Angiofollicular lymph node hyperplasia (Castleman)

Abstract

Six personally observed cases of this lesion are reported and the literature is reviewed. One hundred and thirty-four cases have been reported to date. The lesion has occurred in many sites, but is commonest in the thorax (60%), abdomen (11%), neck (14%), and axilla (4%).Ninety per cent of cases are symptomless or have only the pressure symptoms, 10% have systemic signs, namely, fever, raised ESR, anaemia, cured by removal of the tumour. These cases have a slightly different histology. All recorded cases have been benign. Microscopically the lesion is follicular but instead of germinal centres the follicles have one or more thick-walled arteries and often some surrounding histiocytes. Increased numbers of vessels occur between the follicles, whilst sinuses are absent. These vessels have thick, cellular walls like post-capillary venules. Sometimes they become hyaline.The cases with symptoms have true reaction centres as well as a few intrafollicular vessels. Between the follicles there are increased numbers of vessels and, in addition, there may be collections of plasma cells or eosinophils.

Pathology Quiz Case

“…4 It most commonly presents as an incidental solitary mediastinal mass on a radiograph, but it can occur in many extrathoracic sites, including the neck, abdomen, retroperitoneum, pelvis, and axilla. 3,5 In the head and neck, lesions are often closely associated with the sternocleidomastoid muscle, although involvement of the larynx, submandibular region, parapharyngeal region, and retropharynx has been reported. 6,7 Histologically, the hyaline vascular type of CD is characterized by the proliferation of morphologically distinct lymphoid follicles that obscure underlying nodal architecture.…”

Doença de castleman simulando neoplasia pancreática

“…Usualmente a DC ocorre em adultos jovens e se apresenta como uma massa mediastinal assintomática ou adenopatia localizada, podendo abranger o tórax (63%), pescoço (14%), abdome (11%) e axila (4%) 2 . Caracteriza-se por ser um raro distúrbio linfoproliferativo, com evolução quase sempre benigna e etiologia desconhecida.…”

Membranoproliferative Glomerulonephritis Associated with Multicentric Angiofollicular Lymph Node Hyperplasia

“…Since then, a number of cases have been reported under various names and locations other than the mediastinum [2], This condition has many synonyms including angiomatous lymphoid hamartomas [3] and giant lymph node hyperplasia of the mediastinum [4] , The etiology is not known but presumed to be infec tious or inflammatory in origin, and the lymph node lesions always behave as a benign tumor [5]. Keller et al [4] analyzed 81 cases and divided the lesions into two types based on definitive clinical and pathological crite ria.…”