Angiogenic Activity of Human Adipose-Derived Mesenchymal Stem Cells Under Simulated Microgravity

Ratushnyy, A. Yu.; Ездакова, М. И.; Yakubets, D.A.; Буравкова, Л. Б.

doi:10.1089/scd.2017.0262

Cited by 27 publications

(19 citation statements)

References 29 publications

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“…MSCs secrete VEGF, FGF, HGF, placental growth factor (PGF), monocyte chemotactic protein 1 (MCP-1), stromal cell-derived factor 1 (SDF-1), and angiopoietin-1 (Ang-1) that are critical for vascularization [178][179][180][181][182][183]. Several studies have reported the potential of increasing capillaries and newly formed vessels following MSC administration both in vitro and in vivo [184][185][186].…”

Section: Angiogenic Factorsmentioning

confidence: 99%

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

Fan

Zhang

et al. 2020

Cell. Mol. Life Sci.

372

282

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Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of various diseases. The therapeutic potential of MSCs is attributed to complex cellular and molecular mechanisms of action including differentiation into multiple cell lineages and regulation of immune responses via immunomodulation. The plasticity of MSCs in immunomodulation allow these cells to exert different immune effects depending on different diseases. Understanding the biology of MSCs and their role in treatment is critical to determine their potential for various therapeutic applications and for the development of MSC-based regenerative medicine. This review summarizes the recent progress of particular mechanisms underlying the tissue regenerative properties and immunomodulatory effects of MSCs. We focused on discussing the functional roles of paracrine activities, direct cell-cell contact, mitochondrial transfer, and extracellular vesicles related to MSC-mediated effects on immune cell responses, cell survival, and regeneration. This will provide an overview of the current research on the rapid development of MSC-based therapies. Keywords Regenerative potential • Integration of MSCs • Immunomodulation • Soluble factors • Cell-cell contact • Mitochondrial transfer • Extracellular vesicles Abbreviations AHR Airway hyper-responsiveness Alix ALG-2-interacting protein X Ang-1 Angiopoietin-1 ASCs Adipose-derived stem cells BAX BCL-2-associated X protein BCL-2 B-cell lymphoma 2 CASP3 Caspase 3 CX43 Connexin 43 CXCR4 Chemokine receptor type 4 DC Dendritic cell Cellular and Molecular Life Sciences

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Section: Angiogenic Factorsmentioning

confidence: 99%

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

Fan

Zhang

et al. 2020

Cell. Mol. Life Sci.

372

282

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“…It is expected that the upcoming results contribute to development of new therapeutic concepts for arteriosclerosis. Because of the strong anti-inflammatory and immune regulatory function of MSC, as well as their effect on renewing endothelial function [ 30 , 37 , 38 ], we considered that Ad-MSC administration is safe and may be useful in the treatment and prevention of arteriosclerosis. Additionally, Ad-MSC could serve as an effective adjuvant to the standard statin therapy of arteriosclerosis in order to accelerate improvement.…”

Section: Discussionmentioning

confidence: 99%

Autologous adipose mesenchymal stem cell administration in arteriosclerosis and potential for anti-aging application: a retrospective cohort study

Ohta¹,

Liu²,

Maeda³

2020

Stem Cell Res Ther

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Objective Arteriosclerosis is an age-related disease and a leading cause of cardiovascular disease. In animal experiments, mesenchymal stem cells and its culture-conditioned medium have been shown to be promising tools for prevention or treatment of arteriosclerosis. On the basis of these evidences, we aimed to assess whether administration of autologous adipose-derived mesenchymal stem cells (Ad-MSC) is safe and effective for treatment of arteriosclerosis. Methods We retrospectively reviewed clinical records of patients with arteriosclerosis who had received autologous Ad-MSC administration at our clinic. Patients’ characteristics were recorded and data on lipid profile, intimal-media thickness (IMT), cardio-ankle vascular index (CAVI), and ankle-brachial index (ABI) before and after Ad-MSC administration were collected and compared. Results Treatment with Ad-MSC significantly improved HDL, LDL, and remnant-like particle (RLP) cholesterol levels. No adverse effect or toxicity was observed in relation to the treatment. Of the patients with abnormal HDL values before treatment, the vast majority showed improvement in the values. Overall, the measurements after treatment were significantly increased compared with those before treatment (p < 0.01). In addition, decreases in LDL cholesterol and RLP levels were observed after treatment in patients who had abnormal LDL cholesterol or RLP levels before treatment. The majority of patients with pre-treatment abnormal CAVI values had improved values after treatment. In patients with available IMT values, a significant decrease in the IMT values was found after therapy (p < 0.01). All patients with borderline arteriosclerosis disease had improved laboratory findings after treatment. In general, post-treatment values were significantly decreased as compared with pre-treatment values. Of the patients with normal ABI values before treatment at the same time as CAVI, the vast majority remained normal after treatment. Conclusions These findings suggest that Ad-MSC administration is safe and effective in patients developing arteriosclerosis, thereby providing an attractive tool for anti-aging application.

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“…In experiments with adipose tissue perivascular MSCs (ASCs), we demonstrated decreased expression of a number of adhesion-associated proteins and altered transcriptional activity of genes encoding adhesion proteins and matrix 34 . A modified secretory profile and the resulting increase in the angiogenic potential of ASCs have been shown 35 .…”

Section: Discussionmentioning

confidence: 99%

Simulated microgravity modulates the mesenchymal stromal cell response to inflammatory stimulation

Ratushnyy

Yakubets

Andreeva

et al. 2019

Sci Rep

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The duration and distance of manned space flights emphasizes the importance of advanced elucidation of space flight factors and their effects on human beings. The exposure to inflammatory mediators under microgravity may contribute to the activity of different cells, perivascular stromal cells (MSCs) in particular. Inflammatory activation is now considered as a principal cue of MSC engagement in reparative remodeling. In the present paper, the effect of simulated microgravity (sµg) on TNFα-mediated priming of adipose tissue-derived MSC (ASCs) was examined. Sµg per se did not induce inflammatory-related changes, such as elevation of ICAM-1 and HLA-ABC expression, soluble mediator production, or shifting of the transcription profile in ASCs. Moreover, the attenuated ASC response to TNFα priming under sµg was manifested in decreased production of TNFα-dependent pleiotropic cytokines (IL-8 and MCP-1), matrix remodeling proteases, and downregulation of some genes encoding growth factors and cytokines. Time-dependent analysis detected the first signs of priming attenuation after 48 hours of 3D-clinorotation. A reduced response of MSCs to priming under sµg can be a negative factor in terms of MSC involvement in tissue remodeling processes.

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Angiogenic Activity of Human Adipose-Derived Mesenchymal Stem Cells Under Simulated Microgravity

Cited by 27 publications

References 29 publications

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

Autologous adipose mesenchymal stem cell administration in arteriosclerosis and potential for anti-aging application: a retrospective cohort study

Simulated microgravity modulates the mesenchymal stromal cell response to inflammatory stimulation

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