Angioedema Following the Intravenous Administration of Metoprolol

Angioedema in Renal Transplant Recipients on Sirolimus

“…The associated risk factors were ACEI therapy or African-American patients taking metoprolol [5, 7, 8], which are known to be associated with a higher frequency of angioedema [22,23,24]. All our patients were Caucasians and a factor known to induce angioedema without urticaria – either an associated drug or a triggering factor – was identified for only 9 (75%).…”

Propranolol-induced angioedema in a patient with chronic hepatitis C virus infection

“…Nevertheless, other b-blockers have been associated with angioedema. 11,12 Beta-blocker therapy is known to predispose patients to or adversely affect patients with several allergic or immunologic conditions. The endogenous production of important mediators of anaphylaxis is normally inhibited by b-adrenergic neurohumoral mechanisms operating via intracellular cAMP and is stimulated by a-adrenergic and cholinergic mechanisms.…”

“…In fact, the previously published cases of angioedema associated with b-blockers involved selective b-blockers, specifically atenolol 11 and metoprolol. 12 Both are b 1 -selective adrenergic-receptor antagonists with weak membrane-stabilizing activity and no intrinsic sympathomimetic activity. 24 In these reports, patients had a history of angioedema.…”

“…angioedema related to b-blockers have been reported, and neither involved propranolol. 11,12 Finally, cases of angioedema have been associated with hepatitis C virus (HCV) infection 13 and the use of recombinant interferon alfa-2b. 14 We report the first case of propranololinduced angioedema in a patient being treated with peginterferon Am J Health-Syst Pharm-Vol 67 Jul 15, 2010 alfa-2a and ribavirin for chronic HCV infection.…”

Cutaneous findings related to cardiovascular disorders

“…125 Intravenous metoprolol can cause severe angioedema. 126 Angiotensin converting enzyme (ACE) inhibitors can cause angioedema involving the deeper layers of the skin, subcutaneous tissue, and mucosa; involvement of the oropharyngeal region causes upper respiratory obstruction and can lead to death. 127,128 Erythromelalgia secondary to verapamil for the treatment of cardiac failure and arrhythmia has been reported.…”