Angiogenesis in Carotid Atherosclerotic Lesions Is Associated with Timing of Ischemic Neurological Events and Presence of Computed Tomographic Cerebral Infarction in the Ipsilateral Cerebral Hemisphere

Contrast-Enhanced Ultrasound for the Evaluation of Neovascularization in Atherosclerotic Carotid Artery Plaques

“…6 Here, the high contrast Histopathology revealed an inverse correlation between neovessel density and time from the ischemic event to carotid endarterectomy, suggesting that significant angiogenesis occurs soon before an episode of plaque instability and regresses thereafter as remodeling. 7 Our findings support this hypothesis although the results were not statistically significant ( Figure II in the online-only Data Supplement).…”

Increased vascularization of shoulder regions of carotid atherosclerotic plaques from patients with diabetes

“…A mechanistic link between vascularization, intraplaque hemorrhage, and the clinical event has been proposed, and some support for this hypothesis has been presented. 29 A limitation of the current report is that we exclusively studied symptomatic plaques. It would be interesting to see if similar patterns were found in patients without previous symptoms.…”

Immunohistochemical study of the role of mast cells and macrophages in the process of angiogenesis in the atherosclerotic plaques in patients with metabolic syndrome

“…Все эти факторы потенцируют сложные взаимодействия различных со-ставляющих -воспаления, липидного обмена, системы свертывания крови, гипоксии, апоптоза, иммунного от-вета. Нестабильность атеросклеротической бляшки явля-ется относительно независимым фактором риска разви-тия ишемического инсульта [3][4][5][6][7].…”

“…по 9]. В атероскле-ротических бляшках ангиогенез способствует формирова-нию новых микрососудов, их рост происходит в участках бляшки, склонных к разрыву и подвергающихся постоян-ным изменениям, реконструкциям [7]. Образование но-вых сосудов способствует росту атеросклеротических по-ражений и является ключевым фактором, приводящим к разрыву и дестабилизации бляшки [10,11].…”