2004
DOI: 10.1002/hep.20193
|View full text |Cite
|
Sign up to set email alerts
|

Angiogenesis in chronic inflammatory liver disease

Abstract: Intrahepatic hypoxia may occur during the inflammatory and fibrotic processes that characterize several chronic liver diseases of viral and autoimmune origin. As a consequence, new vascular structures are formed to provide oxygen and nutrients. Angiogenesis involves a tightly regulated network of cellular and molecular mechanisms that result in the formation of functional vessels. Of particular importance are growth factors, molecules involved in matrix remodeling and cell migration, and vessel maturation-rela… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

7
212
0
5

Year Published

2007
2007
2015
2015

Publication Types

Select...
4
4

Relationship

0
8

Authors

Journals

citations
Cited by 201 publications
(227 citation statements)
references
References 117 publications
7
212
0
5
Order By: Relevance
“…The morphology and phenotype of the CD146 1 /KDR 1 /CD31 1 /CD144 1 /CD45 2 cell population were similar to those of circulating ECFCs, the only subpopulation capable of forming vessels in vivo (16). They were more frequent in patients than in donors, which is in line with the current view that hepatic inflammation and fibrogenesis are frequently associated with angiogenesis (29).…”
Section: Discussionsupporting
confidence: 84%
“…The morphology and phenotype of the CD146 1 /KDR 1 /CD31 1 /CD144 1 /CD45 2 cell population were similar to those of circulating ECFCs, the only subpopulation capable of forming vessels in vivo (16). They were more frequent in patients than in donors, which is in line with the current view that hepatic inflammation and fibrogenesis are frequently associated with angiogenesis (29).…”
Section: Discussionsupporting
confidence: 84%
“…4,15) HIF-1α then activates the transcription of genes such as VEGF, which are directly or indirectly involved in angiogenesis. 15,16) VEGF is a major regulator of vascular formation and remodeling through effects on EC activation and proliferation.…”
Section: Initiation and Regulation Of Angiogene-sismentioning
confidence: 99%
“…4,15) HIF-1α then activates the transcription of genes such as VEGF, which are directly or indirectly involved in angiogenesis. 15,16) VEGF is a major regulator of vascular formation and remodeling through effects on EC activation and proliferation. 17) VEGF is mediated via two tyrosine kinase receptors, VEGF receptor 1 (VEGFR-1, Flt-1) and VEGFR-2 (KDR, Flk-1), which are mainly expressed on EC.…”
Section: Initiation and Regulation Of Angiogene-sismentioning
confidence: 99%
“…To determine whether the vascular malformations of embryonic liver were a prerequisite for the development of the adult liver disease, we took advantage of the ability of the liver to regenerate after hepatectomy as a model of liver angiogenesis. 25 Two-month-old adult mice were subjected to partial hepatectomy and sacrificed 20 days later. In each Tg mouse assessed (n ϭ 5), the regenerated lobule was found to be smaller than the non-Tg one (n ϭ 4) ( Figure 4I) and to show severe vascular malformations (including large vessels crawling at its surface, decreased branching, and clustered capillaries sprouting from them) (Figure 4, I [d] and M), even more severe than those observed in the nonhepactectomized lobules of the same Tg mouse ( Figure 4L).…”
Section: The Liver Vascular Malformations Arise Early During Organogementioning
confidence: 99%