Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy

Henríquez, Ignacio Roa; Cantín, Mario; Vilos, Cristián; Rosas, Carlos; Lemus, David

doi:10.4067/s0717-95022017000200055

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Cabe destacar que se mantiene la ausencia de diferencia significativa entre Cx+PLGA y Cx, al hecho que la cantidad de Cx necesaria es mucho menor y que en ambos casos se logra un efecto permanente a las 96 horas. Esto no confirma que el efecto se mantenga posterior a las 96 horas y, por lo tanto, es probable que las diferencias se manifiesten posterior a este tiempo y por lo tanto es necesario comprobar rol de PLGA en cuanto a la disponibilidad y liberación del fármaco cuando se administra microencapsulado en comparación a Cx no encapsulado (Roa et al, 2016(Roa et al, , 2017.…”

Section: Discussionunclassified

Efecto Angiogénico Comparado del Celecoxib Microencapsulado en PLGA v/s no Encapsulado En un Ensayo in vivo de Angiogénesis

et al. 2022

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Section: Discussionunclassified

Efecto Angiogénico Comparado del Celecoxib Microencapsulado en PLGA v/s no Encapsulado En un Ensayo in vivo de Angiogénesis

et al. 2022

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“…Experimental studies indicate that the administration of Celecoxib at a concentration of 1000 ppm decreases microvascular density, also reducing the presence of VEGF in multidrug-resistant TA3 tumor cells, which would make it a good candidate for use alone, or in combination with other anti-tumor molecules, ideally with the aim of obtaining synergistic effects (Rosas et al, 2014). For their part, Roa et al (2017) indicate that the CX/PLGA association inhibits microvascularization, VEGF expression at the tumor level, as well as cell proliferation and increased apoptosis. On the other hand, it has been shown that Celecoxib reduces serum levels of VEGF and COX-2 (Han et al, 2014), which would explain the decrease in vascularization, knowing that VEGF is the most critical factor associated with vasculogenesis, angiogenesis and lymphangiogenesis, VEGF-A being an essential regulator of angiogenesis, acting mainly by promoting cell division and migration in endothelial cells (Oklu et al, 2010).…”

Section: Mechanism Of Celecoxib In Tumor Angiogenesismentioning

confidence: 99%

Celecoxib: Antiangiogenic and Antitumoral Action

Rojas,

Roa

2024

Int. J. Morphol.

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Angiogenesis, a process by which new blood vessels are generated from pre-existing ones, is significantly compromised in tumor development, given that due to the nutritional need of tumor cells, pro-angiogenic signals will be generated to promote this process and thus receive the oxygen and nutrients necessary for its development, in addition to being a key escape route for tumor spread. Although there is currently an increase in the number of studies of various anti-angiogenic therapies that help reduce tumor progression, it is necessary to conduct a review of existing studies of therapeutic alternatives to demonstrate their importance.

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Phytochemical Evaluation and Anti-angiogenic Activity of Alingatong (Dendrocnide meyeniana Walp.) Root Extracts Using the Chorioallantoic Membrane Assay on Duck Embryo

Torno,

Subebe,

Manting

et al. 2024

MAB

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Dendrocnide meyeniana (Walp.), known as "Alingatong" in the Visayas region of the Philippines, is a plant from the Urticaceae family. It is commonly found in the mountain areas of Taiwan and the Philippines. This study aims to determine the Dendrocnide meyeniana root extract's anti-angiogenic activity. The methanolic extracts of Dendrocnide meyeniana were subjected to preliminary phytochemical screening. Cytotoxicity test using Brine Shrimp Lethality Assay was conducted with different plant concentrations to determine the concentration to use for the anti-angiogenic activity of the root extracts. The anti-angiogenic activity was observed by calculating blood vessel percent inhibition using chorioallantoic membrane assay or CAM assay. Phytochemical screening reveals that the plant contains varying levels of detection of bioactive compounds, including saponins, flavonoids, alkaloids, and steroids. Brine Shrimp Lethality Assay showed that the ethyl acetate and hexane extracts from Dendrocnide meyeniana were highly toxic as their LC50 values were lower than 100 ppm. CAM assay results showed that hexane with 250 ppm concentration has the highest percent inhibition with 34.98% followed by hexane at 125 ppm with 34.07% inhibition. Both concentrations of ethyl acetate showed low percentage inhibition, where 250 ppm was at 19.05% and 125 ppm at 15.93%. One-way ANOVA indicates that the different treatments have significant differences (p-value< 0.0001) in the number of branches present using the CAM assay. Therefore, based on the results, Dendrocnide meyeniana root extracts have anti-angiogenic properties and these findings will help to understand the efficacy of the traditional medicine used by the local people.

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Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy

Cited by 3 publications

References 27 publications

Efecto Angiogénico Comparado del Celecoxib Microencapsulado en PLGA v/s no Encapsulado En un Ensayo in vivo de Angiogénesis

Efecto Angiogénico Comparado del Celecoxib Microencapsulado en PLGA v/s no Encapsulado En un Ensayo in vivo de Angiogénesis

Celecoxib: Antiangiogenic and Antitumoral Action

Phytochemical Evaluation and Anti-angiogenic Activity of Alingatong (Dendrocnide meyeniana Walp.) Root Extracts Using the Chorioallantoic Membrane Assay on Duck Embryo

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