Angiogenesis in head and neck cancer: An overview

Prakash, Roopan; Mohan, Vishnu; Gopinathan, Pillai Arun; Nair, Manoj S.; Bai, Jin-si

doi:10.4103/jioh.jioh_192_18

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…Several studies have been proposed to evaluate angiogenesis in premalignant lesions. In some, an increase in blood vessels is observed as the lesion progresses to malignancy, with fewer vessels observed in the normal epithelium, an increased number in epithelial dysplasia and an even higher prevalence in OSCC (Orakash et al, 2018;Iamaroon et al, 2003;Michailidou et al, 2008;Mohtasham et al, 2010;Gandolfo et al, 2011). Another study showed no difference between normal tissue and epithelial dysplasia, with significant difference only observed between OSCC and normal tissue, which corroborates the findings of this search (Shivamallappa et al, 2011).…”

Section: Discussionsupporting

confidence: 80%

“…This method allows a minor error in the results because the examiner variable was eliminated during the count. The literature provides several methodologies, in accordance to the number of reviewed fields and the magnification used for counting (Orakash et al, 2018;Carla et al, 2012;Shieh et al, 2004;Michailidou et al, 2008;Mohtasham et al, 2010;Shivamallappa et al, 2011). In this research paper, the field with the highest density in 200x magnification was selected.…”

Section: Discussionmentioning

confidence: 99%

“…However, a gradual increase in micro vessel density, compared to normal tissue, has been described in premalignant lesions that originated in the uterus (Zyla et al, 2014), stomach (Feng et al 2002, thyroid (Rajabi et al, 2019), and dysplastic nevi (Einspahr et al, 2007). Some studies of oral tumors have shown that the progression from normal tissue to epithelial dysplasia and squamous cell carcinoma (OSCC) is associated with increased vascularization (Orakash et al, 2018;Abbas et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mast Cells and Blood Vessels Profile in Oral Carcinogenesis: An Immunohistochemistry Study

Teófilo

Ferreira

Batista

et al. 2020

Asian Pac J Cancer Prev

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Angiogenesis is the emergence of new blood vessels from pre-existing capillaries. It is an essential step in tumor growth and metastasis because the new blood vessels provide oxygen and nutrition to the cells that are proliferating and facilitate the drainage of metabolites, in addition to functioning as a means of transportation for tumor cells (Souza et al., 2007). According to Folkman, cancer begins as avascular nodules (Folkman, 1971) and is only able to grow beyond 2 millimeters in three

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mast Cells and Blood Vessels Profile in Oral Carcinogenesis: An Immunohistochemistry Study

Teófilo

Ferreira

Batista

et al. 2020

Asian Pac J Cancer Prev

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“…Однако, использование антионкогенного потенциала эндостатина в терапии ПКПР может быть не менее эффективным ввиду анатомических и патофизиологических особенностей данного типа опухоли. Прежде всего, это обильная васкуляризация злокачественных новообразований челюстно-лицевой области, которая значительно усугубляет лечение онкологических пациентов, существенно повышая риск возникновения осложнений в виде кровотечений [37,38]. Кроме того, результаты недавних исследований свидетельствуют о существенном снижении уровня белка эндостатина в сыворотке крови пациентов с ПКПР по сравнению со здоровыми людьми.…”

Section: Reviewsunclassified

Analysis of the anticancer effect of endostatin on oral squamous cell carcinoma based on results of experimental studies

Tuguzbaeva¹,

Павлов²,

Еникеев³

2020

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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При плоскоклеточном раке полости рта основной причиной летальных исходов является метастазирование в регионарные лимфатические узлы. Злокачественный рост и формирование метастазов напрямую зависят от степени кровоснабжения первичного очага новообразования. Известно, что по мере прогрессирования опухолевый процесс сопровождается нарушением сбалансированной в норме системы регуляции ангиогенеза с превалированием уровня ангиогенных стимуляторов над ингибиторами. В связи с этим, использование антиангиогенных средств является патофизиологически обоснованным методом борьбы со злокачественным ростом. В обзоре обсуждаются данные доклинических исследований участия эндостатина, природного ингибитора ангиогенеза, в процессах подавления прогрессии и метастазирования плоскоклеточного рака челюстно-лицевой области. Проанализированы патогенетические механизмы ингибирования эндостатином опухолевого роста в экспериментальных моделях рака полости рта. Эндостатин можно рассматривать в качестве потенциального противоопухолевого средства для лечения данной нозологии. The main reason for cancer-associated mortality in patients with oral squamous cell carcinoma is metastatic spread to regional lymph nodes. It is known that the processes of malignant growth and metastasis are highly dependent on blood supply to the primary cancerous focus. The development of malignancy is accompanied by failure of the normally well-balanced system of angiogenesis regulation with prevalence of proangiogenic factors over inhibitors. Therefore, the use of angiogenic inhibitors is a pathophysiologically justified method aimed at suppression of cancer progression. This review presents reports of experimental studies on the role of endostatin, a natural inhibitor of angiogenesis, in processes of tumour shrinkage in squamous cell carcinoma of the maxillofacial region. The authors analysed pathogenic mechanisms of the anticancer effects exhibited by endostatin in preclinical models of oral malignancy. Endostatin can be regarded as a potential antitumor agent for the treatment of oral squamous cell carcinoma.

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Biosynthesized nanoparticles (gold, silver and platinum): Therapeutic role in angiogenesis

Haque

Patra

2021

Comprehensive Analytical Chemistry

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Angiogenesis in head and neck cancer: An overview

Cited by 4 publications

References 5 publications

Mast Cells and Blood Vessels Profile in Oral Carcinogenesis: An Immunohistochemistry Study

Mast Cells and Blood Vessels Profile in Oral Carcinogenesis: An Immunohistochemistry Study

Analysis of the anticancer effect of endostatin on oral squamous cell carcinoma based on results of experimental studies

Biosynthesized nanoparticles (gold, silver and platinum): Therapeutic role in angiogenesis

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