Angiofibroma of the Vulva

Ahmadnia, Hassan; Kamalati, Ali; Dolati, Mahmood; Rezayat, Alireza Akhavan; Katebi, Mehrdad

doi:10.2310/7750.2013.13130

Cited by 5 publications

(7 citation statements)

References 9 publications

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“…Outside the vulvo-vaginal region, 5 pelvic localizations are reported, including 4 perineum and an urethral site. Six extra-pelvic CA are reported, such as a left hip, lateral knee, chest wall, left axilla and breasts [ 10 ], left hypocondrium [ 3 , 5 ] and more recently, we have reported the first case of retroperitoneal CA arising in right paravesical space of a post-menopausal woman [ 11 ].…”

Section: Reviewmentioning

confidence: 99%

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Cellular angiofibroma in women: a review of the literature

et al. 2015

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Cellular Angiofibroma (CA) represents a quite recently described mesenchymal tumour that occurs in both genders, in particular in the vulvo-vaginal region in women and in the inguino-scrotal area in men. The first description of this tumour dates from Nucci et al. article in 1997; since then, the literature reports different reviews and case report of this tumour in both genders, but no article specifically addressing CA treatment and follow-up in women. In this review we collected all 79 published female CA cases, analyzing the clinical, pathological and immunohistochemical features of the tumour.CA affects women mostly during the fifth decade of life, it is generally a small and asymptomatic mass that mainly arises in the vulvo-vaginal region, although there are reported pelvic and extra-pelvic cases. The treatment requires a simple local excision due to an extremely low ability to recurrent locally and no chance to metastasize. Throughout the immunohistochemical and pathological findings it is also easily possible a differential diagnosis from the other soft tissue tumours which affect the vulvo-vaginal area, such as spindle cell lipoma, solitary fibrous tumour, angiomyofibroblastoma and aggressive angiomyxoma.

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Section: Reviewmentioning

confidence: 99%

“…Six extra-pelvic CA are reported in literature. Exceptionally, a young woman presented both vulvar and extra-pelvic CA, particularly two vulvar CA on the right and the left labia majora and three extravulvar CA on the left axilla and both breasts were reported [ 10 ].…”

Section: Reviewmentioning

confidence: 99%

Cellular angiofibroma in women: a review of the literature

et al. 2015

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“…Vulvar angiofibroma usually occurs as a small lesion (usually less than 4 cm) with well-circumscribed margins [4]. In our case, the tumor was larger and did not have a well-defined capsule, also, at the distal pole of the tumor, a clear plane of cleavage with the vaginal wall was not found, making the resection difficult at this point and having to remove part of the vaginal mucosa.…”

Section: Discussionmentioning

confidence: 56%

“…It is found most frequently in middle-aged women around the fifth decade [2], however Amadhnia et al reported a case of a 20-year-old woman [4]. It occurs equally in both sexes and most often arises in the inguinoscrotal or vulvovaginal regions, although cases occurring in extragenital locations such as perineum, chest wall and retroperitoneum have also been described [5,6].…”

Section: Discussionmentioning

confidence: 99%

Angiographic Embolization followed by Excision of Large Cellular Angiofibroma of the Vulva

et al. 2019

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Introduction: Cellular angiofibroma is a rare benign mesenchymal tumor, occurring almost exclusively in the superficial soft tissues of the genital region. Some of these lesions presents as large, hypervascularized masses. There are no reports in the literature to date on the challenges of resection of hypervascularized vulvar masses, or of hypervascularized cellular angiofibroma.Materials and methods: We describe a case of a cellular angiofibroma of the vulva and the surgical approach with tumoral vessel embolization and posterior resection.Case: A 47-year-old women was referred to vulvar pathology section of Italian Hospital of Buenos Aires for evaluation of left vulvar mass. A pelvic angiography was performed 5 days prior to surgery. It showed a hypervascularized formation at the level of the left vulva at the expense mainly of branches of the left internal pudendal artery. A complete resection was performed afterwards at our institution. The histopathological diagnosis was compatible with cellular angiofibroma.Conclusion: We consider that surgical planning is essential and has to be performed with a multidisciplinary approach. Angiographic embolization should be taken into account as a valid resource when planning a surgery with a high risk of blood loss in order to decrease morbidity.

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“…[8] The youngest report of vulvar CA was from a 20-year-old patient with additional lesions on the axilla and breast. [9] In addition, the most recent peculiar site is CA of the orbit as described by Hötte et al [10]…”

Section: Discussionmentioning

confidence: 99%

Surgical excision of giant vulvar angiofibroma: A case report and a review of literature

et al. 2022

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Rationale: Cellular angiofibroma (CA) is a rare tumor of the soft tissue classified as a benign fibroblastic/myofibroblastic tumor. Considering this, the literature regarding CA mainly, but not exclusively, comprises single case reports and case series. Here, we report a case of giant CA of the vulva with comprehensive literature review.Patient concerns: We present a case of a massive vulvar CA arising in 53-year-old woman with no notable medical or surgical history. The mass has grown considerably over time, causing pain and difficult urination, defecation, and movement. The patient had normal regular menstrual cycle with no previous contraception use. Vaginal examination exposed a right-sided large tender vulvar mass with normal-looking vagina.Diagnoses: Pelvic magnetic resonance imaging with contrast revealed a large right vulvar heterogeneously enhancing soft tissue mass measuring 13.1 × 10.9 × 10.7 cm expending the left vulva, with internal and peripheral voids resembling feeding vessels. The mass was surgically removed, and subsequent histopathology showed skin-covered dermal-based lesion composed of fibroblast-like bland and spindle cell proliferation with thin-walled blood vessels of various sizes. Immunohistostaining of CD34 and smooth muscle antigen were both positive, while desmin was found to be negative. A diagnosis of vulvar angiofibroma was made based on the clinical scenario, imaging, and histopathology.Interventions: Mass vulvectomy was performed starting with a circumferential incision at the base of the mass and structural dissection to separate the mass from the vulvar wall. The incision was successfully closed, and subcuticular stitches were applied to the skin.Outcomes: The patient's complaints were significantly relieved with no postoperative complications and the patient is being followed regularly in an outpatient setting.Lessons: Due to its extremely benign nature of CA, and the implausible ability of its recurrence, it was decided to surgically excise it. Despite its rarity, it can be readily identified at its earlier stages preventing the vexing and exasperating symptoms accompanied with increased size as mentioned.

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Angiofibroma of the Vulva

Cited by 5 publications

References 9 publications

Cellular angiofibroma in women: a review of the literature

Cellular angiofibroma in women: a review of the literature

Angiographic Embolization followed by Excision of Large Cellular Angiofibroma of the Vulva

Surgical excision of giant vulvar angiofibroma: A case report and a review of literature

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