Angiogenesis and hypertension

Noble, F.A.C. le; Stassen, Frank R. M.; Hacking, Wim J.G.; Boudier, H. A. J. Struijker

doi:10.1097/00004872-199816110-00001

Cited by 98 publications

(65 citation statements)

References 72 publications

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“…These data are consistent with the observation of structural alterations of the microvascular bed in hypertension. 28 Moreover, hypertension was shown to be associated with a profound downregulation of tissue hepatocyte growth factor, which is an essential endothelial growth factor. 29,30 Thus, a paracrine effect induced by increased angiotensin II levels in hypertensive patients could potentially be involved in the regulation of EPC migration.…”

Section: Vasa Et Al Risk Factors and Endothelial Progenitor Cellsmentioning

confidence: 99%

Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease

Vasa

Fichtlscherer

Aicher

et al. 2001

Circulation Research

2,138

1,803

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Section: Vasa Et Al Risk Factors and Endothelial Progenitor Cellsmentioning

confidence: 99%

Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease

Vasa

Fichtlscherer

Aicher

et al. 2001

Circulation Research

2,138

1,803

View full text Add to dashboard Cite

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mentioning

confidence: 99%

“…First, the angiogenic capacity of serum derived from SHR was less than that from normotensive animals in a chick embryo chorio-allantoic membrane model. 13 Protein levels of key proangiogenic growth factors such as vascular endothelial growth factor (VEGF) and hepatocyte growth factor are also reduced in hypertensive animals. 11,14 Second, previous obser-vations that endothelial function is impaired in SHR as well as in patients with essential hypertension imply that the defective endothelial function may contribute to impaired angiogenesis in SHR.…”

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confidence: 99%

Hypertension Impairs Postnatal Vasculogenesis

et al. 2008

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Key Words: hypertension Ⅲ angiogenesis Ⅲ progenitor cells Ⅲ angiotensin converting enzyme Ⅲ angiotensin type I receptor T he revascularization process, including vasculogenesis, angiogenesis, and collateral growth, characterizes tissue repair and remodeling occurring in acute and chronic ischemic vascular diseases. In particular, postnatal vasculogenesis referred to the homing and differentiation of circulating progenitor cells from bone marrow or non-bone marrow origins 1 into endothelial cells within sites of active neovascularization. In addition, circulating progenitor cells may deliver angiogenic growth factors to pathological tissues and contribute to neovascularization and tissue/vessel remodeling by paracrine effects. 2,3 In most clinical settings, however, these natural adaptive responses to a compromised perfusion are insufficient to block the progression of ischemic diseases. Hence, certain cardiovascular risk factors including diabetes, aging, and hypercholesterolemia adversely affect postnatal vasculogenesis and revascularization in animals models of limb ischemia. 4 -7 In support of this view, patients with type I and II diabetes displayed a reduction in endothelial progenitor cell (EPC) number and angiogenicity. 8,9 In most forms of clinical and experimental hypertension, increased arterial blood pressure is associated with microvascular rarefaction and increased peripheral vascular resistances. 10 Similarly, postischemic reparative neovascularization is impaired in spontaneously hypertensive rats (SHR) as a function of progression of the hypertensive disease. 11,12 Several molecular and cellular mechanisms may be involved in the hypertension-induced impairment in vessel growth. First, the angiogenic capacity of serum derived from SHR was less than that from normotensive animals in a chick embryo chorio-allantoic membrane model. 13 Protein levels of key proangiogenic growth factors such as vascular endothelial growth factor (VEGF) and hepatocyte growth factor are also reduced in hypertensive animals. 11,14 Second, previous obser-

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“…21 On the other hand, abnormal angiogenesis has been demonstrated in hypertension. 22,23 Previous studies have demonstrated that hypertensive patients exhibit elevated plasma levels of Ang-1 and Ang-2. 5 Moreover, abnormal indices of angiogenesis in hypertension are correlated with target organ damage 6 and cardiovascular outcome.…”

Section: Discussionmentioning

confidence: 99%

Arterial stiffness in hypertensives in relation to expression of angiopoietin-1 and 2 genes in peripheral monocytes

et al. 2010

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Angiopoietins (Angs) are important angiogenic and endothelial cell growth factors with many functions, including influence on the vascular wall. Pulse-wave velocity (pwv) is an independent marker of cardiovascular adverse outcome in hypertensives, although all the pathophysiological mechanisms that affect it have not yet been determined. We investigated the relationship between arterial stiffness and Ang-1 and Ang-2 gene expression in the peripheral blood monocytes of hypertensive patients. We studied 53 patients who had untreated grade-1 or grade-2 essential hypertension and no indications of other organic heart disease. Carotid-femoral (c-f) and carotid-radial (c-r) artery waveforms were measured and pwv was determined. The monocytes were isolated using anti-CD14 þ antibodies and mRNAs were estimated by real-time quantitative reverse transcription-PCR. Ang-1 gene expression was strongly correlated with both c-f-pwv (r ¼ 0.952, Po0.001) and c-r-pwv (r ¼ 0.898, Po0.001). Similarly, Ang-2 gene expression was significantly correlated with both c-f-pwv (r ¼ 0.471, P ¼ 0.002) and c-r-pwv (r ¼ 0.437, P ¼ 0.003). Our data provide important evidence that Ang-1 and Ang-2 gene expression levels in peripheral monocytes are closely related with pwv in patients with essential hypertension. This positive correlation may suggest a link between angiogenesis and arterial stiffness in those patients.

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Angiogenesis and hypertension

Abstract: Genetic and fetal influences appear to have significant effects in determining impaired vascular development as an early cause of essential hypertension.

Cited by 98 publications

References 72 publications

Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease

Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease

Hypertension Impairs Postnatal Vasculogenesis

Arterial stiffness in hypertensives in relation to expression of angiopoietin-1 and 2 genes in peripheral monocytes

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