Angioedema and Fatty Acids

Abstract

Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioedema, suggesting that some other mediators might contribute to the development of angioedema. Fatty acids are an essential fuel and cell component, and act as a mediator in physiological and pathological human diseases. Recent updates of studies revealed that these fatty acids are involved in vascular permeability and vasodilation, in addition to bradykinin and histamine-mediated reactions. This review summarizes each fatty acid’s function and the specific receptor signaling responses in blood vessels, and focuses on the possible pathogenetic role of fatty acids in angioedema.

The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers

“…Among various nutrient factors, fatty acids are a component of the cell membrane and contribute to signal network transduction in the body. Although there are many types of fatty acids with various physiological and pathological actions [7][8][9][10], omega-3 fatty acids, found in fish oil and nuts, have beneficial effects against human diseases and inflammatory responses [11]. In addition to their therapeutic potency [12][13][14], omega-3 fatty acids may also play a role in the development of cutaneous malignancies due to their anti-inflammatory actions [15].…”