Angiogenesis Occurs Within the Intimal Proliferation That Characterizes Transplant Coronary Artery Vasculopathy

Atkinson, Carl; Southwood, Mark; Pitman, R. G.; Phillpotts, C.J.; Wallwork, J.; Goddard, Martin

doi:10.1016/j.healun.2004.03.012

Cited by 28 publications

(24 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Illustrated is anti-human von Willebrand factor staining of human endothelial cells in skin that was harvested from SCID mice without transfer of PBL (left) or 14 d after transfer of PBL (right), showing marked angiogenesis in association with leukocyte recruitment. much as they expressed adhesion molecules and MHC class II, suggesting that the angiogenesis response itself may promote leukocyte recruitment and activation (112). These observations are similar to those published by others in experimental models.…”

Section: Angiogenesis and Chronic Allograft Rejectionsupporting

confidence: 90%

Angiogenesis and Endothelial Cell Repair in Renal Disease and Allograft Rejection

Reinders

Rabelink

Briscoe

2006

Journal of the American Society of Nephrology

134

144

View full text Add to dashboard Cite

show abstract

Section: Angiogenesis and Chronic Allograft Rejectionsupporting

confidence: 90%

Angiogenesis and Endothelial Cell Repair in Renal Disease and Allograft Rejection

Reinders

Rabelink

Briscoe

2006

Journal of the American Society of Nephrology

134

144

View full text Add to dashboard Cite

show abstract

“…5). These molecules are known to promote monocyte adhesion to endothelium and migration into atherosclerotic plaques (2,7,21,37,44) via a mechanism that involves ligation of Mac-1 (CD11b/CD18 or ␣ M ␤ 2 ) and CD49d/CD29 (VLA-4) on the monocyte surface to ICAM-1 and VCAM-1 on the endothelial cells, respectively. Proinflammatory mediators responsible for endothelial activation may originate either from the lung or from circulating leukocytes such as monocytes.…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that circulating monocytes could also contribute to produce mediators that activate endothelial cells. Activation of endothelium is a key element in plaque instability, and expression of VCAM-1 and ICAM-1 in plaque tissue has been associated with new plaque vascularization, intraplaque bleeding, and vulnerability to rupture (2).…”

Section: Discussionmentioning

confidence: 99%

Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques

Yatera

Hsieh²,

Hogg³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

demiologic studies have shown an association between exposure to ambient particulate air pollution Ͻ10 m in diameter (PM10) and increased cardiovascular morbidity and mortality. We previously showed that PM10 exposure causes progression of atherosclerosis in coronary arteries. We postulate that the recruitment of monocytes from the circulation into atherosclerotic lesions is a key step in this PM10-induced acceleration of atherosclerosis. The study objective was to quantify the recruitment of circulating monocytes into vessel walls and the progression of atherosclerotic plaques induced by exposure to PM10. Female Watanabe heritable hyperlipidemic rabbits, which naturally develop systemic atherosclerosis, were exposed to PM10 (EHC-93) or vehicle by intratracheal instillation twice a week for 4 wk. Monocytes, labeled with 5-bromo-2Ј-deoxyuridine (BrdU) in donors, were transfused to recipient rabbits as whole blood, and the recruitment of BrdU-labeled cells into vessel walls and plaques in recipients was measured by quantitative histological methodology. Exposure to PM10 caused progression of atherosclerotic lesions in thoracic and abdominal aorta. It also decreased circulating monocyte counts, decreased circulating monocytes expressing high levels of CD31 (platelet endothelial cell adhesion molecule-1) and CD49d (very late antigen-4 ␣-chain), and increased expression of CD54 (ICAM-1) and CD106 (VCAM-1) in plaques. Exposure to PM10 increased the number of BrdU-labeled monocytes adherent to endothelium over plaques and increased the migration of BrdU-labeled monocytes into plaques and smooth muscle underneath plaques. We conclude that exposure to ambient air pollution particles promotes the recruitment of circulating monocytes into atherosclerotic plaques and speculate that this is a critically important step in the PM10-induced progression of atherosclerosis. atherosclerosis; adhesion molecules EPIDEMIOLOGIC STUDIES have associated exposure to ambient particulate air pollution Ͻ10 m in diameter (PM 10

show abstract

“…This type of intima formation seems to differ from the more rapid neointima formation in experimental animals, which mainly contains SMCs. 4,22 Because T cells are important producers of cytokines and chemokines, we have focused on the role of T cells in the wall of coronary arteries. Most cells were present in the adventitia and in the neointima.…”

Section: Discussionmentioning

confidence: 99%

The Chemokine and Chemokine Receptor Profile of Infiltrating Cells in the Wall of Arteries With Cardiac Allograft Vasculopathy Is Indicative of a Memory T–Helper 1 Response

et al. 2006

View full text Add to dashboard Cite

Background-Despite improvement in short-term patient survival after heart transplantation (HTx), long-term survival rates have not improved much, mainly because of cardiac allograft vasculopathy (CAV). Cytokines and chemokines are considered to play an important role in CAV development. Interleukin-4 and interleukin-10 were expressed at the same level in both HTx groups and references. In HTxϩCAV, all CϩCR, but especially the T-helper 1 (TH1) CϩCR, were more abundant than in the HTxϪCAV and references. However, TH2 CCR4 expression did not differ significantly between both HTx groups. Conclusions-In coronary arteries with CAV, most T cells are CD4 ϩ and express human leukocyte antigen DR. These activated TH cells are mainly memory TH1 cells on the basis of their CϩCR profile and cytokine expression. Methods and Results-We

show abstract

Angiogenesis Occurs Within the Intimal Proliferation That Characterizes Transplant Coronary Artery Vasculopathy

Cited by 28 publications

References 31 publications

Angiogenesis and Endothelial Cell Repair in Renal Disease and Allograft Rejection

Angiogenesis and Endothelial Cell Repair in Renal Disease and Allograft Rejection

Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques

The Chemokine and Chemokine Receptor Profile of Infiltrating Cells in the Wall of Arteries With Cardiac Allograft Vasculopathy Is Indicative of a Memory T–Helper 1 Response

Contact Info

Product

Resources

About