Angioedema associated with excessive sweating and sweat allergy

Miyake, Masako; Oiso, Naoki; Ishii, Kaori; Hide, Michihiro; Kawada, Akira

doi:10.1111/1346-8138.13574

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Our patient displayed higher level of the specific IgE against MGL_1304 than all of the patients with CholU described in a previous study . Recently, a case of angioedema involving excessive sweating and marked histamine release in response to MGL_1304 has been reported …”

Section: Discussionsupporting

confidence: 44%

“…10 Recently, a case of angioedema involving excessive sweating and marked histamine release in response to MGL_1304 has been reported. 12 The conventional treatment for CholU is H 1 RA; however, some patients with severe symptoms respond poorly to such treatment. It was proposed that increased doses of H 1 RA, H 2 RA, montelukast and omalizumab should be administrated to such refractory patients.…”

Section: Discussionmentioning

confidence: 99%

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Case of cholinergic urticaria accompanied by anaphylaxis

Iijima¹,

Kazumi²,

Takayama³

et al. 2017

The Journal of Dermatology

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Cholinergic urticaria occasionally occurs in combination with anaphylactic symptoms. However, this has not been widely reported. Herein, we report the case of a 14-year-old Japanese male who was diagnosed with cholinergic urticaria accompanied by anaphylaxis. The patient, who was suffering from atopic dermatitis and bronchial asthma, had developed wheals after exercising or bathing, which would have increased his core body temperature, since summer 2014. He experienced two episodes of severe systemic symptoms and wheal development when he took a bath after eating in December 2014 and the following January. His symptoms included wheezing, numbness of the lips, respiratory distress, blindness and fainting. Laboratory tests revealed the following results: serum IgE level, 7060 IU/mL; titers of specific immunoglobulin E antibodies against Malassezia and MGL_1304, 31.70 UA/mL and 112.5 ng/mL, respectively. A histamine release test against human sweat revealed a class 4 response. Skin prick and intradermal tests against autologous sweat produced immediate-type positive reactions. According to these findings, we diagnosed him with the sweat-hypersensitivity type of cholinergic urticaria accompanied by anaphylaxis. He was successfully treated with lafutidine, a histamine H receptor antagonist, in combination with fexofenadine. It is important for dermatologists to be aware that cholinergic urticaria can progress to anaphylaxis.

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Section: Discussionsupporting

confidence: 44%

Section: Discussionmentioning

confidence: 99%