Angiogenesis and Re-endothelialization in decellularized scaffolds: Recent advances and current challenges in tissue engineering

Mazloomnejad, Radman; Babajani, Amirhesam; Kasravi, Mohammadreza; Ahmadi, Armin; Shariatzadeh, Siavash; Bahrami, Soheyl; Niknejad, Hassan

doi:10.3389/fbioe.2023.1103727

Cited by 15 publications

(8 citation statements)

References 199 publications

(324 reference statements)

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“…There should be more efforts to preserve ECM structure and endothelialization (e.g., physical, enzymatic, and chemical means), as research has shown that variations in the microstructure and quantity of ECM components (e.g., GAGs, elastin, and fibronectin) might affect re-endothelialization. The density of the target organ, its fat content and thickness, the type of decellularization agent, their concentration, solution pH, temperature, and decellularization duration should all be taken into account throughout the decellularization process ( Mazloomnejad et al, 2023 ).…”

Section: Challenges Limitations and Future Prospects Of Using Decellu...mentioning

confidence: 99%

Nerve regeneration using decellularized tissues: challenges and opportunities

Mahdian,

Tabatabai,

Abpeikar

et al. 2023

Front. Neurosci.

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In tissue engineering, the decellularization of organs and tissues as a biological scaffold plays a critical role in the repair of neurodegenerative diseases. Various protocols for cell removal can distinguish the effects of treatment ability, tissue structure, and extracellular matrix (ECM) ability. Despite considerable progress in nerve regeneration and functional recovery, the slow regeneration and recovery potential of the central nervous system (CNS) remains a challenge. The success of neural tissue engineering is primarily influenced by composition, microstructure, and mechanical properties. The primary objective of restorative techniques is to guide existing axons properly toward the distal end of the damaged nerve and the target organs. However, due to the limitations of nerve autografts, researchers are seeking alternative methods with high therapeutic efficiency and without the limitations of autograft transplantation. Decellularization scaffolds, due to their lack of immunogenicity and the preservation of essential factors in the ECM and high angiogenic ability, provide a suitable three-dimensional (3D) substrate for the adhesion and growth of axons being repaired toward the target organs. This study focuses on mentioning the types of scaffolds used in nerve regeneration, and the methods of tissue decellularization, and specifically explores the use of decellularized nerve tissues (DNT) for nerve transplantation.

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Section: Challenges Limitations and Future Prospects Of Using Decellu...mentioning

confidence: 99%

Nerve regeneration using decellularized tissues: challenges and opportunities

Mahdian,

Tabatabai,

Abpeikar

et al. 2023

Front. Neurosci.

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“…Biomaterial scaffolds can be used as a solution to counter ECM impairment or loss ( Chio et al, 2022 ). Strategies that use ECM-based biomaterials and combination of cell-derived ECM with synthetic scaffolds have potential to promote tissue repair ( Hong et al, 2020 ; Mazloomnejad et al, 2023 ). Using combination of biomaterials with cell-based strategies promote nerve injury repair by mimicking the physical and chemical properties of the normal ECM and offering the correct position of neural cell location and ECM deposition ( Poongodi et al, 2021 ).…”

Section: Pathophysiological Mechanisms Following Spinal Cord Injurymentioning

confidence: 99%

Hydrogel-encapsulated extracellular vesicles for the regeneration of spinal cord injury

Nazerian,

Mohamadi-Jahani

et al. 2023

Front. Neurosci.

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Spinal cord injury (SCI) is a critical neurological condition that may impair motor, sensory, and autonomous functions. At the cellular level, inflammation, impairment of axonal regeneration, and neuronal death are responsible for SCI-related complications. Regarding the high mortality and morbidity rates associated with SCI, there is a need for effective treatment. Despite advances in SCI repair, an optimal treatment for complete recovery after SCI has not been found so far. Therefore, an effective strategy is needed to promote neuronal regeneration and repair after SCI. In recent years, regenerative treatments have become a potential option for achieving improved functional recovery after SCI by promoting the growth of new neurons, protecting surviving neurons, and preventing additional damage to the spinal cord. Transplantation of cells and cells-derived extracellular vesicles (EVs) can be effective for SCI recovery. However, there are some limitations and challenges related to cell-based strategies. Ethical concerns and limited efficacy due to the low survival rate, immune rejection, and tumor formation are limitations of cell-based therapies. Using EVs is a helpful strategy to overcome these limitations. It should be considered that short half-life, poor accumulation, rapid clearance, and difficulty in targeting specific tissues are limitations of EVs-based therapies. Hydrogel-encapsulated exosomes have overcome these limitations by enhancing the efficacy of exosomes through maintaining their bioactivity, protecting EVs from rapid clearance, and facilitating the sustained release of EVs at the target site. These hydrogel-encapsulated EVs can promote neuroregeneration through improving functional recovery, reducing inflammation, and enhancing neuronal regeneration after SCI. This review aims to provide an overview of the current research status, challenges, and future clinical opportunities of hydrogel-encapsulated EVs in the treatment of SCI.

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“…It is longitudinal mainly in design, and they have broad applications and potential for use in clinical research. Multi-omics approaches have been applied in various elds, including cardiovascular diseases, autoimmune diseases, pregnancy and obstetrics, and cancers (24)(25)(26)(27). Several integration approaches, including conceptual, statistical, and model-based, have been used to integrate omics data and gain biological insight.…”

Section: Multi-omics Data Integration For Upper Gi Cancersmentioning

confidence: 99%

Multi-omics data integration in upper gastrointestinal cancers research: A review of concepts, approaches, and application

Mazloomnejad

Ahmadi

Piroozkhah

et al. 2023

Preprint

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Upper gastrointestinal (GI) cancers, including esophageal, gastric, liver, and pancreatic cancers, are a major medical and economic burden worldwide. Despite significant advances in radiotherapy, chemotherapy, and targeted treatments for upper GI cancers in the past decade, a high recurrence rate and poor prognosis are still challenging in upper GI cancer management. This trouble is rooted in the current diagnosis methods and the lack of adequate and reliable diagnostic/prognostic biomarkers. The diagnosis of almost every disease of the upper GI tract still depends on invasive investigations such as endoscopy of the upper GI tract, manometry of the stomach and esophagus, or radiography. Although cancer was considered a single disease in the organ of origin in the past, today, it is accepted that cancer is a heterogeneous disease assuming the same organ of origin. Therefore, to conduct precision/personalized medicine, it seems necessary to have suitable biomarkers to make an accurate diagnosis, appropriate patient classification, prognosis assessment, and drug response in cancers. Systems biology and multi-omics research are strategies adopted to provide genetic and molecular biomarkers in cancer. Toward studying complex biological processes, multi-omics data analysis provides an opportunity to gain a deeper and more comprehensive understanding of cancer development and progression. Multi-omics approaches are new frameworks that integrate omics datasets, including genome, epigenome, transcriptome, proteome, metabolome, and metagenome, on the same set of samples to understand cancer's molecular and clinical characteristics better. Therefore, in this review, we focus on the integrated multi-omics studies conducted on esophageal, gastric, liver, and pancreatic cancers and discuss the results regarding diagnostic and prognostic biomarkers, as well as biomarkers that determine the response to treatment.

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Angiogenesis and Re-endothelialization in decellularized scaffolds: Recent advances and current challenges in tissue engineering

Cited by 15 publications

References 199 publications

Nerve regeneration using decellularized tissues: challenges and opportunities

Nerve regeneration using decellularized tissues: challenges and opportunities

Hydrogel-encapsulated extracellular vesicles for the regeneration of spinal cord injury

Multi-omics data integration in upper gastrointestinal cancers research: A review of concepts, approaches, and application

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