Angiogenesis and Osteogenesis at Incorporation Process of Onlay Bone Graft

Moreira, David Costa; Sá, Camila Neves; Andrade, Miguel Gustavo Setúbal; Bittencourt, Thereza Cristina Borio dos Santos Calmon de; Reis, Sílvia Regina de Almeida; Pithon, Matheus Melo; Sadigursky, Moysés

doi:10.1016/j.joms.2013.06.215

Cited by 14 publications

(10 citation statements)

References 24 publications

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“…They showed that FGF-2 had superior pro-angiogenic effects in neoangiogenesis process at the recipient site compared with VEGF ( 40 ). Moreira et al indicated that onlay grafts, which included autogenous and allogenic bone grafts in combination with platelet-rich plasma (PRP) as a modifier, promoted the angiogenesis and osteogenesis events in rabbit mandibles ( 41 ) ( Table 1 and Table 1continue ).…”

Section: Discussionmentioning

confidence: 99%

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The role of angiogenesis in implant dentistry part II: The effect of bone-grafting and barrier membrane materials on angiogenesis

2016

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BackgroundIn implant dentistry, bone substitute materials and barrier membranes are used in different treatments including guided bone regeneration (GBR), socket preservation, alveolar ridge augmentation, maxillary sinus elevation, and filling bony defects around the inserted dental implant. One of the most important factors in prognosis of treatments using these materials is the growth of new blood vessels in applied areas. Present review was performed to evaluate the effect of the bone-grafting and barrier membrane materials on angiogenesis events.Material and MethodsAn electronic search was performed in PubMed, MEDLINE, and EMBASE databases via OVID using the keywords mentioned in the PubMed and MeSH headings regarding the role of angiogenesis in implant dentistry from January 2000-April 2014.ResultsOf the 5,622 articles identified in our initial search results, only 33 met the inclusion criteria set for this review. Among bone substitute materials the autogenous bone-grafts, and among the barrier membranes the collagenous membranes, had the highest angiogenic potentials. Other bone-grafting materials or membranes were mostly used with pro-angiogenic factors to enhance their angiogenic properties.ConclusionsAngiogenesis is one of the key factors, which plays a critical role in success rate of GBR technique and is seriously considered in manufacturing bone-grafting and barrier membrane materials. However, there is still lack of clinical and in-vivo studies addressing the effect of angiogenesis in treatments using bone-grafting and barrier membrane materials. Key words:Angiogenesis, bone-grafting materials, GBR, ridge augmentation, sinus elevation, socket preservation.

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Section: Discussionmentioning

confidence: 99%

“…Angiogenesis plays a significant role in osteoblast differentiation and bone matrix formation at grafted sites ( 41 ). Nevins, Reynolds showed that platelet derived growth factor-BB (PDGF-BB) in combination with allograft bone materials can be used for bone regeneration at implant sites ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

The role of angiogenesis in implant dentistry part II: The effect of bone-grafting and barrier membrane materials on angiogenesis

2016

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“…Contrary to the negative results of one study on rabbits [198], PRP can induce angiogenesis and bone formation [202,203]. PRP induces angiogenesis both in vitro and in vivo and may result from the activation of the ERK and phosphatidylinositol-3-kinase-Akt pathways [10].…”

Section: Animal: Improvementmentioning

confidence: 93%

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Kuffler

2015

Mol Neurobiol

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Platelet-rich plasma (PRP) has been tested in vitro, in animal models, and clinically for its efficacy in enhancing the rate of wound healing, reducing pain associated with injuries, and promoting axon regeneration. Although extensive data indicate that PRP-released factors induce these effects, the claims are often weakened because many studies were not rigorous or controlled, the data were limited, and other studies yielded contrary results. Critical to assessing whether PRP is effective are the large number of variables in these studies, including the method of PRP preparation, which influences the composition of PRP; type of application; type of wounds; target tissues; and diverse animal models and clinical studies. All these variables raise the question of whether one can anticipate consistent influences and raise the possibility that most of the results are correct under the circumstances where PRP was tested. This review examines evidence on the potential influences of PRP and whether PRP-released factors could induce the reported influences and concludes that the preponderance of evidence suggests that PRP has the capacity to induce all the claimed influences, although this position cannot be definitively argued. Well-defined and rigorously controlled studies of the potential influences of PRP are required in which PRP is isolated and applied using consistent techniques, protocols, and models. Finally, it is concluded that, because of the purported benefits of PRP administration and the lack of adverse events, further animal and clinical studies should be performed to explore the potential influences of PRP.

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“…Regardless of the nature of the material, it is necessary to have angiogenesis in order to integrate it into the receptor bed and to maintain its volume. This ensures the presence and proliferation of preosteoblasts [ 1 ]. When preosteoblasts differentiate into osteoblasts, they contribute to a much more intense lamellar bone formation around the bone substitute particles.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study

Anghelescu

Neculae

Dincă

et al. 2018

Journal of Immunology Research

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Introduction The clinical use of bioactive materials for bone augmentation has remained a challenge because of predictability and effectiveness concerns, as well as increased costs. The purpose of this study was to analyse the ability to integrate bone substitutes by evaluating the immunohistochemical expression of the platelet endothelial cell adhesion molecules, vascular endothelial growth factor, collagen IV, laminin, and osteonectin, in the vicinity of bone grafts, enabling tissue revascularization and appearance of bone lamellae. There is a lack of in vivo studies of inflammatory-driven angiogenesis in bone engineering using various grafts. Methods The study was performed in animal experimental model on the standardized monocortical defects in the tibia of 20 New Zealand rabbits. The defects were augmented with three types of bone substituents. The used bone substituents were beta-tricalcium phosphate, bovine hydroxyapatite, and bioactive glasses. After a period of 6 months, bone fragments were harvested for histopathologic examination. Endothelial cell analysis was done by analysing vascularization with PECAM/CD31 and VEGF and fibrosis with collagen IV, laminin, and osteonectin stains. Statistical analysis was realized by descriptive analysis which was completed with the kurtosis and skewness as well as the Kruskal-Wallis and Mann-Whitney statistical tests. Results The discoveries show that the amount of bone that is formed around beta-tricalcium phosphate and bovine hydroxyapatite is clearly superior to the bioactive glasses. Both the lumen diameter and the number of vessels were slightly increased in favor of beta-tricalcium phosphate. Conclusion We can conclude that bone substitutes as bovine bone and beta-tricalcium phosphate have significant increased angiogenesis (and subsequent improved osteogenesis) compared to the bioactive glass. In our study, significant angiogenesis is linked with a greater tissue formation, indicating that in bone engineering with the allografts we used, inflammation has more benefic effects, the catabolic action being exceeded by the tissue formation.

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Angiogenesis and Osteogenesis at Incorporation Process of Onlay Bone Graft

Cited by 14 publications

References 24 publications

The role of angiogenesis in implant dentistry part II: The effect of bone-grafting and barrier membrane materials on angiogenesis

The role of angiogenesis in implant dentistry part II: The effect of bone-grafting and barrier membrane materials on angiogenesis

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study

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