNA LIF was selected through the jak-stat signaling pathway and ceRNA network in our research. Charkiewicz et al reported a statistically significant increase in the concentration of LIF in the plasma of women with PE [13]. The study launched by Zheng et al indicated a role for LIF in promoting trophoblast migration and invasion through uPAR and suggested it might be associated with the etiology of PE [36].…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported to negatively regulate tumor-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers [11], and also LIF withdrawal is reported to activate mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway [12]. Importantly, some studies found that LIF was high expression in preeclamptic patients [13–15]. One study reported that LIF could regulate chondroitin sulfate proteoglycan 4 (CSPG4) expression to impact human trophoblast function [16].…”

Section: Introductionmentioning

confidence: 99%

Identification of Key circRNAs/lncRNAs/miRNAs/mRNAs and Pathways in Preeclampsia Using Bioinformatics Analysis

et al. 2019

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BackgroundThis study aimed to identify significantly altered circRNAs/lncRNAs/miRNAs/mRNAs pathways in preeclampsia (PE), investigate their target relationships, and determine their biological functions.Material/MethodsBase on RNA-seq technique and the GEO database, expression profiles of circRNAs/lncRNAs/miRNAs/mRNAs related to PE were obtained. Differentially expressed RNAs were determined using the Limma package in R. Gene set enrichment analysis (GSEA) was performed using GSEA software (v. 3.0) and illustrated by ClusterProfiler and ggplot2 package in R. DAVID database (v. 6.8) was implemented to analyze functional categories and the association between genes and the corresponding Gene Ontology (GO) classification. The R visualization package GOPlot was used to get a better visualization of the relationships between genes and the selected functional categories. CeRNA networks which visualized the correlations between circRNA/lncRNA-miRNA-mRNA were constructed using Cytoscape software (v. 3.6.0). Targetscan and miRanda database were used to predict target relationships between circRNA/lncRNA-miRNA-mRNA. QRT-PCR and luciferase reporter assay were used to verify the expression and target relationship of has_circ_0088196/LINC01492/miR-100-5p/LIF (leukemia inhibitory factor).ResultsThe jak-stat signaling pathway was activated and miR-100-5p was downregulated in PE compared with normal tissues both in collected placental tissue samples and GEO database. Upregulated LIF, LINC01492, and hsa_circ_0088196 were negatively correlated with miR-100-5p expression and had a targeted relationship with miR-100-5p.ConclusionsmiR-100-5p may suppress PE development, while LIF, LINC01492, and hsa_circ_0088196 may promote it though inhibiting miR-100-5p. The jak-stat signaling pathway was activated and involved in PE progression.

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“…Different studies have found that the mean PLGF level in preeclampsia is following 125 pg/ml at gestational age 20-37 weeks [8]: 95 pg/ml at midtrimester gestational age [9]; 38.7 pg/ml at 32-37 weeks gestation [10]; 54 pg/ml at 20-34 weeks gestation [11]; 83.75 pg/ml at 20-30 weeks gestation [12]; 239.75 pg/ml at 25-40 weeks’ gestation [13].…”

Section: Discussionmentioning

confidence: 99%

The Role of Placental Growth Factor, Soluble Endoglin, and Uterine Artery Diastolic Notch to Predict the Early Onset of Preeclampsia

Lubis¹,

Hariman²,

Lumbanraja³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Reducing maternal mortality is one of the targets in the Millennium Development Goals (MDGs). In a systematic review, 4.6 per cent (95% CI 2.7-8.2) of pregnancies were complicated by preeclampsia worldwide. Preeclampsia occurs in around 10% of pregnancies in the world whereas developing countries contribute more than developed countries. In developing countries, there are 13 cases of preeclampsia in every 1,000 births, whereas in developed countries only 2-3 cases of preeclampsia are found in every 10,000 deliveries. Variations in prevalence among countries reflect, at least in part, differences in the distribution of maternal age and the proportion of nulliparous pregnant women in the population. AIM: We aimed to investigate the role of placental growth factor, soluble endoglin, and uterine artery diastolic notch to predict the early onset of preeclampsia. METHODS: This study used an analytical study with a nested case-control design. The study was conducted at Bunda Thamrin Hospital, Tanjung Mulia Mitra Medika Hospital, Sundari Hospital and a private clinic, from March to November 2018 with a total sample of 70 research subjects. RESULTS: Uterine artery diastolic notch was not found in 50% of subjects. A total of 27 subjects (38.6%) had a unilateral diastolic notch, and 8 subjects (11.4%) had a bilateral diastolic notch. Cut-off point PIGF levels was 441 pg/ml, and Area Under Curve (AUC) 82.5% (95% CI 61.5%-100%), with sensitivity 80% and specificity 87.7%. The levels sEng in this study could not predict the incidence of early-onset preeclampsia (p = 0.113). Combined PlGF and pulsatile index of uterine arteries may predict early onset preeclampsia with sensitivity 40% and specificity 90.77%. From these results, pregnant women o 22-24 weeks of pregnancy, the levels of PlGF and the uterine artery pulsatility index can be a predictor of early-onset preeclampsia. Examination of PlGF levels alone is sufficient as a predictor of early-onset preeclampsia. CONCLUSION: From these results, it can be concluded that in pregnant women of 22-24 weeks, the diastolic notches in uterine arteries cannot predict the incidence of early-onset preeclampsia. PlGF levels and pulsatile index of uterine arteries can be used as predictors of early-onset preeclampsia although examination of PlGF levels alone is sufficient as a predictor of early-onset preeclampsia.

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Angiogenic factor screening in women with mild preeclampsia – New and significant proteins in plasma

Cited by 31 publications

References 49 publications

The role of follistatin and granulocyte-colony stimulating factor in HIV-associated pre-eclampsia

The role of follistatin and granulocyte-colony stimulating factor in HIV-associated pre-eclampsia

Identification of Key circRNAs/lncRNAs/miRNAs/mRNAs and Pathways in Preeclampsia Using Bioinformatics Analysis

The Role of Placental Growth Factor, Soluble Endoglin, and Uterine Artery Diastolic Notch to Predict the Early Onset of Preeclampsia

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