Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART

Naicker, Thajasvarie; Phoswa, Wendy N.; Onyangunga, Onankoy; Gathiram, P.; Moodley, Jagidesa

doi:10.3390/ijms20153728

Cited by 11 publications

(5 citation statements)

References 126 publications

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“…Endothelial survival, proliferation, and migration are the main factors for angiogenic stimulation through increased soluble factor mediation (Demidova-Rice et al, 2012). The process of angiogenesis occurs because it begins with the initiation of Vascular Endothelial Growth Factors (VEGFs) and Placental Growth Factors (PlGFs) (Naicker et al, 2019). Pathology of female reproductive organs also affects the occurrence of angiogenesis disorders (Reynolds et al, 2002).…”

Section: Angiogenesismentioning

confidence: 99%

The Tissue Structure in the Remodeling Phase of a Vesicovaginal Fistula between the use of Freeze-Dried Amnion and Primary Suturing in Rabbit

Kurniawati¹,

Santoso²,

Rantam³

et al. 2022

AAVS

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V esicovaginal fistula, one of the complications of gynecological and obstetric procedures, is an abnormal opening between the bladder and vagina. These cases are still common in developing countries, with an estimate reaching at least three million women. Medical records in Africa show that 30,000-130,000 cases of vesicovaginal research Article Abstract | Background: One of the complications of gynecological and obstetric procedures is a vesicovaginal fistula. Surgery is the gold standard but the success rate has not yet reached 100%. The wound healing process needs to be supported by certain ingredients such as regenerative medicine. Amnion is easy to find and rich in growth substances. Aim: This study analyzed the comparison of tissue structure in the remodeling phase of the vesicovaginal fistula between the use of freeze-dried amnion and primary suturing on day 21. Materials and Methods: This experimental study used New Zealand rabbits which were female and weighed 3-4.5 kg. The first stage of the study created a model of a vesicovaginal fistula. The second stage of the study closed the vesicovaginal fistula which was successfully created in the first stage. The study used a post-test-only control group design. The histological examination included fibroplasia, angiogenesis, re-epithelialization, and collagen deposition on day 21. Data were analyzed descriptively and statistically. results:The mean scores of angiogenesis, fibroplasia, re-epithelialization, and collagen deposition in a New Zealand rabbit model of vesicovaginal fistula sutured with human amniotic stem cell seeding were higher than rabbits without amniotic stem cell seeding, the stem cell injection group, and the control group. There was a significant difference between groups only in angiogenesis at day 21. conclusion: Freeze-dried amnion plays a role in the wound healing process, especially in angiogenesis in the vesicovaginal fistula repair model. The use of freeze-dried amnion can be applied to assist the wound healing process in patients but still needs to be studied in humans.

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Section: Angiogenesismentioning

confidence: 99%

The Tissue Structure in the Remodeling Phase of a Vesicovaginal Fistula between the use of Freeze-Dried Amnion and Primary Suturing in Rabbit

Kurniawati¹,

Santoso²,

Rantam³

et al. 2022

AAVS

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“…Also, ART may cause direct endothelial injury and promote endothelial dysfunction [ 26 ], which is an important risk factor for CVDs. Although ART and HIV have been associated with CVDs, such findings are yet to be established in HIV pregnant women [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the impact of HIV infection and anti-retroviral treatment on the cardiometabolic health of pregnant mothers and their offspring (ARTMOMSBABES)

Nkeh-Chungag

Engwa

Businge

et al. 2021

BMC Cardiovasc Disord

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Background The risk of cardiovascular diseases (CVDs) is becoming more prevalent in pregnant women though not much data is available for pregnant women with human immunodeficiency virus (HIV). Foetoplacental vascular endothelial dysfunction is thought to be at the origin of chronic diseases such as diabetes and obesity later on in life. Because HIV and anti-retroviral treatment (ARTs) are associated with endothelial dysfunction, children exposed in utero to these conditions may be at greater risk of developing CVDs. Despite the high prevalence of HIV in pregnant South African women, little is known about the effects of ART on the cardiovascular health of the mother and offspring. Hence, the proposed study intends to investigate how HIV/ARTs may affect the cardiovascular health of the mother and offspring at different time points during the pregnancy and up to 2 years after birth. Methods A longitudinal case–control study in HIV positive pregnant women on ART and HIV negative pregnant women will be conducted. All pregnant women will be assessed for cardio-metabolic risk factors and markers (lipids, anthropometric and glycaemic indies, oxidative stress), hemodynamic status (blood pressure parameters) and vascular function (arterial compliance, retinal microvasculature, uterine artery mean pulsatility index). Child health will be monitored in utero and postnatally via routine foetal health screening, placental integrity, anthropometry, blood pressure parameters, markers of oxidative stress and endothelial function in cord blood and cardiovascular epigenetic markers in urine. Discussion There is a paucity of studies in South Africa and sub-Sahara Africa as a whole that utilised a longitudinal study model to assess the effects of ARTs on vascular endothelial changes in pregnant women living with HIV and the cardiometabolic health of their offspring. This study will therefore help to monitor changes in cardiometabolic risk during pregnancy and in children exposed in utero to HIV-infection and ART use. Findings from this study will provide useful information for developing guidelines on the use of ARTs in pregnancy and management of cardiometabolic health of the offspring of HIV positive mothers.

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“…In South Africa, PE affects about 5% of pregnant women and 12% of primigravidae (14,15). Although the cause(s) of PE remain unclear, it is thought to stem from placental malfunction during pregnancy (16) resulting in foetal hypo-perfusion associated with oxidative stress and low-grade inflammation (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry

Nkeh-Chungag

Engwa

Businge

et al. 2021

Front. Cardiovasc. Med.

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Background: It has been reported that maternal gestational environment may be programmed to have a significant impact on foetal and offspring health later in life. Studies have shown that children born to pre-eclamptic mothers are prone to obesity, hypertension, and diabetes in their adult life. However, such findings are yet to be established in an African population. This protocol is for a study aiming to investigate the relationship between pre-eclampsia (PE) and cardiovascular risk in children born to pre-eclamptic mothers in a South African population of African descents.Methods: A prospective case-control design will be employed to recruit pre-eclamptic and normotensive pregnant women and their offspring after birth. Pregnant women will be assessed for cardiovascular risk factors including PE, obesity, haemodynamics, lipids, glycaemic indices, oxidative stress, and vascular function at 30 weeks of gestation. The cardiovascular risk profile of their offspring will be assessed at birth and 6 weeks later. The difference in cardiovascular risk profile between children born to the pre-eclamptic and normotensive mothers will be compared and the correlation between maternal and offspring cardiovascular risks will be investigated.Discussion: This will be the first prospective study to assess the in-utero effect of cardiovascular risk in offspring born to pre-eclamptic women of African ancestry. It is expected that findings from this study will provide information on the cardiovascular effect of in-utero exposure to PE in a population of African ancestry. This knowledge will advise policy on the management of women with PE with a view of protecting cardiovascular health in offspring.

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Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART

Cited by 11 publications

References 126 publications

The Tissue Structure in the Remodeling Phase of a Vesicovaginal Fistula between the use of Freeze-Dried Amnion and Primary Suturing in Rabbit

The Tissue Structure in the Remodeling Phase of a Vesicovaginal Fistula between the use of Freeze-Dried Amnion and Primary Suturing in Rabbit

Assessment of the impact of HIV infection and anti-retroviral treatment on the cardiometabolic health of pregnant mothers and their offspring (ARTMOMSBABES)

Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in-utero: A Prospective Case-Control Study in South African Children of African Ancestry

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