Angiogenesis Markers in Gynecological Tumors and Patents for Anti- Angiogenic Approach: Review

Abdalla, Douglas Reis; Simoens, Cindy; Bogers, Johannes; Murta, E F C; Michelin, Márcia Antoniazi

doi:10.2174/1574892810999150827153642

Cited by 12 publications

(11 citation statements)

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“…It is well-known that activated MMP-2 contributes to the angiogenic process by remodeling the basement membrane to allow sprouting and liberating matrix-bound angiogenic factors [28]. In addition, COX-2 overexpression in colon carcinoma cells increases their angiogenicity, as shown by an increased ability to stimulate endothelial cell migration and tube formation by producing prostaglandins such as prostaglandin E2 and inducing pro-angiogenic factors such as basic fibroblast growth factor [29–31].…”

Section: Discussionmentioning

confidence: 99%

ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

et al. 2016

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ING4, a potential tumor suppressor, is implicated in cell cycle arrest, apoptosis, cell migration and angiogenesis. Here, we investigated the clinical value of ING4 and its impact on angiogenesis in colorectal cancer (CRC). In this study, we found that ING4 expression was significantly reduced in CRC tissues versus paired normal colon tissues. Moreover, low ING4 expression was significantly associated with increased lymph node metastasis, advanced TNM stage and poor overall survival. Multivariate Cox regression analysis showed that ING4 expression was an independent favourable prognostic factor for CRC (hazard ratio = 0.45, P = 0.001). In addition, we found that ING4 strongly inhibited CRC angiogenesis by suppressing Sp1 expression and transcriptional activity through ubiquitin degradation and down-regulating the expressions of Sp1 downstream pro-angiogenic genes, MMP-2 and COX-2. Moreover, ING4 might inhibit phosphorylation activity of cyclin/CDK2 complexes to trigger Sp1 degradation by inducing p21 expression in despite of p53 status. Our findings imply that reduced ING4 expression in CRC resulted in increased angiogenesis and contributed to CRC metastasis and poor prognosis. Restoration of ING4 may be a novel strategy for the treatment of metastatic CRC.

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Section: Discussionmentioning

confidence: 99%

ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

et al. 2016

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“…Stromal expression of MMP-7 was higher also in serous compared to mucinous tumors; while the expression of MT1-MMP, MMP-7 and -9 was similar in benign and borderline tumors compared to control group [ 191 ]. A recent study also showed higher expression of VEGF, MMPs, CD105 (Endoglin), TIMPs and VASH (Vasohibin) on advanced gynaecological cancers compared to healthy individuals [ 192 ]. A screening study using an orthotopic ovarian carcinoma model in nude mice recently demonstrated that the mRNA levels of TIMP-2, MMP-2 and other ovarian cancer associated proteins such as cytokeratin -7 (CK-7), cancer antigen-125 (CA-125), tumor suppressor P53 and survivin, were significantly higher in cancer tissue than the middle paraneoplastic tissue and remote paraneoplastic tissue and normal ovarian tissue [ 193 ].…”

Section: Metzincins and Timps In Ovarian Cancermentioning

confidence: 99%

The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression

Escalona

Chan

Kannourakis

et al. 2018

IJMS

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Approximately sixty per cent of ovarian cancer patients die within the first five years of diagnosis due to recurrence associated with chemoresistance. The metzincin family of metalloproteinases is enzymes involved in matrix remodeling in response to normal physiological changes and diseased states. Recently, there has been a mounting awareness of these proteinases and their endogenous inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), as superb modulators of cellular communication and signaling regulating key biological processes in cancer progression. This review investigates the role of metzincins and their inhibitors in ovarian cancer. We propose that understanding the metzincins and TIMP biology in ovarian cancer may provide valuable insights in combating ovarian cancer progression and chemoresistance-mediated recurrence in patients.

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“…pH changes for values higher than 4.5 are easily found in women who presents bacterial vaginosis, being the immunological response in this case and for HPV infection are similar, with an expressive increase of cytokines for both. In this sense many studies in the literature abording immune response in different grades of cervical lesions, thus understanding how the immune system behaviour during HPV infection with or without vaginosis [13].…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Vaginal Infections in Women under Screening to HPV Infection and Cervical Lesions in Brazilian Basic Health Service

Francisco¹,

Rosa²,

Tatiane³

et al. 2018

Int Arch Med Microbiol

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Introduction: Vaginal infections and inflammations are responsible for the most demand at gynaecology, because the main complains are leucorrhea and vulvovaginitis, there is a specifically interest in cervix cancer prevention. Aim: The aim of this study is to understand the prevalence of vaginal infections cases and cervical lesions, found in women attended at health basic units from Igarapava, São Paulo state, Brazil. Methods: There were analyzed retrospectively 1,071 cases of cytopathological exams from SUS (Brazilian Unique System of Health) during the period of January 2013 to July 2016, patients from Igarapava city, São Paulo state. Results: Gardnerella vaginalis was the most commonly found microorganism in the four years studied with the highest prevalence in 2014 with 46.8%. This study identified that all cases of Gardnerella vaginalis are associated with Mobiluncus sp. Candida sp should decrease gradually over the years, in 2013 (36.9%) and 2016 (16.9%), as well as the decrease of normal bacterial flora (Lactobacillus) with 11% only in 2016. Trichomonas vaginalis should increase in 2016 (37.5%) compared to 2014 (31.2%), and finally just found two cases of cervical intraepithelial neoplasia grade I. Conclusion: In view of the values obtained from bacterial, fungal and protozoal genital infections, there is a need for a better follow-up of the women screened, both in terms of prevention of these infections, as well as infections related to the development of tumors, knowledge of the signs and symptoms of these infections, as well as specialization courses for professionals to better assist these women, in order to guarantee health and quality of life.

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Angiogenesis Markers in Gynecological Tumors and Patents for Anti- Angiogenic Approach: Review

Cited by 12 publications

References 0 publications

ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression

Prevalence of Vaginal Infections in Women under Screening to HPV Infection and Cervical Lesions in Brazilian Basic Health Service

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