Angiogenesis and Ewing sarcoma—relationship to pulmonary metastasis and survival

Mikulić, Danko; Ilić, Ivana; Ćepulić, Mladen; Giljević, Jasminka Stepan; Orlić, Dubravko; Źupančić, Boidar; Fattorini, Ivan; Seiwerth, Sven

doi:10.1016/j.jpedsurg.2005.11.058

Cited by 8 publications

(6 citation statements)

References 18 publications

(36 reference statements)

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“…One group demonstrated a significant association between elevated (MVD) and poor event-free and overall survival in 29 patients with Ewing sarcoma 25. In contrast, two other groups have reported that tumor MVD does not correlate with metastatic status, disease-free survival, or overall survival 26, 27…”

Section: Markers Of Angiogenesis In Patients With Ewing Sarcomamentioning

confidence: 91%

“…25 In contrast, 2 other groups reported that tumor MVD does not correlate with metastatic status, disease-free survival, or OS. 26,27 Other studies have focused on tumor and blood levels of VEGF, again with conflicting results. One group assessed VEGF expression by immunohistochemistry in 40 patient tumor samples and observed that patients who had tumor VEGF expression above the median level had improved recurrence-free survival and OS compared with patients who had low VEGF expression.…”

Section: Markers Of Angiogenesis In Patients With Ewing Sarcomamentioning

confidence: 99%

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Angiogenesis and vascular targeting in Ewing sarcoma

DuBois

Marina

Bender

2009

Cancer

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Ewing sarcoma is the second most common type of bone cancer in children and young adults. In recent years, the mechanisms by which these tumors develop and maintain their vascular supply have been elucidated. Additional work has demonstrated that inhibition of angiogenic pathways or disruption of established vasculature can attenuate the growth of Ewing sarcoma mouse xenografts. Early clinical data suggest that these results also may extend to patients with Ewing sarcoma who are treated with antiangiogenic or antivascular therapies. For the current review, the authors summarized the available data supporting this approach. Cancer 2010. © 2009 American Cancer Society.

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Section: Markers Of Angiogenesis In Patients With Ewing Sarcomamentioning

confidence: 91%

Section: Markers Of Angiogenesis In Patients With Ewing Sarcomamentioning

confidence: 99%

Angiogenesis and vascular targeting in Ewing sarcoma

DuBois

Marina

Bender

2009

Cancer

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“…This increase in microvascular density is not age-related. 10 In a study by Mikulić et al, 11 the increased microvascular density of ES also did not correlate with outcome, although the microvascular density of OS was higher than that of ES. 9,11…”

Section: Discussionmentioning

confidence: 90%

Dynamic Contrast-enhanced Magnetic Resonance Imaging Scan in Osteosarcoma and Ewing Sarcoma

Albtoush¹,

Al‐Hussaini²,

Yaser³

et al. 2018

Hong Kong J Radiol

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Objective: To compare the initial enhancement patterns in patients with osteosarcoma and Ewing sarcoma. Methods: Patients diagnosed with osteosarcoma and Ewing sarcoma between June 2013 and July 2014 were included. Patients received dynamic contrast-enhanced magnetic resonance imaging scans in order to determine the initiation of enhancement time and the enhancement curve. Results: In total, 19 of 21 (90%) patients with osteosarcoma showed earlier initiation of enhancement compared with five of 20 (25%) patients with Ewing sarcoma. Conclusion: Patients with osteosarcoma showed more initial hypervascularity than did those with Ewing sarcoma, manifested by considerable differences in the percentage with early initiation of enhancement in the dynamic analysis.

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“…Lung metastasis in patients with ES can be affected by multiple risk factors [ 11 , 15 , 21 , 22 , 23 ]. Pathways related to platelet-derived growth factor (PDGF) signaling, Wnt signaling, apoptosis signaling, TP53, Notch signaling, and angiogenesis have been found to be of importance for the occurrence and development of metastasis in ES.…”

Section: Discussionmentioning

confidence: 99%

Lung Metastasis Probability in Ewing Sarcoma: A Nomogram Based on the SEER Database

2020

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Background. Up to now, an accurate nomogram to predict the lung metastasis probability in Ewing sarcoma (ES) at initial diagnosis is lacking. Our objective was to construct and validate a nomogram for the prediction of lung metastasis in ES patients. Methods. A total of 1157 patients with ES from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively collected. The predictors of lung metastasis were identified via the least absolute shrinkage and selection operator (LASSO) and multivariate logistic analysis. The discrimination and calibration of the nomogram were validated by receiver operating characteristic (ROC) curve and calibration curve. Decision curve analysis (DCA) was used to evaluate the clinical usefulness and net benefits of the prediction model. Results. Factors including age, tumor size, primary site, tumor extension, and other site metastasis were identified as the ultimate predictors for the nomogram. The calibration curves for the training and validation cohorts both revealed good agreement, and the Hosmer–Lemeshow test identified that the model was well fitted (p > 0.05). In addition, the area under the ROC curve (AUC) values in the training and validation cohorts were 0.732 (95% confidence interval, CI: 0.607–0.808) and 0.741 (95% CI: 0.602–0.856), respectively, indicating good predictive discrimination. The DCA showed that when the predictive metastasis probability was between 1% and 90%, the nomogram could provide clinical usefulness and net benefit. Conclusion. The nomogram constructed and validated by us could provide a convenient and effective tool for clinicians that can improve prediction of the probability of lung metastasis in patients with ES at initial diagnosis.

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Angiogenesis and Ewing sarcoma—relationship to pulmonary metastasis and survival

Cited by 8 publications

References 18 publications

Angiogenesis and vascular targeting in Ewing sarcoma

Angiogenesis and vascular targeting in Ewing sarcoma

Dynamic Contrast-enhanced Magnetic Resonance Imaging Scan in Osteosarcoma and Ewing Sarcoma

Lung Metastasis Probability in Ewing Sarcoma: A Nomogram Based on the SEER Database

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