Angiogeneza u centralnom nervnom sistemu - uloga faktora rasta vaskularnog endotela

Lačković, Vesna; Kostić, Smiljana; Šternić, Nadežda; Kanjuh, Vladimir; Vukovic, Irena

doi:10.2298/vsp0501059l

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…Temporally and spatially regulated EC-SMC interactions are required for proper vessel assembly and function in cerebral vascularization (Kurz, 2009; Lackovic et al, 2005), yet knowledge of the specific molecular factors controlling regional cerebral vascular patterning in utero is incomplete. In the current study, analyses were undertaken to delineate a developmental basis of the cW defects identified in adult SM22-Cre + /DNMAML1 + mice and therefore to better characterize vSMC Notch signaling-dependent mechanisms operating during gestation that presumptively give rise to the variant adult phenotype.…”

Section: Discussionmentioning

confidence: 99%

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Yang

Banerjee

Proweller

2013

Developmental Biology

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The circle of Willis (cW) is a major arterial collateral structure interconnecting hemispheric circulation within the brain, and in humans, anatomical variation of the cW is linked to stroke risk. Our prior studies in adult mice deficient in vascular smooth muscle cell (vSMC) Notch signaling revealed altered cerebroarterial maturation and patterning, including an anatomically incompetent cW similar to human variants. However, a developmental dependency on Notch signaling for cW formation in this model remained uncharacterized. Through temporospatial embryonic analyses, we now demonstrate that cW assembly is a pre-natal process highly sensitive to vSMC Notch signals, whose absence results in delayed nascent vascular plexus formation and under-development of the cW including the key anterior communicating artery (AComA) interconnecting anterior forebrain circulation. Mutant embryos additionally feature reduced vSMC coverage, non-uniform calibers and asymmetric branching at bifurcations of the major proximal cerebral arteries. At the cellular level, a notable reduction in vascular endothelial cell proliferation exists in the region of AComA assembly despite the presence of Vegfa. Furthermore, Notch signaling-deficient vSMCs in developing cerebral vessels feature reduced Pdgfrβ and Jagged1 levels and impaired proliferation. These collective findings in the embryonic brain support studies in adult animals demonstrating a reliance on intact vSMC Notch signaling for optimal neovascular responses to angiogenic stimuli. Importantly, the new data provide unique insights into the native formation of the cW and underscore a pioneering developmental role for vSMC Notch signaling in regulating temporospatial assembly of the clinically relevant cW.

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Section: Discussionmentioning

confidence: 99%

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Yang

Banerjee

Proweller

2013

Developmental Biology

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“…The principal cell of the connective tissue is fibroblast because it produces elements of the extracellular matrix and the reticular lamina of the basement membrane as well (9). In adult age, fibroblasts are restricted to the tunica adventitia of the blood vessel, while the subendothelial layer is dominated by smooth muscle cells that are able to produce components of the extracellular matrix (ground substance and fibers) (12)(13)(14).…”

Section: Organization Of the Connective Tissue In The Vascular Wallmentioning

confidence: 99%

Modern view on the structure of the vascular extracellular matrix

Tanasković-Stanković¹,

Sazdanovic²,

Jovičić³

et al. 2015

Medicinski casopis

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Recent views on cytohistological characteristics and pathogenic mechanisms of atherosclerotic lesions types I, II and III

Vukovic¹,

Lačković²,

Raicević³

et al. 2010

VOJNOSANIT PREGL

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Angiogeneza u centralnom nervnom sistemu - uloga faktora rasta vaskularnog endotela

Cited by 3 publications

References 67 publications

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Modern view on the structure of the vascular extracellular matrix

Recent views on cytohistological characteristics and pathogenic mechanisms of atherosclerotic lesions types I, II and III

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