Angioedema: A Review of 367 Episodes Presenting to Three Tertiary Care Hospitals

“…Other well-designed studies showed an incidence of 0.2-2.5% (13)(14)(15). Among patients presenting to a hospital with acute angioedema, 39-46% were treated with ACEi (5,16). In a specialised out-patient setting the incidence was found to be 11% (17).…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 94%

“…1) (17). A lump in the throat, drooling, stridor and a hoarse voice or aphonia are possible symptoms, when the airways are involved, signalling a severe situation with the need to act immediately and secure the airway (16,22). Abdominal pain might be a rare and sometimes the only sign of ACEi-induced angioedema, since the swellings can be present solely in the abdominal organs, most often the intestines (29,30).…”

Section: Clinical Presentationmentioning

confidence: 99%

Angiotensin-converting Enzyme Inhibitor-induced Angioedema – A Dangerous New Epidemic

Rasmussen

Mey²,

Bygum³

2014

Acta Derm Venerol

View full text Add to dashboard Cite

Angioedema is a sudden localised and often asymmetric swelling of the skin or mucous membranes caused by transient increased endothelial permeability causing plasma extravasation. In the last decades the incidence of severe angioedema involving the upper airways and even fatal outcome due to asphyxia has increased. This is mainly due to pharmaceuticals such as angiotensin converting enzyme-inhibitors, which are extensively used worldwide. Some aspects of the pathophysiology have been elucidated and the vasoactive molecule bradykinin is shown to be one of the main causative agents. The diagnosis is often delayed and traditional treatment usually ineffective. Complement C1 inhibitor concentrate and bradykinin receptor antagonists, normally used to treat patients with hereditary angioedema, have shown good results when used in patients with bradykinin-mediated angioedema. This review discusses the disease, prognosis and treatment options.

show abstract

“…Although the swelling can affect any part of the body, it has a predilection for areas with loose connective tissue, including the face (especially the lips, tongue and periorbital area), pharynx, larynx, abdomen, genitalia and extremities [11,12,13]. The swellings manifest as recurrent episodes of pronounced localized edema with ill-defined margins.…”

Section: Resultsmentioning

confidence: 99%

How Not to Be Misled by Disorders Mimicking Angioedema: A Review of Pseudoangioedema

Andersen¹,

Longhurst

Rasmussen

et al. 2016

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Angioedema is a vascular reaction involving the lower dermis, subcutis and/or submucosal tissue and causing a temporary localized swelling in any part of the body. For many health care professionals, the diagnosis presents an ongoing challenge; several disorders may manifest with subcutaneous or submucosal swelling and falsely be assumed to be angioedema. The clinicians at the emergency department and in the immunology/allergy clinics must be skilled at recognizing the features of angioedema and its differential diagnosis. Methods: The review is based on a literature search with specific indexing terms in PubMed, a review of bibliographies and the authors' clinical experience. Results: The most essential diseases that mimic angioedema, the so-called pseudoangioedemas, will each be discussed and illustrated by clinical photos, pointing out key features that help clarify the diagnoses and differentiate these from classic angioedema. Conclusions: A variety of dermatologic conditions can cause swelling that resembles angioedema, some with a potentially fatal outcome if misdiagnosed. Knowledge of pseudoangioedema is fundamental in the emergency setting when handling patients with edema and should be kept in mind when assessing an atypical angioedema case.

show abstract

Angioedema: A Review of 367 Episodes Presenting to Three Tertiary Care Hospitals

Abstract: The novel findings of this study are lower rates of airway intervention than reported previously and the fact that multiple affected sites were associated with admission and intubation or tracheostomy, particularly when the edema involved the larynx or hypopharynx.

Cited by 40 publications

References 19 publications

Life-Threatening Angioedema Induced by Angiotensin-Converting Enzyme Inhibitors: Characteristics and Risk Factors

Life-Threatening Angioedema Induced by Angiotensin-Converting Enzyme Inhibitors: Characteristics and Risk Factors

Angiotensin-converting Enzyme Inhibitor-induced Angioedema – A Dangerous New Epidemic

How Not to Be Misled by Disorders Mimicking Angioedema: A Review of Pseudoangioedema

Contact Info

Product

Resources

About