Angiogenesis in Canine Mammary Tumours: A Morphometric and Prognostic Study

Sleeckx, N.; Brantegem, Leen Van; Eynden, G. Van den; Fransén, Erik; Casteleyn, Christophe; Cruchten, Steven Van; Kroeze, Edwin Veldhuis; Ginneken, Chris Van

doi:10.1016/j.jcpa.2013.09.005

Cited by 16 publications

(21 citation statements)

References 45 publications

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“…The association between angiogenesis and mammary tumors has been a common subject of interest in humans and dogs [32–34]. In fact, human breast cancer progression is associated with robust angiogenic activity [35].…”

Section: Inflammatory Cells and Sustained Angiogenesismentioning

confidence: 99%

“…Similarly, in veterinary medicine, the presence of proliferating endothelial cells and blood vessels in intratumoral and peritumoral regions of benign and malignant canine mammary tumors was shown, with the peritumoral regions having the largest blood vessel area and perimeter. Furthermore, malignant tumors have significantly more new vessels and proliferating endothelial cells compared with benign tumors and normal mammary gland tissues [32]. We have shown previously that high microvessel density in canine mammary cancer was significantly correlated with tubule formation, with the histological grade of malignancy and with clinical stage [37].…”

Section: Inflammatory Cells and Sustained Angiogenesismentioning

confidence: 99%

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A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs

Carvalho

Silva-Carvalho

Pires

et al. 2016

BioMed Research International

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Infiltrating cells of the immune system are widely accepted to be generic constituents of tumor microenvironment. It has been well established that the development of mammary cancer, both in humans and in dogs, is associated with alterations in numbers and functions of immune cells at the sites of tumor progression. These tumor infiltrating immune cells seem to exhibit exclusive phenotypic and functional characteristics and mammary cancer cells can take advantage of signaling molecules released by them. Cancer related inflammation has an important role in mammary carcinogenesis, contributing to the acquisition of core hallmark capabilities that allow cancer cells to survive, proliferate, and disseminate. Indeed, recent studies in human breast cancer and in canine mammary tumors have identified a growing list of signaling molecules released by inflammatory cells that serve as effectors of their tumor-promoting actions. These include the COX-2, the tumor EGF, the angiogenic VEGF, other proangiogenic factors, and a large variety of chemokines and cytokines that amplify the inflammatory state. This review describes the intertwined signaling pathways shared by T-lymphocytic/macrophage infiltrates and important tissue biomarkers in both human and dog mammary carcinogenesis.

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Section: Inflammatory Cells and Sustained Angiogenesismentioning

confidence: 99%

Section: Inflammatory Cells and Sustained Angiogenesismentioning

confidence: 99%

A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs

Carvalho

Silva-Carvalho

Pires

et al. 2016

BioMed Research International

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“…BC seriously threatens human health and life (1). Endothelial cells (ECs) play critical roles in the tumor microenvironment and in angiogenesis, which are essential for the growth, proliferation and migration of cancer cells (2,3). ECs are regarded as a significant target for antitumor angiogenesis and various anti-angiogenic drugs have been applied in the clinic (4).…”

Section: Introductionmentioning

confidence: 99%

Targeting of MCT1 and PFKFB3 influences cell proliferation and apoptosis in bladder cancer by altering the tumor microenvironment

Wang

Liu

et al. 2016

Oncology Reports

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Abstract. Phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3) and monocarboxylate transporter 1 (MCT1) play important roles in tumor endothelial cells (ECs) and several biological processes. The present study was conducted to study the effects of PFKFB3 and MCT1 on cell proliferation and apoptosis in the tumor microenvironment by co-culture of HUVECs and T24, a bladder cancer (BC) cell line, using a microfluidic device. Immunofluorescence assay showed that HUVEC activity was significantly enhanced under co-culture with T24 cells, according to the stronger fluorescence intensity of CD31 and CD105 than that in the signal-cultured cells. Quercetin treatment inhibited MCT1 expression but did not affect PFKFB3 expression. Knockdown of MCT1 or/and PFKFB3 increased the apoptosis rate of the HUVECs under single-culture and co-culture situations by staining with calcein and propidium iodide. Meanwhile, cell proliferation and lactic concentration were significantly decreased after the blocking of MCT1 or/and PFKFB3, as compared with that in the control group. No obvious differences in the effects on apoptosis, proliferation and lactic concentration were found between cells treated with quercetin and siMCT1. Thus, we concluded that the targeting of MCT1 and PFKFB3 regulated cell proliferation and apoptosis in BC cells by altering the tumor microenvironment, and quercetin exhibited a potential antitumor effect by targeting MCT1.

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“…O carcinoma mamário simples é o tipo de câncer de maior incidência em cadelas, com um alto índice de morbidade e mortalidade. Tais tumores podem acometer uma ou mais glândulas mamárias, sendo complicado o seu diagnóstico devido à sua grande variedade morfológica (SLEECKX et al, 2014).…”

Section: Introductionunclassified

“…A diferenciação entre tumores malignos e benignos levam em consideração algumas características. Os tumores benignos possuem um crescimento invasivo e normalmente são encapsulados, já os tumores malignos apresentem quadros de necrose, células diferenciadas, pleomorfismo nuclear e alta densidade vascular(SLEECKX et al, 2014).Os tumores mamários são considerados uma das doenças mais comuns em cadelas.Embora a prevalência dos cânceres mamários esteja caindo nas regiões com uma maior incidência da ovariosalpingoesterectomia, ainda permanece como uma patologia a ser considerada em medicina veterinária(SLEECKX et al, 2011).As glândulas abdominais caudais e inguinais são as mais afetadas, em que múltiplos tumores podem acometer o mesmo animal(SORENMO et al, 2009).Em um estudo feito porSorenmo et al (2009) os tumores malignos foram encontrados com maior frequência em animais mais velhos e, com um maior tamanho quando comparados com os tumores benignos. Os casos não malignos foram estudados periodicamente, mostrando que o mesmo pode evoluir para uma forma maligna.…”

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<b>Influência do estrógeno e progesterona na ativação in-vitro da indoleamina 2,3 dioxigenase-IDO- em células presentes no microambiente do carcinoma mamário de cadelas</b>

Bianchi¹

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Aos meus pais Carlos Alberto Bianchi e Lise Maria Kastein Faria da Cunha Bianchi o meu eterno agradecimento. Sem vocês nada disso seria possível. A minha irmã, Tatiane Kastein Faria da Cunha Bianchi, por sempre estar ao meu lado me ajudando, a sua presença é essencial em minha vida A minha pequena sobrinha, Manuela Bianchi por simplesmente me fazer sorrir. Você me fez ver a vida com mais alegria. Ao meu grande amor, Gabriela Bezerra Pucci, por estar ao meu lado em todos os momentos, me ouvindo, aconselhando e principalmente, compartilhando todas as glorias e dificuldades. Você foi essencial para a conclusão desta jornada. Aos meus avos paternos e maternos deixo aqui a minha gratidão por sempre participarem da minha vida, mostrando-me as suas melhores faces. Aos meus colegas de pós-graduação, Renata Silva, Rafael Magdanelo, Flavia Ponce, Tulio Yoshinaga e Aline Poscai. Os momentos com vocês foram especiais. Ao meu orientador Prof. Dr. José Roberto Kfoury Junior, pela sua imensa paciência, dedicação e competência. Muito obrigado por me receber e por me acompanhar durante essa estapa de minha vida. A todos os professores do programa de Anatomia dos Animais Domésticos e Silvestres. A prof. Dra. Paula de Carvalho Papa, pela confiança durante o uso do seu laboratório.

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Angiogenesis in Canine Mammary Tumours: A Morphometric and Prognostic Study

Cited by 16 publications

References 45 publications

A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs

A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs

Targeting of MCT1 and PFKFB3 influences cell proliferation and apoptosis in bladder cancer by altering the tumor microenvironment

<b>Influência do estrógeno e progesterona na ativação in-vitro da indoleamina 2,3 dioxigenase-IDO- em células presentes no microambiente do carcinoma mamário de cadelas</b>

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