Angiogenesis and new bone formation in novel unidirectional porous beta-tricalcium phosphate: a histological study

Kumagai, Hiroshi; Makihara, Takeshi; Funayama, Toru; Sato, Kosuke; Noguchi, Hiroshi; Abe, Tetsuya; Koda, Masao; Yamazaki, Masashi

doi:10.1007/s10047-019-01120-8

Cited by 13 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some synthetic bone substitutes through mimicking the structure, properties, and function of natural bone have been used as feasible alternatives to support the subchondral bone of femoral head, and to avoid donorsite morbidity [13]. Characterized by easy biodegradation and high osteoconduction [14], beta-tricalcium phosphate (β-TCP) is used to refill the bone defect and provide initial mechanical support for ONFH in clinical practice [15].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: High failure rate after Beta-tricalcium phosphate grafting for the treatment of femoral head osteonecrosis: a retrospective analysis

Liu

et al. 2020

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background: Non-vascularized bone grafting is a promising head-preserving technique for younger patients diagnosed as non-traumatic osteonecrosis of the femoral head (NONFH). Among the various types of bone grafting techniques, "light-bulb" procedure grafting with synthetic bone substitute is an attractive option. We aimed to assess the effectiveness of using beta-tricalcium phosphate (β-TCP) for the treatment of pre-collapse and early postcollapse lesions NONFH. Methods: From April 2010 to June 2014, 33 patients (47 hips) with NONFH were treated using the afore-mentioned technique. The clinical and radiological outcomes were recorded and compared statistically between pre-and postoperation. Harris hip score (HHS) was used to evaluate the clinical results, and Association Research Circulation Osseous (ARCO) stage was applied to assess the radiological outcomes. Results: The 5-years survival rate of using β-TCP grafting was accounting for 25.5%. HHS was decreased from 78.47 to 52.87 points, and a very significant worsening of radiological results were revealed (P < 0.05). Two hips collapsed more than 2 mm were awaiting for THA, and 33 of the 47 hips had converted to THAs in an average time to failure of 24.24 months postoperatively. Meanwhile, only 4 hips survived without collapse, and 8 hips collapsed less than 2 mm. After surgery, the time onset of head collapse was 3.65 months on average, and the first conversion to THA was performed at 5 months postoperative. Conclusions: Our results suggest that "light-bulb" procedure grafting with β-TCP sticks presented with a high failure rate in the early postoperative period. It is not proposed for the treatment of pre-collapse and early postcollapse lesions NONFH.

show abstract

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: High failure rate after Beta-tricalcium phosphate grafting for the treatment of femoral head osteonecrosis: a retrospective analysis

Liu

et al. 2020

BMC Musculoskelet Disord

View full text Add to dashboard Cite

show abstract

“…After limpidity of the fluid from vena cava, contrast agent (Microfil MV-122 [yellow]; Flow Tech, USA) was injected in the aorta according to the manufacturer’s protocol ( Fig. 5B ) [ 33 ]. The animals were then euthanasia and stored at 4°C overnight.…”

Section: Methodsmentioning

confidence: 99%

Integrating pore architectures to evaluate vascularization efficacy in silicate-based bioceramic scaffolds

Yang

et al. 2021

Regenerative Biomaterials

View full text Add to dashboard Cite

Pore architecture in bioceramic scaffolds plays an important role in facilitating vascularization efficiency during bone repair or orbital reconstruction. Many investigations have explored this relationship but lack integrating pore architectural features in a scaffold, hindering optimization of architectural parameters (geometry, size, curvature) to improve vascularization and consequently clinical outcomes. To address this challenge, we have developed an integrating design strategy to fabricate different pore architectures (cube, gyroid, hexagon) with different pore dimensions (∼350, 500, 650 μm) in the silicate-based bioceramic scaffolds via digital light processing technique. The sintered scaffolds maintained high-fidelity pore architectures similar to the printing model. The hexagon- and gyroid-pore scaffolds exhibited the highest and lowest compressive strength (from 15 to 55 MPa), respectively, but the cube-pore scaffolds showed appreciable elastic modulus. Moreover, the gyroid pore architecture contributed on a faster ion dissolution and mass decay in vitro. It is interesting that both μCT and histological analyses indicate vascularization efficiency was challenged even in the 650-μm pore region of hexagon-pore scaffolds within 2 weeks in rabbit models, but the gyroid pore constructs indicated appreciable blood vessel networks even in the 350-μm pore region at 2 weeks and high-density blood vessels were uniformly invaded in the 500- and 650-μm pore at 4 weeks. Angiogenesis was facilitated in the cube-pore scaffolds in comparison with the hexagon-pore ones within 4 weeks. These studies demonstrate that the continuous pore wall curvature feature in gyroid pore architecture is an important implication for biodegradation, vascular cell migration and vessel ingrowth in porous bioceramic scaffolds.

show abstract

“…Replacement with host bone was evident in the cortical bone area, while material resorption and remodeling progressed in the medullary cavity [ 7 ]. In the same experimental model, histological assessment of the material after injecting dye into the blood vessels 6 weeks after implantation detected the presence of dye along with new bone formation within the material, confirming angiogenesis and the presence of blood flow [ 9 ]. Additionally, in an experiment conducted in beagle dogs where grafting was performed in a femoral bony defect, the entire 10-mm-long material was filled with new bone matching the porous direction at 3 months [ 10 ].…”

Section: Animal Experiments During the Development Of Affinos ® Unidirectional Porous β-Tcpmentioning

confidence: 99%

Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications

et al. 2021

Self Cite

View full text Add to dashboard Cite

In Japan, where allograft bone transplantation is not widespread, prospects for artificial bones are very high. Therefore, artificial bones with various compositions, porous structures, and porosities have been developed and employed for clinical use. Both Affinos® and Regenos® (made of beta-tricalcium phosphate and hydroxyapatite, respectively) are artificial bones with a unique unidirectional porous structure, in which pores with a diameter suitable for tissue penetration (25–300 μm) are aligned in one direction. The unidirectional porous structure allows rapid penetration of blood deep into the materials by a capillary effect. In animal experiments, Affinos® showed well-balanced resorption and was replaced with the host’s own bone from an early stage after implantation and new bone formation and remodeling were observed in the cortical bone and medullary cavity. When implanted for clinical situation, resorption from an early stage and good replacement with the patient’s own bone were also observed. Regenos® has an internal osteon-like material and a vascular-like structure that is maintained within the pores even after long-term implantation, as noted in an animal experiment. When implanted for clinical situation, good osteoconductivity was observed from an early stage of implantation. In addition, the material was observed to be slowly absorbed over time in some cases. We have discussed the beneficial effects of combining teriparatide and platelet-rich plasma impregnation and the potential prospects of these artificial bones.

show abstract

Angiogenesis and new bone formation in novel unidirectional porous beta-tricalcium phosphate: a histological study

Cited by 13 publications

References 18 publications

RETRACTED ARTICLE: High failure rate after Beta-tricalcium phosphate grafting for the treatment of femoral head osteonecrosis: a retrospective analysis

RETRACTED ARTICLE: High failure rate after Beta-tricalcium phosphate grafting for the treatment of femoral head osteonecrosis: a retrospective analysis

Integrating pore architectures to evaluate vascularization efficacy in silicate-based bioceramic scaffolds

Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications

Contact Info

Product

Resources

About