Angiogenesis in ductal breast carcinoma. Comparison of microvessel density between primary tumour and lymph node metastasis

Arapandoni-Dadioti, Petroula; Giatromanolaki, Alexandra; Trihia, Helen; Harris, Adrian L.; Koukourakis, Michael I.

doi:10.1016/s0304-3835(98)00343-7

Cited by 25 publications

(15 citation statements)

References 11 publications

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“…Vessel density analysis in various malignant tumors revealed a correlation with tumor invasion, metastasis, and poor prognosis [22][23][24][25][26]. Breast carcinoma with high vascularity has been reported to show a higher incidence of node metastasis and a worse prognosis [22,41]. However, in our study, microvessel counts showed no correlation with venous invasion or lymph node metastasis.…”

Section: Discussioncontrasting

confidence: 69%

The Role of Thymidine Phosphorylase and Thrombospondin-1 in Angiogenesis and Progression of Intrahepatic Cholangiocarcinoma

Aishima¹,

Taguchi²,

Sugimachi³

et al. 2002

Int J Surg Pathol

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Thymidine phosphorylase (TP), an important regulator of angiogenesis, is correlated with progression, metastasis, and prognosis in various types of tumor. In contrast, both positive and negative effects of thrombospondin-1 (TSP-1) on angiogenesis have been reported. In the present study, we examined the expression of TP and TSP-1 in carcinoma cells in 67 primary intrahepatic cholangiocarcinomas (ICCs) immunohistochemically and its correlation with angiogenesis, clinicopathological features, and prognosis. Twenty-six (38.8%) cases were classified as exhibiting positive TP expression. TP expression showed a significant correlation with vascular invasion, lymphatic permeation, perineural invasion, and lymph node metastasis. Thirty-four (50.7%) cases were classified as exhibiting positive TSP-1 expression. TSP-1 expression was significantly correlated with only lymphatic permeation. The microvessel count in positive TP expression cases was significantly higher than that in negative cases. In contrast, the microvessel count in negative TSP-1 expression cases was significantly higher than that in positive cases. Survival in patients who were positive for both TP and TSP-1 expression was significantly poor. Our results suggest that the increased TP expression and decreased TSP-1 expression contribute to angiogenesis, but that the role of angiogenesis in ICC is not closely related to tumor aggressiveness. The TP and TSP-1 expression in ICC may enhance tumor aggressiveness.

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Section: Discussioncontrasting

confidence: 69%

The Role of Thymidine Phosphorylase and Thrombospondin-1 in Angiogenesis and Progression of Intrahepatic Cholangiocarcinoma

Aishima¹,

Taguchi²,

Sugimachi³

et al. 2002

Int J Surg Pathol

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“…angiogenic ability of the tumor, 17) we examined tumor angiogenesis by immunohistochemical staining using anti-CD31 antibody in tumors treated with kigamicin D in comparison with that in untreated tumors. [18][19][20][21][22] After immunohistochemistry with CD-31 antibody, the microvessel density was calculated according to the reported method. No significant difference in microvessel density was observed between the tumors in the treatment group and the control group (MVD: control 196.9±38.9 vessels/mm 2 ; treated 210.4±32.3 vessels/mm 2 ) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Kigamicin D, a novel anticancer agent based on a new anti‐austerity strategy targeting cancer cells' tolerance to nutrient starvation

et al. 2004

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Both tolerance to nutrient starvation and angiogenesis are essential for cancer progression because of the insufficient supply of nutrients to tumor tissue. Since chronic nutrient starvation seldom occurs in normal tissue, cancer's tolerance to nutrient starvation should provide a novel target for cancer therapy. In this study, we propose an anti-austerity strategy to exploit the ability of agents to eliminate cancer cells' tolerance to nutrient starvation. We established a simple screening method for agents that inhibit cancer cell viability preferentially during nutrient starvation, using PANC-1 cell line cultured in nutrient-rich and nutrientdeprived media. ancers always have deformed, deficient vascular and lymphatic systems due to excessive and unregulated tumor cell growth, as well as improper and insufficient angiogenesis. As a result, perfusion within cancers is inadequate, and the cancers contain regions that are transiently and chronically exposed to nutrient starvation. 1) These microenvironmental inadequacies are present from the earliest stage in the development of cancers, and are fully established while the neoplasm is still microscopic in size. 2) Since nutrient starvation occurs in tumor tissue that is >100-200 µm away from a functional blood supply, 3) tumor survival depends, in part, on the ability to recruit new blood microvessels via angiogenic factors. This affords tumor cells the ability to survive and propagate in a hostile environment, 4) and thus increased angiogenesis by a malignancy is related to a poor prognosis. 5,6) Because of this, antiangiogenic therapy was postulated to be the most promising and specific approach to cancer therapy. Already, extensive studies have been conducted in an attempt to prevent tumor angiogenesis.However, Yu et al. recently suggested that tumors may be able to elude the effect of angiogenesis inhibitors, since antiangiogenic therapy targets genetically stable endothelial cells in the tumor vasculature, and genetic alterations that decrease the vascular dependence of tumor cells can influence the response of tumors to this therapy. 7) The well-known observation that hypovascularity is an outstanding characteristic of pancreatic cancers in diagnostic images suggests that pancreatic cancer tissue has a poor blood supply. 8) However, since pancreatic cancers are known to be among the most aggressive malignancies despite their poor blood supply, we proposed that cancer cells' tolerance of insufficient nutrient might be an important determinant of malignancy. 9) Although the mechanism of tolerance has not yet been fully elucidated, the PI-3K-Akt pathway and AMPK have been found to be involved. 10) Because the blood supply of normal tissue is regulated in a sophisticated manner, angiogenesis is seldom activated in normal healthy adult tissues, except in the female reproductive system. 11) The same is true for nutrient starvation. We therefore speculated that if some compound could abolish cancer cells' tolerance of nutrient starvation, it might be capable of be...

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“…Angiogenesis is considered a distinct and independent prognostic factor from tumor cell morphology. MVD counts were selected for this study as the surrogate of angiogenesis, and have been used widely for this purpose (37)(38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology

Turetschek¹,

Floyd²,

Shames³

et al. 2001

Magnetic Resonance in Med

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The diagnostic potential of a new rapid clearance blood pool contrast medium (P792; MW ‫؍‬ 6.47 kDa) for the MR assessment of microvessel characteristics was assessed in 42 chemicallyinduced breast tumors, with comparisons to albumin-(Gd-DTPA). Microvessel characteristics, including the transendothelial permeability (K PS ) and the fractional blood volume (fPV), were estimated by using dynamic MR data fit to a bidirectional twocompartment model. The MR-derived estimates for K PS and fPV using each contrast agent were compared, and assays using each contrast agent were correlated to the histologic tumor grade (SBR score) and the microvascular density (MVD) counts. Using P792-enhanced data, neither K PS nor fPV showed a statistically significant correlation with the tumor grade or the MVD (P > .05). Conversely, using albumin-(GdDTPA) 30

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Angiogenesis in ductal breast carcinoma. Comparison of microvessel density between primary tumour and lymph node metastasis

Cited by 25 publications

References 11 publications

The Role of Thymidine Phosphorylase and Thrombospondin-1 in Angiogenesis and Progression of Intrahepatic Cholangiocarcinoma

The Role of Thymidine Phosphorylase and Thrombospondin-1 in Angiogenesis and Progression of Intrahepatic Cholangiocarcinoma

Kigamicin D, a novel anticancer agent based on a new anti‐austerity strategy targeting cancer cells' tolerance to nutrient starvation

Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology

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