2002
DOI: 10.1002/jemt.10249
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Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix

Abstract: Angiogenesis is critical to wound repair. Newly formed blood vessels participate in provisional granulation tissue formation and provide nutrition and oxygen to growing tissues. In addition, inflammatory cells require the interaction with and transmigration through the endothelial basement membrane to enter the site of injury. Angiogenesis, in response to tissue injury, is a dynamic process that is highly regulated by signals from both serum and the surrounding extracellular matrix (ECM) environment. Vascular … Show more

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Cited by 619 publications
(477 citation statements)
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“…[1][2][3] One process critical to wound repair is angiogenesis, the development of new blood vessels. 4 One of the most potent proangiogenic molecules is vascular endothelial growth factor A (VEGF-A). Produced by a variety of cells including macrophages, 5 VEGF-A can bind to Flk1 (VEGF-R2) on endothelial cells to induce migration and proliferation.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…[1][2][3] One process critical to wound repair is angiogenesis, the development of new blood vessels. 4 One of the most potent proangiogenic molecules is vascular endothelial growth factor A (VEGF-A). Produced by a variety of cells including macrophages, 5 VEGF-A can bind to Flk1 (VEGF-R2) on endothelial cells to induce migration and proliferation.…”
Section: Introductionmentioning
confidence: 99%
“…14 Many of the known proangiogenic factors are products of cells that infiltrate during the inflammatory phase. 4 Macrophages, for instance, are sources of both proangiogenic and antiangiogenic factors. Such factors can affect blood vessel development by modifying the extracellular matrix, 15 affecting the growth factor milieu, 16,17 and guiding vessel anastomosis.…”
Section: Introductionmentioning
confidence: 99%
“…Angiogenesis is critical to wound repair. The process is important to provide nutrition and oxygen to growing tissues 26 . A wide variety of plant-based compounds have been reported to act in angiogenesis process; these compounds include polyphenols, alkaloids, terpenoids and tannins 27 .…”
Section: ■ Discussionmentioning
confidence: 99%
“…19 We used fibrin matrix since it is a physiologically relevant provisional scaffold that supports cells during tissue repair, tumor growth and neovascularization and its formation is naturally followed by remodeling processes. 20,21 In addition, vascular diseases like arteriosclerosis and restenosis are characterized by deposition of fibrin in the vascular wall that is followed by invasion and proliferation of VSMCs. 22 Although there are reports where aSMA-positive cells are found in the proximity of sprouting endothelial cells, 23,24 a majority of articles published to date describe the aortic sprouts as solely endothelial structures.…”
Section: Discussionmentioning
confidence: 99%